{"id":"https://openalex.org/W128154692","doi":"https://doi.org/10.1007/978-1-62703-541-5_16","title":"Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy","display_name":"Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W128154692","doi":"https://doi.org/10.1007/978-1-62703-541-5_16","mag":"128154692","pmid":"https://pubmed.ncbi.nlm.nih.gov/23913153"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-62703-541-5_16","doi":"https://doi.org/10.1007/978-1-62703-541-5_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-541-5_16","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2502579088","display_name":"Antibody-Drug Conjugates"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100378070","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0002-2571-913X","observed_orcids":["https://orcid.org/0000-0002-2571-913X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yan Chen","raw_affiliation_strings":["Protein Analytical Chemistry, Genentech Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Analytical Chemistry, Genentech Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100378070"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":null,"apc_paid":null,"fwci":5.8654,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.96193984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"1045","issue":null,"first_page":"267","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-to-antibody-ratio","display_name":"drug-to-antibody ratio","score":0.996999979019165},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9909999966621399},{"id":"https://openalex.org/keywords/uv-vis-spectroscopy","display_name":"UV-Vis spectroscopy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/protein-concentration-determination","display_name":"protein concentration determination","score":0.7749999761581421},{"id":"https://openalex.org/keywords/extinction-coefficient","display_name":"extinction coefficient","score":0.8970000147819519},{"id":"https://openalex.org/keywords/drug-conjugation","display_name":"drug conjugation","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.7522138357162476},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7125606536865234},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6546899080276489},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.610816240310669},{"id":"https://openalex.org/C66075629","wikidata":"https://www.wikidata.org/wiki/Q898426","display_name":"Ultraviolet visible spectroscopy","level":2,"score":0.6013027429580688},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.5306274890899658},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.49220243096351624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44820713996887207},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3708893656730652},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.1982397735118866},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19149434566497803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18034493923187256},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17311322689056396},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12215191125869751},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08064672350883484},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05213114619255066},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.04742240905761719},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-62703-541-5_16","doi":"https://doi.org/10.1007/978-1-62703-541-5_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-541-5_16","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:23913153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23913153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1530999669","https://openalex.org/W1537235822","https://openalex.org/W1577233933","https://openalex.org/W1964905214","https://openalex.org/W2005333680","https://openalex.org/W2043306817","https://openalex.org/W2051296150","https://openalex.org/W2055713782","https://openalex.org/W2073176225","https://openalex.org/W2088005853","https://openalex.org/W2104017463","https://openalex.org/W2111436441","https://openalex.org/W2120103427","https://openalex.org/W2132235209","https://openalex.org/W2154302491","https://openalex.org/W2171368669","https://openalex.org/W2242788071"],"related_works":["https://openalex.org/W4389341848","https://openalex.org/W2461520869","https://openalex.org/W4409920664","https://openalex.org/W3203338545","https://openalex.org/W4366317312","https://openalex.org/W2395596906","https://openalex.org/W7163700722","https://openalex.org/W2897004776","https://openalex.org/W4386454453","https://openalex.org/W2752837807"],"abstract_inverted_index":{"UV/Vis":[0],"spectroscopy":[1],"is":[2],"a":[3],"simple":[4],"and":[5,38,45],"convenient":[6],"method":[7],"to":[8,23],"determine":[9],"protein":[10],"concentrations":[11],"as":[12,14],"well":[13],"the":[15,24,32,36,39,43,46,48],"average":[16,49],"number":[17],"of":[18,35,42],"drugs":[19],"that":[20],"are":[21],"conjugated":[22],"antibody":[25,44],"in":[26],"an":[27],"antibody-drug":[28],"conjugate":[29],"(ADC).":[30],"Using":[31],"measured":[33],"absorbances":[34],"ADC":[37],"extinction":[40],"coefficients":[41],"drug,":[47],"drug-to-antibody":[50],"ratio":[51],"(DAR)":[52],"can":[53],"be":[54],"determined.":[55]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
