{"id":"https://openalex.org/W129013342","doi":"https://doi.org/10.1158/1538-7445.am2019-506","title":"Abstract 506: Wnt/\u00e2-Catenin pathway inhibitor RXC004 enhances the immunity of pre-clinical models of cancer","display_name":"Abstract 506: Wnt/\u00e2-Catenin pathway inhibitor RXC004 enhances the immunity of pre-clinical models of cancer","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W129013342","doi":"https://doi.org/10.1158/1538-7445.am2019-506","mag":"129013342","pmid":"https://pubmed.ncbi.nlm.nih.gov/7691729","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421970"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-506","doi":"https://doi.org/10.1158/1538-7445.am2019-506","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-506","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108257450","display_name":"Caroline Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caroline Phillips","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082399428","display_name":"Inder Bhamra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Inder Bhamra","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063198530","display_name":"Catherine Eagle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Eagle","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045023434","display_name":"Alicia Edmenson Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alicia Edmenson Cook","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035244847","display_name":"Cliff Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cliff Jones","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003246050","display_name":"Simon A. Woodcock","orcid":"https://orcid.org/0000-0001-7363-757X","observed_orcids":["https://orcid.org/0000-0001-7363-757X"]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Woodcock","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162142"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"506","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.2964000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcupine-inhibitor","display_name":"porcupine inhibitor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9620000123977661},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9549999833106995},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.6779999732971191},{"id":"https://openalex.org/keywords/cxcl11","display_name":"CXCL11","score":0.6200000047683716},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cd103","display_name":"CD103","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.5929999947547913},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.3880000114440918},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6613590121269226},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6575809121131897},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6498581171035767},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6359065175056458},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6140173077583313},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5224577188491821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4980809688568115},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4731869697570801},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.42172810435295105},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41513341665267944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2892911434173584},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2662641108036041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19810223579406738},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.12497919797897339},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08920291066169739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019002","descriptor_name":"CD56 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1538-7445.am2019-506","doi":"https://doi.org/10.1158/1538-7445.am2019-506","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-506","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1421970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:7691729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7691729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1421970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1489850871","https://openalex.org/W1556867369","https://openalex.org/W1680276925","https://openalex.org/W1983320974","https://openalex.org/W2009885759","https://openalex.org/W2028178783","https://openalex.org/W2061229343","https://openalex.org/W2104066024","https://openalex.org/W2107411417","https://openalex.org/W2132363654"],"related_works":["https://openalex.org/W2885208058","https://openalex.org/W4290803731","https://openalex.org/W2956140870","https://openalex.org/W3178579248","https://openalex.org/W4308383995","https://openalex.org/W3202221618","https://openalex.org/W4362541190","https://openalex.org/W4393988384","https://openalex.org/W4281858602","https://openalex.org/W2890507523"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"RXC004,":[2],"a":[3,18,66,144,154,183,265,320,331],"potent":[4],"and":[5,20,49,78,87,124,131,166,189,283,311,401,412,415],"selective":[6],"inhibitor":[7,443],"of":[8,44,76,80,99,143,146,156,197,234,257,264,267,281,313,322,333,343,360,395,406,448,451,456],"the":[9,35,41,45,97,111,118,129,139,171,222,232,245,261,288,292,308,349,385,404,407,446,457],"Wnt/\u03b2-Catenin":[10],"pathway":[11,249,253,378,442],"regulator":[12],"porcupine,":[13],"is":[14,215,298,317],"being":[15],"investigated":[16],"in":[17,23,39,71,104,110,128,153,182,212,237,244,287,307,363],"safety":[19],"tolerability":[21],"study":[22],"cancer":[24,160,337,399,452],"patients":[25],"with":[26,225,346],"solid":[27],"tumors":[28,347,389],"(NCT03447470).":[29],"We":[30],"present":[31],"pre-clinical":[32,449],"data":[33],"confirming":[34],"potential":[36],"for":[37,84,460],"RXC004":[38,53,81,103,150,176,198,210,227,275,339,381,444],"modulating":[40],"immune":[42,100,125,268,350,386],"system":[43,351],"tumor":[46,92,112,180],"microenvironment.":[47],"Materials":[48],"Methods:":[50],"To":[51,94],"evaluate":[52],"as":[54,291],"an":[55,369],"immunomodulatory":[56],"anti-cancer":[57],"agent":[58],"we":[59],"took":[60],"two":[61],"complementary":[62],"approaches;":[63],"first":[64],"utilizing":[65],"syngeneic":[67,105,172],"B16F10":[68,173],"melanoma":[69,174],"model":[70,214],"C57BL/6":[72],"mice.":[73],"A":[74],"range":[75,145],"doses":[77],"schedules":[79],"were":[82,133,356],"tested":[83],"28":[85],"days":[86,201,204],"efficacy":[88],"was":[89,115,151],"measured":[90],"by":[91,102,135,149,303,380,390,409],"volume.":[93],"further":[95],"probe":[96],"mechanism":[98],"modulation":[101,142],"models,":[106],"global":[107],"gene":[108,122,167],"expression":[109,280,354],"microenvironment":[113],"(TME)":[114],"analyzed":[116,134],"using":[117,163,270],"Nanostring":[119,271],"IO":[120,272],"360":[121,273],"set,":[123],"cell":[126,161,294,324],"populations":[127],"blood":[130],"spleen":[132],"flow":[136,164],"cytometry.":[137],"In":[138,170,193,330],"second":[140],"approach,":[141],"immune-relevant":[147,396],"biomarkers":[148],"assessed":[152],"panel":[155,266,332],"Wnt":[157,248,252,334,377],"ligand-dependent":[158,335],"human":[159,336],"lines":[162],"cytometry":[165],"expression.":[168],"Results:":[169],"model,":[175],"treatment":[177,211,228,276,340,382],"significantly":[178],"reduced":[179,357],"volume":[181],"dose-dependent":[184],"manner":[185],"at":[186],"0.5,":[187],"1.5":[188],"5":[190,200],"mg/kg":[191],"QD.":[192],"addition,":[194],"5mg/kg":[195],"QD":[196],"scheduled":[199],"on,":[202],"2":[203],"off":[205],"also":[206],"gave":[207],"significant":[208],"efficacy.":[209],"this":[213],"known":[216],"to":[217,260,300,319,372],"decrease":[218],"myeloid-derived-suppressor-cells":[219],"(MDSCs)":[220],"within":[221],"TME.":[223,262],"Consistent":[224],"this,":[226],"(5mg/kg":[229,277],"QD)":[230,278],"increased":[231,279],"proportion":[233],"MDSCs":[235,239,411],"circulating":[236],"blood.":[238],"are":[240],"therefore":[241],"either":[242],"retained":[243],"TME":[246,310,408],"through":[247],"signaling,":[250],"or":[251],"signaling":[254,285],"promotes":[255],"chemotaxis":[256],"these":[258,314],"cells":[259,306,316],"Analysis":[263],"genes":[269],"demonstrated":[274],"chemokine":[282,414],"cytokine":[284,416],"components":[286],"TME,":[289],"such":[290,361],"T":[293,323],"chemoattractant":[295],"CXCL9.":[296],"CXCL9":[297],"reported":[299],"be":[301],"produced":[302],"CD103+ve":[304],"dendritic":[305,315],"mouse":[309],"absence":[312],"linked":[318],"lack":[321],"infiltrate":[325],"(Spranger":[326],"et":[327,419],"al.,":[328],"2017).":[329],"cells,":[338,400],"regulated":[341],"levels":[342,355,394],"markers":[344,362,397],"associated":[345],"evading":[348],"e.g.":[352],"MYC":[353],"significantly.":[358],"Modulation":[359],"paired":[364],"clinical":[365],"sample":[366],"may":[367],"indicate":[368],"immune-modulatory":[370],"response":[371,387],"RXC004.":[373],"Conclusion:":[374],"Taken":[375],"together,":[376],"suppression":[379],"can":[383],"enhance":[384],"against":[388],"1)":[391],"directly":[392],"regulating":[393],"on":[398],"2)":[402],"enhancing":[403],"immunity":[405,447],"decreasing":[410],"increasing":[413],"signaling.":[417],"Spranger":[418],"al":[420],"Cancer":[421,461,475],"Cell":[422],"2017":[423],"8":[424],"31(5):711-723":[425],"Citation":[426],"Format:":[427],"Caroline":[428],"Phillips,":[429],"Inder":[430],"Bhamra,":[431],"Catherine":[432],"Eagle,":[433],"Alicia":[434],"Edmenson":[435],"Cook,":[436],"Cliff":[437],"Jones,":[438],"Simon":[439],"Woodcock.":[440],"Wnt/\u00e2-Catenin":[441],"enhances":[445],"models":[450],"[abstract].":[453],"In:":[454],"Proceedings":[455],"American":[458],"Association":[459],"Research":[462],"Annual":[463],"Meeting":[464],"2019;":[465],"2019":[466],"Mar":[467],"29-Apr":[468],"3;":[469],"Atlanta,":[470],"GA.":[471],"Philadelphia":[472],"(PA):":[473],"AACR;":[474],"Res":[476],"2019;79(13":[477],"Suppl):Abstract":[478],"nr":[479],"506.":[480]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}