{"id":"https://openalex.org/W129174540","doi":null,"title":"Structure-function relationships in the four repeats of human interphotoreceptor retinoid-binding protein (IRBP).","display_name":"Structure-function relationships in the four repeats of human interphotoreceptor retinoid-binding protein (IRBP).","publication_year":1998,"publication_date":"1998-12-31","ids":{"openalex":"https://openalex.org/W129174540","mag":"129174540","pmid":"https://pubmed.ncbi.nlm.nih.gov/9873071"},"language":"en","primary_location":{"id":"pmid:9873071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9873071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112488034","display_name":"J M Nickerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210094864","display_name":"Emory Eye Center","ror":"https://ror.org/00hr6kp69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4210094864","https://openalex.org/I4210109911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Nickerson","raw_affiliation_strings":["Department of Ophthalmology, Emory Eye Center, Emory University, Atlanta GA 30322, USA. litjn@emory.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Emory Eye Center, Emory University, Atlanta GA 30322, USA. litjn@emory.edu","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210094864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109897092","display_name":"G R Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G R Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Z Y Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Y Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N Takizawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Takizawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102063298","display_name":"Jing-Sheng Si","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Si","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039917542","display_name":"Eleanore A. Gross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Gross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6782,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.62807666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":null,"first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.1738000065088272,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interphotoreceptor-retinoid-binding-protein","display_name":"interphotoreceptor retinoid-binding protein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retinoid-binding","display_name":"retinoid binding","score":0.8199999928474426},{"id":"https://openalex.org/keywords/fatty-acid-binding","display_name":"fatty acid binding","score":0.8069999814033508},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.625},{"id":"https://openalex.org/keywords/tryptophan-fluorescence-quenching","display_name":"tryptophan fluorescence quenching","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ligand-binding-site","display_name":"ligand binding sites","score":0.7929999828338623},{"id":"https://openalex.org/keywords/all-trans-retinol","display_name":"all-trans-retinol","score":0.7149999737739563},{"id":"https://openalex.org/keywords/9-cis-retinal","display_name":"9-cis-retinal","score":0.9520000219345093},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.8820000290870667},{"id":"https://openalex.org/keywords/parinaric-acid","display_name":"parinaric acid","score":0.75},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9079999923706055},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5202628374099731},{"id":"https://openalex.org/C97749175","wikidata":"https://www.wikidata.org/wiki/Q904727","display_name":"Retinol binding protein","level":4,"score":0.5078540444374084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.494396448135376},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.4560920298099518},{"id":"https://openalex.org/C2779573558","wikidata":"https://www.wikidata.org/wiki/Q424976","display_name":"Retinol","level":3,"score":0.4516529142856598},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4490545094013214},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4480774402618408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4322124719619751},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3877403736114502},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1668175458908081},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07600995898246765},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099214","descriptor_name":"Retinol-Binding Proteins, Interstitial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012177","descriptor_name":"Retinol-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012177","descriptor_name":"Retinol-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9873071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9873071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:129174540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9873071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5782007235","display_name":"FUNCTION OF THE RETINAL PROTEIN IRBP","funder_award_id":"R01EY010553","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000918204","display_name":"VIsion Science Training in Atlanta","funder_award_id":"T32EY007092","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W35241519","https://openalex.org/W812893516","https://openalex.org/W1452055526","https://openalex.org/W1549588670","https://openalex.org/W1975358267","https://openalex.org/W1976071843","https://openalex.org/W1996897401","https://openalex.org/W2005986251","https://openalex.org/W2006791133","https://openalex.org/W2007208973","https://openalex.org/W2010194803","https://openalex.org/W2018830698","https://openalex.org/W2048188877","https://openalex.org/W2054326088","https://openalex.org/W2054862233","https://openalex.org/W2059526131","https://openalex.org/W2061759292","https://openalex.org/W2064698003","https://openalex.org/W2066236105","https://openalex.org/W2081694019","https://openalex.org/W2088345052","https://openalex.org/W2090228630","https://openalex.org/W2125628590","https://openalex.org/W2129995310","https://openalex.org/W2146216956","https://openalex.org/W2155685033","https://openalex.org/W2169090256"],"related_works":["https://openalex.org/W2125628590","https://openalex.org/W181014179","https://openalex.org/W2138142183","https://openalex.org/W2007208973","https://openalex.org/W1575252597","https://openalex.org/W2064698003","https://openalex.org/W1523381267","https://openalex.org/W1482032908","https://openalex.org/W1489804071","https://openalex.org/W2022592544"],"abstract_inverted_index":{"PURPOSE:":[0],"Interphotoreceptor":[1],"retinoid-binding":[2],"protein":[3,59,104,122,165],"(IRBP)":[4],"binds":[5,267],"hydrophobic":[6],"ligands":[7],"in":[8,19,49,98,107,158,242,311,341],"the":[9,32,58,65,83,102,159,169,179,190,194,200,238,250,290,300,309,317,334],"interphotoreceptor":[10],"space.":[11],"Human":[12],"IRBP":[13,342],"consists":[14],"of":[15,31,121,146,193,202,240,263,299,337,346],"1230":[16],"amino":[17,22],"acids":[18],"four":[20,33,66,195,318],"300":[21],"acid":[23],"long":[24],"repeats.":[25,196],"We":[26],"asked:":[27],"1.":[28],"Whether":[29,42,53,64],"each":[30,43,80,232,274,294],"repeats":[34,67,95,256,310,319],"can":[35,45,56,68],"bind":[36,260],"retinoids":[37,269],"or":[38,254,280],"fatty":[39],"acids,":[40],"2.":[41],"repeat":[44,81,198,236,266,295],"prevent":[46],"retinol":[47,147,221,223,241],"degradation":[48,239],"aqueous":[50,243],"solutions,":[51],"3.":[52],"a":[54],"ligand":[55,116,175,277,313],"stabilize":[57],"from":[60,82,344],"thermal":[61],"denaturation,":[62],"4.":[63],"be":[69,321],"further":[70],"classified":[71,322],"into":[72,323],"two":[73,253,325],"groups.":[74,327],"Our":[75],"rationale":[76],"was":[77,105,135,149,156],"to":[78,163,173,259],"make":[79],"human":[84],"cDNA":[85],"and":[86,90,101,133,168,212,214,222,270],"then":[87],"examine":[88],"structural":[89],"functional":[91],"characteristics.":[92],"METHODS:":[93],"Individual":[94],"were":[96,113,140],"produced":[97],"E.":[99],"coli":[100],"whole":[103,301],"expressed":[106,235],"baculovirus.":[108],"Binding":[109,138],"properties":[110],"with":[111,249,284,333],"all-trans-retinol":[112],"characterized":[114],"by":[115,124,142,151,220],"fluorescence":[117,123,218,224],"enhancement.":[118],"The":[119,246],"quenching":[120,219],"retinol,":[125],"9-cis-retinal,":[126,204],"all-trans-retinoic":[127],"acid,":[128,132,208,210],"beta-ionine,":[129,213],"alpha-ionine,":[130],"trans-parinaric":[131,215],"DHA":[134],"also":[136],"examined.":[137],"curves":[139],"analyzed":[141],"nonlinear":[143],"regression.":[144],"Prevention":[145],"decomposition":[148],"measured":[150],"absorption":[152],"spectroscopy.":[153],"Circular":[154],"dichroism":[155],"examined":[157],"far":[160],"UV":[161,171],"range":[162,172],"study":[164,174],"secondary":[166],"structure":[167],"near":[170],"binding":[176,203,229,278,282,314,339,350],"effects":[177],"on":[178],"tryptophan":[180],"environment.":[181],"RESULTS:":[182],"Temperature":[183],"dependent":[184],"denaturation":[185],"suggests":[186],"that":[187,252,273,293],"EcR1":[188],"is":[189],"most":[191],"stable":[192],"Each":[197,234,265],"possesses":[199],"capability":[201],"all-trans-retinol,":[205],"all-trans":[206],"retinoic":[207],"docosahexaenoic":[209],"alpha-":[211],"acid.":[216],"Protein":[217],"enhancement":[225],"assays":[226],"yielded":[227],"similar":[228],"parameters":[230],"for":[231,286],"repeat.":[233],"prevents":[237],"solutions.":[244],"CONCLUSIONS:":[245],"data":[247,330],"contrast":[248],"idea":[251],"more":[255],"are":[257,305],"needed":[258],"one":[261,281],"molecule":[262],"ligand.":[264],"both":[268],"analogs,":[271],"suggesting":[272],"has":[275],"multiple":[276,338],"sites":[279,340],"site":[283],"affinity":[285],"different":[287],"ligands.":[288],"Together,":[289],"results":[291],"suggest":[292],"retains":[296],"all":[297],"functions":[298],"protein.":[302,351],"However,":[303],"there":[304],"distinguishing":[306],"characteristics":[307],"among":[308],"their":[312],"properties,":[315],"though":[316],"cannot":[320],"just":[324],"distinctive":[326],"Last,":[328],"these":[329],"fit":[331],"well":[332],"current":[335],"model":[336],"derived":[343],"quadruplication":[345],"an":[347],"ancestral":[348],"monomeric":[349]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
