{"id":"https://openalex.org/W12808980","doi":null,"title":"Acetyl-L-carnitine in the treatment of mildly demented elderly patients.","display_name":"Acetyl-L-carnitine in the treatment of mildly demented elderly patients.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W12808980","mag":"12808980","pmid":"https://pubmed.ncbi.nlm.nih.gov/2201659"},"language":"en","primary_location":{"id":"pmid:2201659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2201659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology research","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112781830","display_name":"M Passeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Passeri","raw_affiliation_strings":["Department of Internal Medicine, University of Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005444334","display_name":"Domenico Cucinotta","orcid":"https://orcid.org/0000-0002-8159-5709","observed_orcids":["https://orcid.org/0000-0002-8159-5709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Cucinotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002757743","display_name":"P Bonati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Bonati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075303977","display_name":"Maurizio Iannuccelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Iannuccelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019846852","display_name":"Lucilla Parnetti","orcid":"https://orcid.org/0000-0001-5722-3967","observed_orcids":["https://orcid.org/0000-0001-5722-3967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Parnetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011919079","display_name":"Umberto Senin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Senin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3793,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.59789429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"1-2","first_page":"75","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.19210000336170197,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.16850000619888306,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyl-l-carnitine","display_name":"acetyl-L-carnitine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.8709999918937683},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8009999990463257},{"id":"https://openalex.org/keywords/senile-dementia","display_name":"senile dementia","score":0.843999981880188},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7749999761581421},{"id":"https://openalex.org/keywords/acetylcholine-deficiency","display_name":"acetylcholine deficiency","score":0.906000018119812},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.746999979019165},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.7239999771118164},{"id":"https://openalex.org/keywords/verbal-fluency","display_name":"verbal fluency","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7972571849822998},{"id":"https://openalex.org/C2993097608","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Senile dementia","level":4,"score":0.6675814390182495},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.6468108296394348},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.635979413986206},{"id":"https://openalex.org/C97530452","wikidata":"https://www.wikidata.org/wiki/Q7920939","display_name":"Verbal fluency test","level":4,"score":0.6298021674156189},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.6247264742851257},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5764751434326172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.457755446434021},{"id":"https://openalex.org/C3017583242","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Placebo group","level":4,"score":0.45246267318725586},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4407826066017151},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43494969606399536},{"id":"https://openalex.org/C2776509080","wikidata":"https://www.wikidata.org/wiki/Q309406","display_name":"Apathy","level":3,"score":0.4327981173992157},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.27249449491500854},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.23584648966789246},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2044389843940735},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09137395024299622},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.0764041543006897},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000108","descriptor_name":"Acetylcarnitine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2201659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2201659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology research","raw_type":"Clinical Trial"},{"id":"mag:12808980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2201659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2398750331","https://openalex.org/W2410814611","https://openalex.org/W1975693728","https://openalex.org/W13871583","https://openalex.org/W2146165120","https://openalex.org/W7005501225","https://openalex.org/W1589659473","https://openalex.org/W2416535338","https://openalex.org/W93550323","https://openalex.org/W1988721068"],"abstract_inverted_index":{"It":[0,10,95],"has":[1,6,17],"been":[2,18],"hypothesized":[3],"that":[4,15,100],"acetyl-L-carnitine":[5,102,136],"a":[7,79],"cholinomimetic":[8],"action.":[9],"is":[11],"for":[12,69],"this":[13],"reason":[14],"it":[16],"used":[19],"in":[20,109,113,117,123,137],"the":[21,30,35,73,85,101,110,114,118,124,132,138],"therapy":[22,64],"of":[23,42,45,61,84,135,140],"Alzheimer's":[24],"type":[25],"senile":[26],"dementia":[27],"impairment.":[28,58],"In":[29],"present":[31],"controlled":[32],"double-blind":[33],"study":[34],"authors":[36],"followed":[37],"two":[38],"randomized":[39],"homogeneous":[40],"groups":[41],"both":[43],"sexes":[44],"30":[46],"patients":[47,62,104,142],"each,":[48],"aged":[49],"over":[50],"65":[51],"years":[52],"and":[53,122],"suffering":[54],"from":[55],"mild":[56],"mental":[57,144],"One":[59],"group":[60,75],"underwent":[63],"with":[65,78,143],"acetyl-L-carnitine,":[66],"2":[67],"g/day":[68],"three":[70],"months,":[71],"while":[72],"other":[74],"was":[76,87,96],"treated":[77,103],"placebo.":[80],"The":[81],"statistical":[82],"evaluation":[83],"results":[86,130],"carried-out":[88],"using":[89],"non-parametric":[90],"methods":[91],"(Friedman-Nemenyi":[92],"two-way":[93],"ANOVA).":[94],"possible":[97],"to":[98,151],"affirm":[99],"showed":[105],"statistically":[106],"significant":[107],"improvement":[108],"behavioural":[111],"scales,":[112],"memory":[115],"tests,":[116],"attention":[119],"barrage":[120],"test":[121],"Verbal":[125],"Fluency":[126],"test.":[127],"These":[128],"satisfactory":[129],"confirm":[131],"therapeutic":[133],"importance":[134],"treatment":[139],"elderly":[141],"impairment,":[145],"which":[146],"could":[147],"be":[148],"related":[149],"principally":[150],"acetylcholine":[152],"defects.":[153]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}