{"id":"https://openalex.org/W12860643","doi":"https://doi.org/10.1016/b978-0-12-571145-6.50016-9","title":"Regulation of Steroid Hydroxylase Gene Expression Is Multifactorial in Nature","display_name":"Regulation of Steroid Hydroxylase Gene Expression Is Multifactorial in Nature","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W12860643","doi":"https://doi.org/10.1016/b978-0-12-571145-6.50016-9","mag":"12860643","pmid":"https://pubmed.ncbi.nlm.nih.gov/2554434"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-571145-6.50016-9","doi":"https://doi.org/10.1016/b978-0-12-571145-6.50016-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-571145-6.50016-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 1988 Laurentian Hormone Conference","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4253564093","display_name":"Proceedings of the 1988 Laurentian Hormone Conference"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112342237","display_name":"Michael R. Waterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL R. WATERMAN","raw_affiliation_strings":["Departments of Biochemistry and Obstetrics and Gynecology, and the Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Obstetrics and Gynecology, and the Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109171376","display_name":"Evan R. Simpson","orcid":"https://orcid.org/0009-0004-6507-5326","observed_orcids":["https://orcid.org/0009-0004-6507-5326","https://orcid.org/0000-0002-4448-214X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EVAN R. SIMPSON","raw_affiliation_strings":["Departments of Biochemistry and Obstetrics and Gynecology, and the Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Obstetrics and Gynecology, and the Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":31.5566,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.9954955,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"45","issue":null,"first_page":"533","last_page":"566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steroid-hydroxylase","display_name":"steroid hydroxylase","score":0.906000018119812},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7950000166893005},{"id":"https://openalex.org/keywords/camp-independent-signaling","display_name":"cAMP-independent signaling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/developmental-regulation","display_name":"developmental regulation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/trans-acting-factors","display_name":"trans-acting factors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.9599999785423279},{"id":"https://openalex.org/keywords/steroidogenic-enzymes","display_name":"steroidogenic enzymes","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6209045052528381},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5747814774513245},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5218693017959595},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.47876134514808655},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.4677334725856781},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.43275269865989685},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36961880326271057},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32855111360549927},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18073248863220215},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17031386494636536}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/b978-0-12-571145-6.50016-9","doi":"https://doi.org/10.1016/b978-0-12-571145-6.50016-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-571145-6.50016-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 1988 Laurentian Hormone Conference","raw_type":"book-chapter"},{"id":"pmid:2554434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2554434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent progress in hormone research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G195914860","display_name":null,"funder_award_id":"DK-28350","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4531744191","display_name":null,"funder_award_id":"HD 13234","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G872767678","display_name":null,"funder_award_id":"HD-11149","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W5440973","https://openalex.org/W262256019","https://openalex.org/W303025491","https://openalex.org/W790202683","https://openalex.org/W1483337972","https://openalex.org/W1484750832","https://openalex.org/W1488427520","https://openalex.org/W1492098985","https://openalex.org/W1493181842","https://openalex.org/W1496688565","https://openalex.org/W1498234043","https://openalex.org/W1503945025","https://openalex.org/W1534713573","https://openalex.org/W1539141878","https://openalex.org/W1555680215","https://openalex.org/W1564556915","https://openalex.org/W1566630225","https://openalex.org/W1567608321","https://openalex.org/W1568019658","https://openalex.org/W1569327355","https://openalex.org/W1570978364","https://openalex.org/W1578941266","https://openalex.org/W1580057573","https://openalex.org/W1583576764","https://openalex.org/W1589163769","https://openalex.org/W1593254516","https://openalex.org/W1593287105","https://openalex.org/W1599803012","https://openalex.org/W1604557203","https://openalex.org/W1646275491","https://openalex.org/W1677444111","https://openalex.org/W1691201861","https://openalex.org/W1825170318","https://openalex.org/W1846043808","https://openalex.org/W1939710844","https://openalex.org/W1948557576","https://openalex.org/W1959543560","https://openalex.org/W1963545612","https://openalex.org/W1964331183","https://openalex.org/W1966127363","https://openalex.org/W1967037817","https://openalex.org/W1968479204","https://openalex.org/W1968596816","https://openalex.org/W1969730155","https://openalex.org/W1971539282","https://openalex.org/W1973216325","https://openalex.org/W1976281420","https://openalex.org/W1980952181","https://openalex.org/W1983586249","https://openalex.org/W1987416248","https://openalex.org/W1988701791","https://openalex.org/W1989231624","https://openalex.org/W1991136318","https://openalex.org/W1993887819","https://openalex.org/W1994593868","https://openalex.org/W1995098290","https://openalex.org/W1996133815","https://openalex.org/W1999341812","https://openalex.org/W1999587115","https://openalex.org/W2001384169","https://openalex.org/W2003065309","https://openalex.org/W2003258422","https://openalex.org/W2005992354","https://openalex.org/W2014301837","https://openalex.org/W2014319693","https://openalex.org/W2015197852","https://openalex.org/W2017825169","https://openalex.org/W2019043837","https://openalex.org/W2019527863","https://openalex.org/W2023552284","https://openalex.org/W2027432588","https://openalex.org/W2028449924","https://openalex.org/W2029228301","https://openalex.org/W2029779827","https://openalex.org/W2030345447","https://openalex.org/W2031410274","https://openalex.org/W2033342330","https://openalex.org/W2033345598","https://openalex.org/W2034697766","https://openalex.org/W2035615072","https://openalex.org/W2036216281","https://openalex.org/W2038949527","https://openalex.org/W2046016516","https://openalex.org/W2046438084","https://openalex.org/W2046559874","https://openalex.org/W2047928106","https://openalex.org/W2048325444","https://openalex.org/W2054894398","https://openalex.org/W2055839498","https://openalex.org/W2058984449","https://openalex.org/W2060019603","https://openalex.org/W2060180669","https://openalex.org/W2065168154","https://openalex.org/W2065340102","https://openalex.org/W2067494864","https://openalex.org/W2067962651","https://openalex.org/W2068490929","https://openalex.org/W2070697949","https://openalex.org/W2071743090","https://openalex.org/W2072898572","https://openalex.org/W2077063665","https://openalex.org/W2077483112","https://openalex.org/W2078288264","https://openalex.org/W2079593839","https://openalex.org/W2081687544","https://openalex.org/W2085602910","https://openalex.org/W2086745298","https://openalex.org/W2088590108","https://openalex.org/W2089436991","https://openalex.org/W2092182853","https://openalex.org/W2093373508","https://openalex.org/W2094175335","https://openalex.org/W2094412914","https://openalex.org/W2094446335","https://openalex.org/W2099670101","https://openalex.org/W2102122649","https://openalex.org/W2121612834","https://openalex.org/W2125701765","https://openalex.org/W2151473497","https://openalex.org/W2152929682","https://openalex.org/W2153393925","https://openalex.org/W2154664381"],"related_works":["https://openalex.org/W1545133530","https://openalex.org/W1964222493","https://openalex.org/W2066146323","https://openalex.org/W1773661406","https://openalex.org/W1872541645","https://openalex.org/W1992035496","https://openalex.org/W2076849178","https://openalex.org/W7097118508","https://openalex.org/W2102122649","https://openalex.org/W2402735724"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
