{"id":"https://openalex.org/W128895306","doi":null,"title":"Nuevos blancos moleculares en el c\u00e1ncer de pr\u00f3stata","display_name":"Nuevos blancos moleculares en el c\u00e1ncer de pr\u00f3stata","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W128895306","mag":"128895306"},"language":"es","primary_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5279_Moiola_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5279_Moiola","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/20.500.12110/tesis_n5279_Moiola","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089011260","display_name":"Cristian P. Moiola","orcid":"https://orcid.org/0000-0001-7218-0184","observed_orcids":["https://orcid.org/0000-0001-7218-0184"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Cristian P. Moiola","raw_affiliation_strings":["[University of Buenos Aires]"],"raw_orcid":"https://orcid.org/0000-0001-7218-0184","affiliations":[{"raw_affiliation_string":"[University of Buenos Aires]","institution_ids":["https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089011260"],"corresponding_institution_ids":["https://openalex.org/I24354313"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.4959999918937683},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.75},{"id":"https://openalex.org/keywords/ctip","display_name":"CtIP","score":0.6629999876022339},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.6859999895095825},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.6000000238418579},{"id":"https://openalex.org/keywords/ctbp1","display_name":"CtBP1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.5230000019073486},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.7400000095367432},{"id":"https://openalex.org/keywords/estrogen-biosynthesis","display_name":"estrogen synthesis","score":0.4490000009536743},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.4740000069141388},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.382999986410141},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.5600000023841858},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.4259999990463257},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.30300000309944153},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4244944751262665},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4069121479988098},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.40224626660346985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3406261205673218},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3373922109603882},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.23967108130455017},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14635834097862244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08927097916603088},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08551019430160522}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5279_Moiola_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5279_Moiola","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:americanae.aecid.es:3055304","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12110/tesis_n5279_Moiola","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:snrd:Tesis_5279_Moiola","doi":null,"is_oa":true,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&amp;c=tesis&amp;d=Tesis_5279_Moiola","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:tesis:tesis_n5279_Moiola","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5279_Moiola","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:oai:RDI UBA:aextesis:Tesis_5279_Moiola_oai","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&amp;c=tesis&amp;d=Tesis_5279_Moiola","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Tesis Doctoral"},{"id":"mag:128895306","doi":null,"is_oa":false,"landing_page_url":"https://bibliotecadigital.exactas.uba.ar/download/tesis/tesis_n5279_Moiola.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5279_Moiola_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5279_Moiola","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":141,"referenced_works":["https://openalex.org/W32782731","https://openalex.org/W148352488","https://openalex.org/W179057616","https://openalex.org/W221956105","https://openalex.org/W1207770767","https://openalex.org/W1419228847","https://openalex.org/W1487384429","https://openalex.org/W1487538033","https://openalex.org/W1492291341","https://openalex.org/W1495971837","https://openalex.org/W1515564094","https://openalex.org/W1548623780","https://openalex.org/W1665675901","https://openalex.org/W1752089945","https://openalex.org/W1768635289","https://openalex.org/W1801184284","https://openalex.org/W1821992417","https://openalex.org/W1963605606","https://openalex.org/W1971476329","https://openalex.org/W1972864222","https://openalex.org/W1975854213","https://openalex.org/W1977035912","https://openalex.org/W1980287224","https://openalex.org/W1983728536","https://openalex.org/W1985298987","https://openalex.org/W1985529128","https://openalex.org/W1989059483","https://openalex.org/W1990287298","https://openalex.org/W1990391716","https://openalex.org/W1992930985","https://openalex.org/W1993042966","https://openalex.org/W1995627894","https://openalex.org/W1997517088","https://openalex.org/W1998129814","https://openalex.org/W1999644099","https://openalex.org/W2001471842","https://openalex.org/W2002930907","https://openalex.org/W2009993892","https://openalex.org/W2012300945","https://openalex.org/W2012486985","https://openalex.org/W2016130776","https://openalex.org/W2016538215","https://openalex.org/W2017841963","https://openalex.org/W2026115642","https://openalex.org/W2028579977","https://openalex.org/W2028897202","https://openalex.org/W2030720512","https://openalex.org/W2030875435","https://openalex.org/W2032298890","https://openalex.org/W2034024919","https://openalex.org/W2034825007","https://openalex.org/W2034831440","https://openalex.org/W2037519090","https://openalex.org/W2038419615","https://openalex.org/W2039211343","https://openalex.org/W2043916245","https://openalex.org/W2044087374","https://openalex.org/W2045479279","https://openalex.org/W2046577989","https://openalex.org/W2047109055","https://openalex.org/W2048122656","https://openalex.org/W2051071724","https://openalex.org/W2053003311","https://openalex.org/W2053167710","https://openalex.org/W2054202198","https://openalex.org/W2055303628","https://openalex.org/W2055890925","https://openalex.org/W2057477877","https://openalex.org/W2057496292","https://openalex.org/W2057949133","https://openalex.org/W2059365987","https://openalex.org/W2059724367","https://openalex.org/W2059971436","https://openalex.org/W2061805003","https://openalex.org/W2067287544","https://openalex.org/W2067893818","https://openalex.org/W2068359474","https://openalex.org/W2072451938","https://openalex.org/W2076583198","https://openalex.org/W2077672512","https://openalex.org/W2078339225","https://openalex.org/W2082559623","https://openalex.org/W2084491471","https://openalex.org/W2085478590","https://openalex.org/W2099777151","https://openalex.org/W2102230986","https://openalex.org/W2103002602","https://openalex.org/W2103533058","https://openalex.org/W2105395542","https://openalex.org/W2106787323","https://openalex.org/W2106926141","https://openalex.org/W2107277218","https://openalex.org/W2109465247","https://openalex.org/W2109692972","https://openalex.org/W2111365962","https://openalex.org/W2112005084","https://openalex.org/W2112211663","https://openalex.org/W2112642897","https://openalex.org/W2113467627","https://openalex.org/W2113847379","https://openalex.org/W2117692326","https://openalex.org/W2118177072","https://openalex.org/W2118498634","https://openalex.org/W2120579697","https://openalex.org/W2121518362","https://openalex.org/W2121672275","https://openalex.org/W2122680090","https://openalex.org/W2125633317","https://openalex.org/W2125729266","https://openalex.org/W2125809738","https://openalex.org/W2127528448","https://openalex.org/W2128635872","https://openalex.org/W2129631700","https://openalex.org/W2133568239","https://openalex.org/W2134669147","https://openalex.org/W2134725999","https://openalex.org/W2138388674","https://openalex.org/W2138785710","https://openalex.org/W2141109950","https://openalex.org/W2141248073","https://openalex.org/W2141562227","https://openalex.org/W2145224695","https://openalex.org/W2148200419","https://openalex.org/W2153481815","https://openalex.org/W2155769914","https://openalex.org/W2159110813","https://openalex.org/W2159168998","https://openalex.org/W2159261007","https://openalex.org/W2160475700","https://openalex.org/W2160796704","https://openalex.org/W2164916497","https://openalex.org/W2166257800","https://openalex.org/W2168225429","https://openalex.org/W2169443052","https://openalex.org/W2170419735","https://openalex.org/W2171863181","https://openalex.org/W2314106020","https://openalex.org/W2328105863","https://openalex.org/W2403429472","https://openalex.org/W3142152021","https://openalex.org/W4243903519"],"related_works":["https://openalex.org/W141597425","https://openalex.org/W2316767106","https://openalex.org/W1505397567","https://openalex.org/W7168351767","https://openalex.org/W2163278610","https://openalex.org/W4414846820","https://openalex.org/W2078343553","https://openalex.org/W2955088895","https://openalex.org/W2619493098","https://openalex.org/W2103533058"],"abstract_inverted_index":{"El":[0],"c\u00e1ncer":[1,10],"de":[2,9,21,39,47,52,58,65,90,111,136,149,154,161,184,186,200,210,214,219,238,258,276,282,294,299,310,313,333,337,343,354,368,370,377,384,392,395,422,438,444],"pr\u00f3stata":[3,201],"(PCa)":[4],"es":[5,19],"el":[6,14,20,25,31,37,63,88,97,316,340,415,455],"segundo":[7,26],"tipo":[8],"m\u00e1s":[11],"frecuente":[12],"en":[13,27,62,67,87,151,163,172,190,196,207,271,303,381,399,432,454],"mundo.":[15],"En":[16,55,216,243,291,379],"la":[17,34,42,77,91,133,142,147,159,179,191,194,208,233,244,248,274,280,285,288,308,311,331,351,366,410,420,435],"Argentina,":[18],"mayor":[22],"incidencia":[23],"y":[24,41,105,113,124,227,287,409,440],"mortalidad.":[28],"La":[29],"edad,":[30],"origen":[32],"\u00e9tnico,":[33],"historia":[35],"familiar,":[36],"estilo":[38],"vida":[40],"obesidad":[43],"son":[44],"importantes":[45],"factores":[46,253],"riesgo":[48],"asociados":[49],"al":[50,72,109,360,375,401],"desarrollo":[51,73,416],"esta":[53],"patolog\u00eda.":[54],"este":[56,217,382],"trabajo":[57,218,383],"tesis":[59,220,385],"nos":[60],"centralizamos":[61],"rol":[64,451],"BRCA1":[66,82,123,150,162,228,239,259,398,439],"diferentes":[68],"v\u00edas":[69],"que":[70,96,139,171,223,251,266,279,307,357,362,372,406],"contribuyen":[71],"del":[74,83,236,256],"PCa.":[75,155,456],"Estudiamos":[76],"regulaci\u00f3n":[78,134,393,436],"transcripcional":[79,135,394,437],"mediada":[80],"por":[81,100,297,387,397],"gen":[84],"ATM,":[85],"clave":[86],"mantenimiento":[89],"estabilidad":[92],"gen\u00f3mica":[93],"celular.":[94,290],"Determinamos":[95],"complejo":[98],"formado":[99],"las":[101,164,173,197,224,334,355],"prote\u00ednas":[102,225],"BRCA1,":[103],"E2F1":[104],"CtIP,":[106],"se":[107,119,126,229,254,363],"asocian":[108],"promotor":[110,237,257],"ATM":[112,396],"activan":[114],"su":[115,129,241,261,441,450],"transcripci\u00f3n.":[116,130,242,262],"Asimismo,":[117,330],"cuando":[118,320],"induce":[120],"estr\u00e9s":[121,402],"genot\u00f3xico,":[122],"CtIP":[125],"liberan":[127],"reprimiendo":[128,240],"Adem\u00e1s,":[131],"estudiamos":[132],"BRCA1.":[137,187],"Encontramos":[138],"los":[140,182,321,407],"andr\u00f3genos,":[141,178],"principal":[143],"hormona":[144,157],"masculina,":[145],"regula":[146],"expresi\u00f3n":[148,185,275,312],"l\u00edneas":[152,264,335],"celulares":[153,265],"Esta":[156,188],"reprime":[158],"transcripci\u00f3n":[160],"c\u00e9lulas":[165,174,198,301,356],"LNCaP,":[166],"sensibles":[167],"a":[168,177,193,204,212,232,434],"andr\u00f3genos.":[169,215],"Mientras":[170],"PC3,":[175,247],"insensibles":[176],"testosterona":[180,195,249],"aumenta":[181,284],"niveles":[183],"diferencia":[189],"respuesta":[192,400],"tumorales":[199],"parece":[202],"responder":[203],"un":[205,292,390],"efecto":[206],"s\u00edntesis":[209],"estr\u00f3genos":[211],"partir":[213],"tambi\u00e9n":[221],"determinamos":[222,306,405],"CtBP1":[226,283,359],"encuentran":[230],"asociadas":[231],"regi\u00f3n":[234],"proximal":[235],"l\u00ednea":[245],"tumoral":[246,318,417,453],"provoca":[250],"estos":[252,427],"liberen":[255],"activando":[260],"Utilizando":[263],"sobre-expresan":[267,358],"o":[268],"tienen":[269],"disminuida":[270],"forma":[272],"estable":[273],"CtBP1,":[277],"encontramos":[278],"sobreexpresi\u00f3n":[281],"transformaci\u00f3n":[286],"viabilidad":[289],"modelo":[293],"xenotransplantes":[295],"generado":[296],"inoculaci\u00f3n":[298],"estas":[300],"estables":[302,336],"ratones":[304],"nude,":[305],"disminuci\u00f3n":[309],"CtBP1disminuy\u00f3":[314],"dr\u00e1sticamente":[315],"crecimiento":[317],"solo":[319],"animales":[322,344],"hab\u00edan":[323],"sido":[324],"alimentados":[325,345],"con":[326,339,346],"una":[327,347],"dieta":[328,348,411],"hipercal\u00f3rica.":[329],"incubaci\u00f3n":[332],"PC3":[338],"suero":[341],"proveniente":[342],"hipercal\u00f3rica":[349,412],"aumento":[350],"proliferaci\u00f3n":[352],"celular":[353],"igual":[361],"ven":[364],"favorecidos":[365],"activaci\u00f3n":[367],"procesos":[369],"EMT":[371],"podr\u00edan":[373],"conducir":[374],"establecimiento":[376],"met\u00e1stasis.":[378],"resumen,":[380],"describimos":[386],"primera":[388],"vez":[389],"mecanismo":[391],"genot\u00f3xico.":[403],"Adem\u00e1s":[404],"andr\u00f3genos":[408],"pueden":[413],"influenciar":[414],"prost\u00e1tico":[418],"alterando":[419],"v\u00eda":[421],"CtBP1/BRCA1.":[423],"Por":[424],"lo":[425],"tanto,":[426],"resultados":[428],"aportan":[429],"nuevas":[430],"evidencias":[431],"cuanto":[433],"funci\u00f3n":[442],"co-reguladora":[443],"otros":[445],"blancos":[446],"moleculares":[447],"fortaleciendo":[448],"as\u00ed":[449],"supresor":[452]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
