{"id":"https://openalex.org/W128199948","doi":null,"title":"Post-transcriptional Regulation of Mammalian Gene Expression in Non-coding Region of Target RNA","display_name":"Post-transcriptional Regulation of Mammalian Gene Expression in Non-coding Region of Target RNA","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W128199948","mag":"128199948"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1333","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/299","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100674238","display_name":"Jing Lin","orcid":"https://orcid.org/0000-0002-9025-1721","observed_orcids":["https://orcid.org/0000-0002-9025-1721"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jing Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9025-1721","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100674238"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.16439999639987946,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.05090000107884407,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tusc2","display_name":"TUSC2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/upstream-open-reading-frames","display_name":"upstream open reading frames","score":0.7609999775886536},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.9490000009536743},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9750000238418579},{"id":"https://openalex.org/keywords/let-7-microrna","display_name":"let-7 microRNA","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hmga2","display_name":"HMGA2","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/mirna-induced-silencing-complex","display_name":"miRNA-induced silencing complex","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ribosome-scanning","display_name":"ribosome scanning","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6830000281333923},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.75}],"concepts":[{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6155099868774414},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5899556279182434},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5811338424682617},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5014557838439941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4895575940608978},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48944178223609924},{"id":"https://openalex.org/C178809742","wikidata":"https://www.wikidata.org/wiki/Q3455913","display_name":"Post-transcriptional regulation","level":4,"score":0.46282893419265747},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4181886613368988},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4033788740634918},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1333","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/299","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:128199948","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1333&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W56705923","https://openalex.org/W144423133","https://openalex.org/W151786846","https://openalex.org/W1531414226","https://openalex.org/W1566430503","https://openalex.org/W1609687385","https://openalex.org/W1648301895","https://openalex.org/W1884035761","https://openalex.org/W1920303762","https://openalex.org/W1964813963","https://openalex.org/W1967543716","https://openalex.org/W1974481647","https://openalex.org/W1976840413","https://openalex.org/W1978337436","https://openalex.org/W1978536034","https://openalex.org/W1981667551","https://openalex.org/W1988163167","https://openalex.org/W1992605446","https://openalex.org/W1992695694","https://openalex.org/W1992941735","https://openalex.org/W1997767982","https://openalex.org/W2002995168","https://openalex.org/W2003230246","https://openalex.org/W2004271888","https://openalex.org/W2006694659","https://openalex.org/W2007463943","https://openalex.org/W2007515109","https://openalex.org/W2009229545","https://openalex.org/W2010299451","https://openalex.org/W2010461414","https://openalex.org/W2010542690","https://openalex.org/W2013868665","https://openalex.org/W2014946489","https://openalex.org/W2017426710","https://openalex.org/W2018233879","https://openalex.org/W2018859562","https://openalex.org/W2019387053","https://openalex.org/W2020367693","https://openalex.org/W2024799598","https://openalex.org/W2024869761","https://openalex.org/W2025453886","https://openalex.org/W2030120875","https://openalex.org/W2030621748","https://openalex.org/W2031752845","https://openalex.org/W2032964111","https://openalex.org/W2036755237","https://openalex.org/W2039034666","https://openalex.org/W2040250676","https://openalex.org/W2040851473","https://openalex.org/W2041306541","https://openalex.org/W2042673698","https://openalex.org/W2044758458","https://openalex.org/W2045175368","https://openalex.org/W2048910343","https://openalex.org/W2049868101","https://openalex.org/W2050066317","https://openalex.org/W2053227651","https://openalex.org/W2056795440","https://openalex.org/W2058982772","https://openalex.org/W2059073003","https://openalex.org/W2061452886","https://openalex.org/W2066718232","https://openalex.org/W2067915426","https://openalex.org/W2071925802","https://openalex.org/W2074370703","https://openalex.org/W2076984671","https://openalex.org/W2079372953","https://openalex.org/W2081339873","https://openalex.org/W2082997857","https://openalex.org/W2084245305","https://openalex.org/W2091204895","https://openalex.org/W2094418791","https://openalex.org/W2095125813","https://openalex.org/W2097265352","https://openalex.org/W2100990361","https://openalex.org/W2101543035","https://openalex.org/W2102304447","https://openalex.org/W2105679485","https://openalex.org/W2113869362","https://openalex.org/W2117962018","https://openalex.org/W2119086628","https://openalex.org/W2120141187","https://openalex.org/W2120366160","https://openalex.org/W2120597581","https://openalex.org/W2130979840","https://openalex.org/W2131459517","https://openalex.org/W2133968430","https://openalex.org/W2134340554","https://openalex.org/W2135314242","https://openalex.org/W2136400757","https://openalex.org/W2138664009","https://openalex.org/W2144372599","https://openalex.org/W2147114301","https://openalex.org/W2147495091","https://openalex.org/W2148008586","https://openalex.org/W2149146453","https://openalex.org/W2149385948","https://openalex.org/W2151922790","https://openalex.org/W2152267176","https://openalex.org/W2152571861","https://openalex.org/W2153586332","https://openalex.org/W2155649150","https://openalex.org/W2158010566","https://openalex.org/W2158861987","https://openalex.org/W2158878989","https://openalex.org/W2159807040","https://openalex.org/W2159907278","https://openalex.org/W2161149887","https://openalex.org/W2161222316","https://openalex.org/W2161283857","https://openalex.org/W2162674813","https://openalex.org/W2163199119","https://openalex.org/W2163731437","https://openalex.org/W2166179294","https://openalex.org/W2167557255","https://openalex.org/W2170034446","https://openalex.org/W2171833185","https://openalex.org/W2612812586","https://openalex.org/W4298284232","https://openalex.org/W7073834223"],"related_works":["https://openalex.org/W2007373191","https://openalex.org/W2048067268","https://openalex.org/W2334124544","https://openalex.org/W2046324232","https://openalex.org/W2318946107","https://openalex.org/W2505548330","https://openalex.org/W2735154959","https://openalex.org/W2023947760","https://openalex.org/W2904255427","https://openalex.org/W2144548050"],"abstract_inverted_index":{"Tumor":[0],"Suppressor":[1],"Candidate":[2],"2":[3],"(TUSC2)":[4],"is":[5],"a":[6,46,159,298],"novel":[7],"tumor":[8],"suppressor":[9],"gene":[10,83],"located":[11],"in":[12,27,45,61,84,100,173,210,238,264,273],"the":[13,71,74,81,85,101,108,117,120,149,164,200,219,232,235,239,303],"human":[14],"chromosome":[15],"3p21.3":[16],"region.":[17],"TUSC2":[18,40,55,82,88,104,112,141],"mRNA":[19,157,170,188,191,306,312,315],"transcripts":[20],"could":[21,42,105],"be":[22,43],"detected":[23,44],"on":[24,203],"Northern":[25],"blots":[26],"both":[28,286],"normal":[29],"lung":[30,33,49,63],"and":[31,58,76,139,143,190,234,252,272,288,317],"some":[32],"cancer":[34,50,64],"cell":[35,51],"lines,":[36],"but":[37],"no":[38,182],"endogenous":[39],"protein":[41,56,89,113],"majority":[47],"of":[48,73,80,87,103,111,119,166,168,184,305],"lines.":[52],"Mechanisms":[53],"regulating":[54],"expression":[57],"its":[59],"inactivation":[60],"primary":[62],"cells":[65,175],"are":[66,229],"largely":[67],"unknown.":[68],"We":[69,91],"investigated":[70],"role":[72],"5\u2019-":[75],"3\u2019-untranslated":[77],"regions":[78],"(UTRs)":[79],"regulation":[86,167,304],"expression.":[90],"found":[92],"that":[93,199,307],"two":[94],"small":[95],"upstream":[96],"open-reading":[97],"frames":[98],"(uORFs)":[99],"5\u2019UTR":[102],"markedly":[106],"inhibit":[107],"translational":[109],"initiation":[110,122],"by":[114,171,194,207,231],"interfering":[115],"with":[116,282],"\u201cscanning\u201d":[118],"ribosome":[121],"complexes.":[123],"Site-specific":[124],"stem-loop":[125],"array":[126],"reverse":[127],"transcription-polymerase":[128],"chain":[129],"reaction":[130],"(SLA-RT-PCR)":[131],"verified":[132],"several":[133],"micoRNAs":[134],"(miRNAs)":[135],"targeted":[136],"at":[137,249],"3\u2019UTR":[138],"directed":[140,215],"cleavage":[142,216,316],"degradation.":[144,257],"In":[145],"addition,":[146],"we":[147,197],"used":[148],"established":[150],"let-7-targeted":[151],"high":[152],"mobility":[153],"group":[154],"A2":[155],"(Hmga2)":[156],"as":[158],"model":[160],"system":[161],"to":[162,280,297],"study":[163],"mechanism":[165,301],"target":[169,223,311,314],"miRNAs":[172],"mammalian":[174,208,299],"under":[176],"physiological":[177],"conditions.":[178],"There":[179],"have":[180,225],"been":[181],"evidence":[183],"direct":[185],"link":[186],"between":[187],"downregulation":[189],"cleavages":[192,202],"mediated":[193],"miRNAs.":[195],"Here":[196],"showed":[198],"endonucleolytic":[201,287],"mRNAs":[204],"were":[205,246],"initiated":[206],"miRNA":[209,308],"seed":[211],"pairing":[212],"style.":[213],"Let-7":[214],"activities":[217],"among":[218],"eight":[220],"predicted":[221],"potential":[222],"sites":[224],"varied":[226],"efficiency,":[227],"which":[228],"influenced":[230],"positional":[233],"structural":[236],"contexts":[237],"UTR.":[240],"The":[241],"5\u2019":[242],"cleaved":[243],"RNA":[244,258,266,275],"fragments":[245,267],"mostly":[247],"oligouridylated":[248],"their":[250],"3\u2019-termini":[251],"accumulated":[253],"for":[254,268,302],"delayed":[255,269],"5\u2019\u20133\u2019":[256,281],"fragment":[259],"oligouridylation":[260],"played":[261],"important":[262],"roles":[263],"marking":[265],"bulk":[270],"degradation":[271,276],"converting":[274],"mode":[277],"from":[278,285],"3\u2019\u20135\u2019":[279],"cooperative":[283],"efforts":[284],"non-catalytic":[289],"miRNA-induced":[290],"silencing":[291],"complex":[292],"(miRISC).":[293],"Our":[294],"findings":[295],"point":[296],"miRNA-mediated":[300],"can":[309],"decrease":[310],"through":[313],"uridine":[318],"addition":[319]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
