{"id":"https://openalex.org/W128613416","doi":null,"title":"Biomarkers of oxidative stress and their application for assessment of individual radiosensitivity.","display_name":"Biomarkers of oxidative stress and their application for assessment of individual radiosensitivity.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W128613416","mag":"128613416"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-749","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-749","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-749","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013840032","display_name":"Siamak Haghdoost","orcid":"https://orcid.org/0000-0002-2867-4774","observed_orcids":["https://orcid.org/0000-0002-2867-4774"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Siamak Haghdoost","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2867-4774","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5013840032"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6230000257492065},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/8-oxo-7-8-dihydro-2-deoxyguanosine","display_name":"8-oxo-7,8-dihydro-2'-deoxyguanosine","score":0.9549999833106995},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5550000071525574},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.5450000166893005},{"id":"https://openalex.org/keywords/nucleotide-pools","display_name":"nucleotide pools","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mth1","display_name":"MTH1","score":0.6779999732971191},{"id":"https://openalex.org/keywords/urine","display_name":"urine","score":0.4440000057220459},{"id":"https://openalex.org/keywords/breast-cancer-radiotherapy","display_name":"breast cancer radiotherapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/normal-tissue-reactions","display_name":"normal tissue response","score":0.7039999961853027},{"id":"https://openalex.org/keywords/dialysis-patients","display_name":"dialysis patients","score":0.7020000219345093},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/oxidative-stress-biomarkers","display_name":"oxidative stress biomarkers","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.6167478561401367},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5629988312721252},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5625196695327759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.468336820602417},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43306291103363037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4317217767238617},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3672100305557251},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3477376103401184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30305278301239014}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:su-749","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-749","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:128613416","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/get/diva2:198402/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-749","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-749","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W65030405","https://openalex.org/W91705684","https://openalex.org/W104942731","https://openalex.org/W1538513556","https://openalex.org/W1544553682","https://openalex.org/W1547489990","https://openalex.org/W1602460334","https://openalex.org/W1602773114","https://openalex.org/W1603824866","https://openalex.org/W1647075334","https://openalex.org/W1928195896","https://openalex.org/W1965121800","https://openalex.org/W1965884923","https://openalex.org/W1969107888","https://openalex.org/W1972725000","https://openalex.org/W1976679977","https://openalex.org/W1977913875","https://openalex.org/W1978548397","https://openalex.org/W1978948673","https://openalex.org/W1987286530","https://openalex.org/W1988122871","https://openalex.org/W1993066203","https://openalex.org/W1995446858","https://openalex.org/W1996044070","https://openalex.org/W1996978408","https://openalex.org/W1997471619","https://openalex.org/W1998649277","https://openalex.org/W2001565772","https://openalex.org/W2003711294","https://openalex.org/W2003937841","https://openalex.org/W2004352006","https://openalex.org/W2010597170","https://openalex.org/W2012071848","https://openalex.org/W2017541181","https://openalex.org/W2019362208","https://openalex.org/W2019369653","https://openalex.org/W2019963243","https://openalex.org/W2024809491","https://openalex.org/W2025926121","https://openalex.org/W2028648537","https://openalex.org/W2030578737","https://openalex.org/W2031068201","https://openalex.org/W2034141196","https://openalex.org/W2037211079","https://openalex.org/W2041206657","https://openalex.org/W2042041984","https://openalex.org/W2043945205","https://openalex.org/W2044770423","https://openalex.org/W2050568705","https://openalex.org/W2054277474","https://openalex.org/W2055869166","https://openalex.org/W2056106885","https://openalex.org/W2065032892","https://openalex.org/W2065159766","https://openalex.org/W2065774340","https://openalex.org/W2071351849","https://openalex.org/W2074354979","https://openalex.org/W2078677832","https://openalex.org/W2080392363","https://openalex.org/W2080758954","https://openalex.org/W2084588612","https://openalex.org/W2084914439","https://openalex.org/W2085050051","https://openalex.org/W2086605133","https://openalex.org/W2087249338","https://openalex.org/W2088814535","https://openalex.org/W2092770418","https://openalex.org/W2093041725","https://openalex.org/W2095938938","https://openalex.org/W2105364421","https://openalex.org/W2106880428","https://openalex.org/W2108170463","https://openalex.org/W2109543726","https://openalex.org/W2121454542","https://openalex.org/W2122621484","https://openalex.org/W2123362394","https://openalex.org/W2127863767","https://openalex.org/W2131209256","https://openalex.org/W2133519577","https://openalex.org/W2134440723","https://openalex.org/W2136943372","https://openalex.org/W2138012803","https://openalex.org/W2144339916","https://openalex.org/W2148076163","https://openalex.org/W2154442296","https://openalex.org/W2159564294","https://openalex.org/W2164437042","https://openalex.org/W2168989880","https://openalex.org/W2169819365","https://openalex.org/W2171977217","https://openalex.org/W2175768595","https://openalex.org/W2176384617","https://openalex.org/W2248574755","https://openalex.org/W2309845957","https://openalex.org/W2325945535","https://openalex.org/W2398064360","https://openalex.org/W2418939889","https://openalex.org/W3217307355","https://openalex.org/W4301863469"],"related_works":["https://openalex.org/W1997471619","https://openalex.org/W2100251939","https://openalex.org/W1999067101","https://openalex.org/W1995446858","https://openalex.org/W3172949256","https://openalex.org/W6981400418","https://openalex.org/W2910645606","https://openalex.org/W2804015492","https://openalex.org/W3091866959","https://openalex.org/W4302067459"],"abstract_inverted_index":{"Radiotherapy":[0],"is":[1,24,131,182,204,401],"one":[2,183],"of":[3,11,14,19,31,38,46,57,80,91,97,110,118,125,145,154,164,179,184,188,190,199,265,312,326,357,363,407,415,431],"the":[4,36,47,55,72,98,106,115,140,152,185,196,200,229,250,298,313,317,332,339,418],"most":[5,73],"common":[6],"therapeutic":[7],"methods":[8],"for":[9,171,245,297,429],"treatment":[10,32],"many":[12,17],"types":[13],"cancer.":[15],"Despite":[16],"decades":[18],"development":[20],"and":[21,33,63,160,195,218,234,285,292,300,390],"experience":[22],"there":[23,130],"much":[25],"to":[26,34,61,150,208,228,316,352,383,424,434],"improve,":[27],"both":[28],"in":[29,54,71,105,157,255,261,267,272,306,331,345,368,404,417],"efficacy":[30],"decrease":[35],"incidences":[37],"adverse":[39],"healthy":[40],"tissue":[41,59],"reactions.":[42],"Around":[43],"20":[44],"%":[45],"radiotherapy":[48,92,296],"patients":[49,75,81,275,303,374],"show":[50],"a":[51,123,176,360,376,402,422,426],"broad":[52],"range":[53],"severity":[56],"normal":[58],"reactions":[60,70,248],"radiotherapy,":[62],"dose":[64,100],"limits":[65],"are":[66,224],"governed":[67],"by":[68,412],"severe":[69],"radiosensitive":[74,299,302],"(<":[76],"5":[77],"%).":[78],"Identification":[79],"with":[82,101,193,212,249,386,421],"low,":[83],"moderate":[84],"or":[85],"high":[86,283],"clinical":[87,141,172,427],"radiosensitivity":[88,159],"before":[89],"commencing":[90],"would":[93],"allow":[94],"individual":[95,158,432],"adaptation":[96],"maximum":[99],"an":[102],"overall":[103],"increase":[104,288,294],"cure":[107],"rate.":[108],"Characterization":[109],"factors":[111],"that":[112,136,398],"may":[113],"modify":[114],"biological":[116],"effects":[117],"ionizing":[119,191],"radiation":[120,165,192,262],"has":[121,148],"been":[122,149,270],"subject":[124],"intense":[126],"research":[127],"efforts.":[128],"Still,":[129],"no":[132,286],"assay":[133],"currently":[134],"available":[135],"can":[137,240],"reliably":[138],"predict":[139],"radiosensitivity.":[142],"The":[143,221,321,355],"aim":[144],"this":[146,353],"work":[147],"investigate":[151],"role":[153],"oxidative":[155,180,329,364,388,408,413],"stress":[156,330,365],"evaluate":[161],"novel":[162],"markers":[163,244],"response,":[166],"which":[167],"could":[168],"be":[169,241,384],"adapted":[170],"use.":[173],"8-Oxo-7,8-dihydro-2'-deoxyguanosine":[174],"(8-oxo-dG),":[175],"general":[177],"marker":[178,362],"stress,":[181,409],"major":[186,279,310],"products":[187],"interaction":[189],"DNA":[194],"nucleotide":[197,314,340,419],"pool":[198,315,341,420],"cell.":[201],"As":[202],"8-oxo-dG":[203,266,319,358,400],"highly":[205],"mutagenic":[206],"due":[207],"incorrect":[209],"base":[210],"pairing":[211],"deoxyadenosine,":[213],"various":[214],"repair":[215],"mechanisms":[216],"recognize":[217],"remove":[219],"8-oxo-dG.":[220,392],"repaired":[222],"lesions":[223],"released":[225],"from":[226],"cells":[227],"extracellular":[230,318,391,399],"milieu":[231],"(serum,":[232],"urine":[233,268],"cell":[235],"culture":[236],"medium)":[237],"where":[238],"they":[239],"detected":[242],"as":[243,258,260,359],"free":[246],"radical":[247],"nucleic":[251],"acids.":[252],"Significant":[253],"variations":[254],"background":[256,284,291],"levels":[257,264],"well":[259],"induced":[263],"have":[269],"demonstrated":[271,367],"breast":[273],"cancer":[274],"(paper":[276],"1).":[277],"Two":[278],"patterns":[280],"were":[281],"observed:":[282],"therapy-related":[287],"vs.":[289],"low":[290],"significant":[293],"during":[295],"non":[301],"respectively.":[304],"Studies":[305,371],"paper":[307,346,369],"2":[308],"indicated":[309],"contribution":[311],"levels.":[320],"results":[322,396],"also":[323],"implicated":[324],"induction":[325],"prolonged":[327],"endogenous":[328],"irradiated":[333],"cells.":[334],"RNA":[335],"\u201cknock-down\u201d":[336],"experiments":[337],"on":[338,372],"sanitization":[342],"enzyme":[343],"hMTH1":[344],"3":[347],"lend":[348],"further":[349],"experimental":[350],"evidence":[351],"assumption.":[354],"applicability":[356],"diagnostic":[361],"was":[366],"4.":[370],"dialysis":[373],"revealed":[375],"good":[377],"correlation":[378],"between":[379],"inflammatory":[380],"responses":[381,433],"(known":[382],"associated":[385],"persistent":[387],"stress)":[389],"In":[393],"summary,":[394],"our":[395],"confirm":[397],"sensitive":[403],"vivo":[405],"biomarker":[406],"primarily":[410],"formed":[411],"damage":[414],"dGTP":[416],"potential":[423],"become":[425],"tool":[428],"prediction":[430],"radiotherapy.":[435]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
