{"id":"https://openalex.org/W129193964","doi":null,"title":"TOXICIDADE GEN\u00c9TICA DAS ANTRACICLINAS: ASSOCIA\u00c7\u00c3O ENTRE ESTRUTURA QU\u00cdMICA E A\u00c7\u00c3O INIBIT\u00d3RIA SOBRE A TOPOISOMERASE II","display_name":"TOXICIDADE GEN\u00c9TICA DAS ANTRACICLINAS: ASSOCIA\u00c7\u00c3O ENTRE ESTRUTURA QU\u00cdMICA E A\u00c7\u00c3O INIBIT\u00d3RIA SOBRE A TOPOISOMERASE II","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W129193964","mag":"129193964"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3200293","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/2367","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/2367","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011744294","display_name":"Maur\u0131\u0301cio Lehmann","orcid":"https://orcid.org/0000-0001-5726-075X","observed_orcids":["https://orcid.org/0000-0001-5726-075X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maur\u0131\u0301cio Lehmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011744294"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.2856000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.9070000052452087},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibition","display_name":"topoisomerase II inhibition","score":0.9129999876022339},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.996999979019165},{"id":"https://openalex.org/keywords/idarubicin","display_name":"idarubicin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pirarubicin","display_name":"pirarubicin","score":0.949999988079071},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mitotic-recombination","display_name":"mitotic recombination","score":0.7260000109672546},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7459999918937683},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9739999771118164},{"id":"https://openalex.org/keywords/anticancer-drug-side-effects","display_name":"anticancer drug side effects","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.7018114328384399},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.6857984066009521},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5273759365081787},{"id":"https://openalex.org/C127764415","wikidata":"https://www.wikidata.org/wiki/Q6356161","display_name":"Mitotic crossover","level":4,"score":0.4919095039367676},{"id":"https://openalex.org/C2779117419","wikidata":"https://www.wikidata.org/wiki/Q1063862","display_name":"Idarubicin","level":4,"score":0.4815012216567993},{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.4574020504951477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44016045331954956},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4196189343929291},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4185147285461426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41693413257598877},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.4105079472064972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3714089095592499},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.35507291555404663},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.31404292583465576},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16701942682266235},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.1372782289981842},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.12876981496810913},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.09084281325340271},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08485224843025208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3200293","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/2367","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/2367","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/2367","pdf_url":"http://hdl.handle.net/10183/2367","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:lume.ufrgs.br:10183/2367","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/2367","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Tese"},{"id":"mag:129193964","doi":null,"is_oa":false,"landing_page_url":"https://www.lume.ufrgs.br/bitstream/handle/10183/2367/000368572.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3200293","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/2367","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W129193964.pdf","grobid_xml":"https://content.openalex.org/works/W129193964.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W75981909","https://openalex.org/W80581277","https://openalex.org/W438391561","https://openalex.org/W1491023198","https://openalex.org/W1575718683","https://openalex.org/W1587615774","https://openalex.org/W1605923556","https://openalex.org/W1825832082","https://openalex.org/W1869373838","https://openalex.org/W1964122915","https://openalex.org/W1964735445","https://openalex.org/W1965228400","https://openalex.org/W1966061343","https://openalex.org/W1966087521","https://openalex.org/W1966816322","https://openalex.org/W1972794196","https://openalex.org/W1973310837","https://openalex.org/W1979547768","https://openalex.org/W1979591487","https://openalex.org/W1981760975","https://openalex.org/W1983713447","https://openalex.org/W1983932760","https://openalex.org/W1985505903","https://openalex.org/W1986385313","https://openalex.org/W1992123017","https://openalex.org/W1994155152","https://openalex.org/W1998258082","https://openalex.org/W1999468683","https://openalex.org/W2006787449","https://openalex.org/W2010183849","https://openalex.org/W2011019741","https://openalex.org/W2011089596","https://openalex.org/W2011606700","https://openalex.org/W2019354174","https://openalex.org/W2021333879","https://openalex.org/W2023632989","https://openalex.org/W2024842128","https://openalex.org/W2025066357","https://openalex.org/W2027276169","https://openalex.org/W2029656668","https://openalex.org/W2035312348","https://openalex.org/W2041976716","https://openalex.org/W2042677337","https://openalex.org/W2046891625","https://openalex.org/W2050523583","https://openalex.org/W2050562499","https://openalex.org/W2051879930","https://openalex.org/W2054760667","https://openalex.org/W2059343681","https://openalex.org/W2061292851","https://openalex.org/W2068198382","https://openalex.org/W2069077740","https://openalex.org/W2069256784","https://openalex.org/W2069854470","https://openalex.org/W2071750125","https://openalex.org/W2079613111","https://openalex.org/W2081161641","https://openalex.org/W2082928509","https://openalex.org/W2083338918","https://openalex.org/W2087266655","https://openalex.org/W2090920178","https://openalex.org/W2093215149","https://openalex.org/W2094747148","https://openalex.org/W2097408234","https://openalex.org/W2100922079","https://openalex.org/W2103133372","https://openalex.org/W2105420066","https://openalex.org/W2112879605","https://openalex.org/W2113282769","https://openalex.org/W2126041423","https://openalex.org/W2130883309","https://openalex.org/W2133631919","https://openalex.org/W2137583404","https://openalex.org/W2139181266","https://openalex.org/W2149768758","https://openalex.org/W2158285323","https://openalex.org/W2158907381","https://openalex.org/W2187765434","https://openalex.org/W2203139323","https://openalex.org/W2223071669","https://openalex.org/W2327708631","https://openalex.org/W2339378175","https://openalex.org/W2465708327","https://openalex.org/W2484635393","https://openalex.org/W2518694165"],"related_works":["https://openalex.org/W1981662797","https://openalex.org/W2093215149","https://openalex.org/W2080136595","https://openalex.org/W2995206150","https://openalex.org/W7046748495","https://openalex.org/W2312672095","https://openalex.org/W2133631919","https://openalex.org/W2015775160","https://openalex.org/W3084161635","https://openalex.org/W3097718132"],"abstract_inverted_index":{"Considerando":[0],"n\u00e3o":[1,307,384,487],"apenas":[2],"a":[3,26,72,91,98,109,136,151,179,201,209,285,288,294,303,315,339,346,357,364,386,396,428,479,484],"import\u00e2ncia":[4],"das":[5,431],"antraciclinas":[6,31,117],"na":[7,334,401,437,448,451],"terap\u00eautica":[8],"do":[9,159,168,199,453],"c\u00e2ncer,":[10],"mas":[11,318],"tamb\u00e9m":[12,319],"os":[13,262],"efeitos":[14],"colaterais":[15],"associados":[16],"ao":[17,256,297,464],"uso":[18,33],"destas":[19,342,424,476],"drogas,":[20],"o":[21,59,145,182,203],"presente":[22],"estudo":[23,434],"procurou":[24],"avaliar":[25],"atividade":[27,312,360,485],"genot\u00f3xica":[28,212,341],"de":[29,47,61,75,82,170,175,192,215,238,246,273,325,332,336,403,439,458],"seis":[30],"em":[32,67,104,433,461],"cl\u00ednico":[34],"-":[35,88,139,143,249,276,284,406,442],"doxorrubicina":[36],"(DOX),":[37],"daunorrubicina":[38],"(DNR),":[39],"epirrubicina":[40],"(EPI),":[41],"idarrubicina":[42],"(IDA),":[43],"al\u00e9m":[44],"dos":[45,162],"an\u00e1logos":[46,263,377],"\u00faltima":[48],"gera\u00e7\u00e3o,":[49],"pirarrubicina":[50],"(THP)":[51],"e":[52,63,78,181,243,268,328,382],"aclarrubicina":[53],"(ACLA).":[54],"Para":[55],"tanto,":[56],"foi":[57,144,344],"empregado":[58],"Teste":[60],"Muta\u00e7\u00e3o":[62],"Recombina\u00e7\u00e3o":[64],"Som\u00e1tica":[65],"(SMART)":[66],"Drosophila":[68],"melanogaster,":[69],"que":[70,114,200,208,229,302,351,371,393,407,427],"permite":[71],"detec\u00e7\u00e3o":[73],"simult\u00e2nea":[74],"muta\u00e7\u00e3o":[76],"g\u00eanica":[77],"cromoss\u00f4mica,":[79],"assim":[80],"como":[81,184,197,271,323],"eventos":[83],"relacionados":[84,122],"com":[85,466],"recombina\u00e7\u00e3o":[86,128,137,404,440,480],"mit\u00f3tica":[87,138,405,481],"possibilitando":[89],"quantificar":[90],"contribui\u00e7\u00e3o":[92],"deste":[93,132],"\u00faltimo":[94],"par\u00e2metro":[95],"gen\u00e9tico":[96],"para":[97],"genotoxicidade":[99,304,429],"total":[100,430],"induzida":[101],"pelas":[102],"drogas":[103,186,343,432,477],"estudo.":[105],"Os":[106],"dados":[107],"obtidos":[108],"partir":[110],"desta":[111,213,291],"an\u00e1lise":[112],"demonstraram":[113],"todas":[115],"as":[116,185,250,279,372,467],"estudadas":[118],"induziram":[119],"acr\u00e9scimos":[120],"significativos,":[121],"tanto":[123,415,447],"\u00e0":[124,127,219,310,320,329,473],"muta\u00e7\u00e3o,":[125],"quanto":[126,419,450],"nas":[129],"c\u00e9lulas":[130],"som\u00e1ticas":[131],"inseto.":[133],"Al\u00e9m":[134],"disso,":[135],"entre":[140],"cromossomos":[141],"hom\u00f3logos":[142],"evento":[146,444],"respons\u00e1vel":[147],"por,":[148],"aproximadamente,":[149],"62":[150],"100%":[152],"da":[153,166,221,233,235,241,305],"toxicidade":[154],"gen\u00e9tica":[155],"observada.":[156],"A":[157,455],"compara\u00e7\u00e3o":[158],"potencial":[160],"genot\u00f3xico":[161],"diferentes":[163],"an\u00e1logos,":[164],"atrav\u00e9s":[165,240],"padroniza\u00e7\u00e3o":[167],"n\u00famero":[169],"danos":[171],"gen\u00e9ticos":[172],"por":[173],"unidade":[174],"tratamento":[176,465],"(mM),":[177],"caracterizou":[178],"ACLA":[180,286,306],"THP":[183,269],"mais":[187,195],"potentes":[188],"\u2013":[189,226,482],"sendo":[190],"cerca":[191],"20":[193],"vezes":[194],"efetivas,":[196],"genotoxinas,":[198],"DOX,":[202,264,378],"an\u00e1logo":[204],"menos":[205],"potente.":[206],"J\u00e1":[207],"principal":[210],"a\u00e7\u00e3o":[211,322,388,474],"fam\u00edlia":[214],"compostos":[216],"est\u00e1":[217,308,435],"relacionada":[218],"inibi\u00e7\u00e3o":[220],"topoisomerase":[222],"II":[223,275],"(topo":[224],"II)":[225],"uma":[227,358],"enzima":[228,283],"atua":[230],"no":[231,353,366,392,416,420],"relaxamento":[232],"supertor\u00e7\u00e3o":[234],"dupla":[236],"h\u00e9lice":[237],"DNA,":[239],"quebra":[242],"posterior":[244],"religa\u00e7\u00e3o":[245],"suas":[247,347],"fitas":[248],"diferen\u00e7as":[251],"observadas":[252],"podem":[253,408],"ser":[254,409,471,489],"atribu\u00eddas":[255,410],"mecanismo":[257],"envolvido":[258,446],"neste":[259],"bloqueio":[260],"Enquanto":[261],"DNR,":[265,379],"EPI,":[266,380],"IDA":[267,381],"atuam":[270],"venenos":[272],"topo":[274,316,326],"tornando":[277],"permanentes":[278],"quebras":[280],"induzidas":[281],"pela":[282],"inibe":[287],"fun\u00e7\u00e3o":[289],"catal\u00edtica":[290,313],"enzima,":[292],"impedindo":[293],"sua":[295,311,321,330,387],"liga\u00e7\u00e3o":[296],"DNA.":[298,337],"Cabe":[299,368],"ainda":[300,369],"ressaltar":[301,370],"restrita":[309],"sobre":[314,478],"II,":[317],"veneno":[324],"I":[327],"habilidade":[331],"intercalar-se":[333],"mol\u00e9cula":[335],"Quando":[338],"pot\u00eancia":[340],"associada":[345],"estruturas":[348],"qu\u00edmicas,":[349],"observou-se":[350],"substitui\u00e7\u00f5es":[352,413],"grupamento":[354,417],"amino-a\u00e7\u00facar":[355,418],"levaram":[356],"maior":[359],"t\u00f3xico-gen\u00e9tica,":[361],"quando":[362],"comparadas":[363],"modifica\u00e7\u00f5es":[365,373],"crom\u00f3foro.":[367,421],"estruturais,":[374],"presentes":[375,414],"nos":[376],"THP,":[383],"alteraram":[385],"recombinog\u00eanica.":[389],"No":[390],"entanto,":[391],"se":[394],"refere":[395],"ACLA,":[397],"observaram-se":[398],"decr\u00e9scimos":[399],"significativos":[400],"indu\u00e7\u00e3o":[402,438],"\u00e0s":[411],"m\u00faltiplas":[412],"O":[422],"conjunto":[423],"observa\u00e7\u00f5es":[425],"evidencia":[426],"centrada":[436],"hom\u00f3loga":[441],"um":[443],"predominantemente":[445],"inicia\u00e7\u00e3o,":[449],"progress\u00e3o":[452],"c\u00e2ncer.":[454],"alta":[456],"incid\u00eancia":[457],"tumores":[459],"secund\u00e1rios,":[460],"pacientes":[462],"submetidos":[463],"antraciclinas,":[468],"pode,":[469],"pois,":[470],"atribu\u00edda":[472],"preferencial":[475],"embora":[483],"mutag\u00eanica":[486],"possa":[488],"desconsiderada.":[490]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
