{"id":"https://openalex.org/W128755169","doi":null,"title":"Immune Modulation by the Mycobacterium tuberculosis mce1 operon","display_name":"Immune Modulation by the Mycobacterium tuberculosis mce1 operon","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W128755169","mag":"128755169"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt50h8t6xp","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/50h8t6xp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039697522","display_name":"Rebecca Anne Howsmon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rebecca Anne Howsmon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039697522"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bacterial-persistence","display_name":"bacterial persistence","score":0.8309999704360962},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.722000002861023},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.777999997138977},{"id":"https://openalex.org/keywords/mycolic-acids","display_name":"mycolic acids","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bacterial-envelope","display_name":"bacterial cell envelope","score":0.6269999742507935},{"id":"https://openalex.org/keywords/tlr2-signaling","display_name":"TLR2 signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hypervirulence","display_name":"hypervirulence","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.752429187297821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6827216744422913},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6560163497924805},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6521064043045044},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6052607297897339},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5334311723709106},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.526276171207428},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5028926730155945},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.49094250798225403},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.44428151845932007},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4195021092891693},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37657657265663147},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21873649954795837},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16636526584625244},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.154475599527359},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10468727350234985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10286390781402588},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt50h8t6xp","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/50h8t6xp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt50h8t6xp","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/50h8t6xp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Howsmon, Rebecca Anne. (2009). Immune Modulation by the Mycobacterium tuberculosis mce1 operon. UC Berkeley: Infectious Diseases &amp; Immunity. Retrieved from: http://www.escholarship.org/uc/item/50h8t6xp","raw_type":"dissertation"},{"id":"mag:128755169","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/50h8t6xp.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1490721606","https://openalex.org/W1525912444","https://openalex.org/W1538029215","https://openalex.org/W1548106543","https://openalex.org/W1570208240","https://openalex.org/W1683960100","https://openalex.org/W1792374007","https://openalex.org/W1842407033","https://openalex.org/W1848543179","https://openalex.org/W1905061145","https://openalex.org/W1945178855","https://openalex.org/W1954303926","https://openalex.org/W1966117438","https://openalex.org/W1969055840","https://openalex.org/W1975062192","https://openalex.org/W1976213712","https://openalex.org/W1976575734","https://openalex.org/W1980094540","https://openalex.org/W1982731967","https://openalex.org/W1999498760","https://openalex.org/W2007097682","https://openalex.org/W2019052483","https://openalex.org/W2023650245","https://openalex.org/W2028459461","https://openalex.org/W2029971722","https://openalex.org/W2031206118","https://openalex.org/W2033545363","https://openalex.org/W2035507375","https://openalex.org/W2042151443","https://openalex.org/W2047385405","https://openalex.org/W2052019440","https://openalex.org/W2055167382","https://openalex.org/W2061631323","https://openalex.org/W2064964564","https://openalex.org/W2065791817","https://openalex.org/W2065903108","https://openalex.org/W2067539471","https://openalex.org/W2071213243","https://openalex.org/W2082567385","https://openalex.org/W2082573007","https://openalex.org/W2083225421","https://openalex.org/W2090680389","https://openalex.org/W2094664036","https://openalex.org/W2097333857","https://openalex.org/W2097748813","https://openalex.org/W2098485516","https://openalex.org/W2099258581","https://openalex.org/W2099499236","https://openalex.org/W2107238732","https://openalex.org/W2110240848","https://openalex.org/W2114006967","https://openalex.org/W2121499583","https://openalex.org/W2122195274","https://openalex.org/W2122746019","https://openalex.org/W2126640823","https://openalex.org/W2127502319","https://openalex.org/W2128918222","https://openalex.org/W2129869755","https://openalex.org/W2130968927","https://openalex.org/W2131678844","https://openalex.org/W2133433794","https://openalex.org/W2134948698","https://openalex.org/W2137797951","https://openalex.org/W2139360890","https://openalex.org/W2145664616","https://openalex.org/W2146396140","https://openalex.org/W2148519348","https://openalex.org/W2150226488","https://openalex.org/W2151738661","https://openalex.org/W2153188511","https://openalex.org/W2154539914","https://openalex.org/W2154690748","https://openalex.org/W2157069655","https://openalex.org/W2159112596","https://openalex.org/W2161916137","https://openalex.org/W2168568296","https://openalex.org/W2170698511","https://openalex.org/W2171231066","https://openalex.org/W2171414034","https://openalex.org/W2176258339","https://openalex.org/W2268576130"],"related_works":["https://openalex.org/W2766843512","https://openalex.org/W2052019440","https://openalex.org/W2055167382","https://openalex.org/W3072922679","https://openalex.org/W1976213712","https://openalex.org/W2171912162","https://openalex.org/W2000372064","https://openalex.org/W2148519348","https://openalex.org/W2030272709","https://openalex.org/W3010418321"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1],"(M.tb),":[2],"the":[3,29,70,81,92,96,103,107,114,225,267,274,299,326,341],"causative":[4],"agent":[5],"of":[6,21,31,34,91,98,106,121,132,234,243,328,344],"tuberculosis,":[7],"is":[8,28,41,50,110,126,160],"a":[9,15,32,38,63,66,129,140,306],"highly":[10],"successful":[11],"pathogen":[12],"that":[13,40,79,87,158,191,217,246,273,322],"establishes":[14],"persistent":[16],"human":[17,22],"infection.":[18,133],"The":[19,231],"hallmark":[20],"host":[23,331],"response":[24,203],"to":[25,43,52,83,138,163,184,204,213,239,262,309],"M.tb":[26,49,122,257,329],"infection":[27,99,205],"formation":[30],"conglomeration":[33],"immune":[35,74,168,229,268,315,332],"cells":[36,153,183,211,333],"called":[37,69],"granuloma":[39],"thought":[42],"limit":[44],"bacterial":[45,300],"replication":[46],"and":[47,150,181,193,197,209,227,338],"spread.":[48],"able":[51],"persist":[53],"within":[54,76],"this":[55,77,159,171,345],"harsh":[56],"environment.":[57],"Research":[58],"from":[59,277],"our":[60],"laboratory":[61],"demonstrates":[62],"role":[64,222],"for":[65,113,220],"13-gene":[67],"cluster":[68],"mce1":[71,93,117],"operon":[72,94,118],"in":[73,89,102,128,202,223,250,304,325],"modulation":[75],"environment":[78],"allows":[80],"bacilli":[82],"persist.":[84],"We":[85,189,253],"hypothesize":[86],"fluctuations":[88],"expression":[90],"during":[95],"course":[97],"are":[100,136,218,247],"involved":[101],"stable":[104],"maintenance":[105],"granuloma,":[108],"which":[109],"also":[111,254],"protective":[112],"mycobacteria.":[115],"A":[116],"mutant":[119],"strain":[120],"(":[123],"dmce1":[124,156,207,235,278],")":[125],"hypervirulent":[127],"mouse":[130,176],"model":[131],"Infected":[134],"mice":[135],"unable":[137],"mount":[139],"proper":[141],"granulomatous":[142],"response.":[143,169,269],"In":[144,170],"vitro":[145],"studies":[146],"with":[147,155,206,330],"RAW":[148],"macrophages":[149,180],"A549":[151],"epithelial":[152],"infected":[154],"demonstrate":[157],"likely":[161],"due":[162],"an":[164,241],"aberrant":[165],"early":[166,323],"innate":[167,226,314],"dissertation":[172],"we":[173],"used":[174],"primary":[175],"bone":[177],"marrow":[178],"derived":[179],"dendritic":[182,194,210,291],"further":[185],"corroborate":[186],"these":[187,295],"findings.":[188],"found":[190],"macrophage":[192,289],"cell":[195,232,292,301],"cytokine":[196],"chemokine":[198],"production":[199],"was":[200,236],"impaired":[201],",":[208],"failed":[212],"upregulate":[214],"costimulatory":[215],"molecules":[216],"essential":[219],"their":[221],"linking":[224],"adaptive":[228],"responses.":[230],"envelope":[233],"shown":[237],"previously":[238],"contain":[240],"accumulation":[242],"mycolic":[244],"acids":[245],"not":[248,280],"present":[249],"wild-type":[251],"M.tb.":[252],"investigated":[255],"whether":[256],"alters":[258],"its":[259],"lipid":[260],"profile":[261],"directly":[263,287],"or":[264,290,349],"indirectly":[265],"modulate":[266],"Our":[270],"data":[271],"show":[272,321],"accumulated":[275],"lipids":[276,296],"do":[279,285],"block":[281],"TLR2":[282],"signaling,":[283],"nor":[284],"they":[286],"inhibit":[288],"activation.":[293],"Instead,":[294],"may":[297],"alter":[298],"wall":[302],"architecture":[303],"such":[305],"way":[307],"as":[308],"induce":[310],"other,":[311],"yet":[312],"uncharacterized":[313],"signaling":[316],"pathway.":[317],"These":[318],"observations,":[319],"nevertheless,":[320],"events":[324],"interaction":[327,346],"have":[334],"dramatic":[335],"consequences":[336],"later,":[337],"ultimately":[339],"determine":[340],"clinical":[342],"fate":[343],"\u2014":[347],"persistence":[348],"active":[350],"disease.":[351]},"counts_by_year":[],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2016-06-24T00:00:00"}
