{"id":"https://openalex.org/W127947786","doi":null,"title":"Role of cytoprotectants and nitric oxide inhibition in nonsteroidal anti-inflammatory drug-induced gastroduodenal injury in the rat.","display_name":"Role of cytoprotectants and nitric oxide inhibition in nonsteroidal anti-inflammatory drug-induced gastroduodenal injury in the rat.","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W127947786","mag":"127947786","pmid":"https://pubmed.ncbi.nlm.nih.gov/10857004"},"language":"en","primary_location":{"id":"pmid:10857004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10857004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103377973","display_name":"Patricia V. Turner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P V Turner","raw_affiliation_strings":["Parke-Davis Research Institute, Mississauga, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parke-Davis Research Institute, Mississauga, Ontario, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108596830","display_name":"Mudher Albassam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Albassam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110238506","display_name":"Dean H. Percy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D H Percy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109957805","display_name":"Len E Lillie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L E Lillie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088931112","display_name":"Grace E. Macallum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G E Macallum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.361,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63955852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"50","issue":"2","first_page":"140","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9350000023841858},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.7080000042915344},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7170000076293945},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.9789999723434448},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9160000085830688},{"id":"https://openalex.org/keywords/misoprostol","display_name":"misoprostol","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sucralfate","display_name":"sucralfate","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ranitidine","display_name":"ranitidine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cysteamine","display_name":"cysteamine","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2776609658","wikidata":"https://www.wikidata.org/wiki/Q617563","display_name":"Cysteamine","level":2,"score":0.8583613038063049},{"id":"https://openalex.org/C2776246392","wikidata":"https://www.wikidata.org/wiki/Q420394","display_name":"Sucralfate","level":2,"score":0.8039189577102661},{"id":"https://openalex.org/C2777445857","wikidata":"https://www.wikidata.org/wiki/Q423037","display_name":"Ranitidine","level":2,"score":0.7774685621261597},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6912297010421753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6250593662261963},{"id":"https://openalex.org/C2779199973","wikidata":"https://www.wikidata.org/wiki/Q416025","display_name":"Misoprostol","level":4,"score":0.615415632724762},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.57349693775177},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46506932377815247},{"id":"https://openalex.org/C2776809568","wikidata":"https://www.wikidata.org/wiki/Q134955","display_name":"Duodenum","level":2,"score":0.4638267755508423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45957231521606445},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4331511855125427},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.42143601179122925},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000863","descriptor_name":"Antacids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003543","descriptor_name":"Cysteamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011899","descriptor_name":"Ranitidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013392","descriptor_name":"Sucralfate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016595","descriptor_name":"Misoprostol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10857004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10857004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Comparative Study"},{"id":"mag:127947786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10857004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052777784","https://openalex.org/W4242021827","https://openalex.org/W2007933562","https://openalex.org/W1995834850","https://openalex.org/W2010875023","https://openalex.org/W1966073662","https://openalex.org/W2027539046","https://openalex.org/W2429325231","https://openalex.org/W2356045151","https://openalex.org/W97953175"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Nonsteroidal":[3],"anti-inflammatory":[4],"drugs":[5],"(NSAIDs)":[6],"induce":[7],"gastroduodenal":[8,37,176],"injury":[9,121,177,218,238],"and":[10,21,153,173,181,192,195,225],"ulceration.":[11],"The":[12,28,167],"pathogenesis":[13],"is":[14,212],"uncertain,":[15],"although":[16],"reductions":[17],"in":[18,47,214,219,239],"cytoprotective":[19,32,223],"prostaglandins":[20,224],"nitric":[22],"oxide":[23],"(NO)":[24],"have":[25],"been":[26],"proposed.":[27],"effects":[29],"of":[30,36,62,67,97,102,107,113,126,129,136,142,161,175,209,222],"several":[31],"agents":[33],"on":[34,200],"inhibition":[35],"ulcerogenesis":[38],"induced":[39,123,178,187,203],"by":[40,124,179,188,204],"CI-987,":[41],"a":[42,60,88],"novel":[43],"NSAID,":[44],"were":[45,54,92,146,197],"evaluated":[46],"Wistar":[48,52],"rats.":[49,220,240],"METHODS:":[50],"Male":[51],"rats":[53,91],"given":[55,190],"CI-987":[56,180,189],"orally":[57],"(p.o.)":[58],"at":[59],"dosage":[61],"300":[63,140],"or":[64,70,78,110,139,163],"450":[65,127],"mg/kg":[66],"body":[68],"weight":[69],"subcutaneously":[71],"(s.c.)":[72],"(3":[73],"x":[74,83,133],"50":[75,134],"mg/kg),":[76],"alone":[77],"with":[79,94],"misoprostol":[80],"pretreatment":[81],"(2":[82],"1":[84],"mg/kg,":[85],"p.o.).":[86],"In":[87],"second":[89],"experiment,":[90],"pre-treated":[93],"2":[95],"ml":[96],"gelusil":[98],"p.o.,":[99,104,131],"500":[100],"mg":[101,106,112,128,135,141],"sucralfate/kg,":[103],"100":[105],"ranitidine/kg":[108],"s.c.,":[109,138,191],"200":[111],"N":[114],"omega-nitro-L-arginine":[115],"methyl":[116],"ester":[117],"(L-NAME)/kg,":[118],"s.c..":[119],"Duodenal":[120],"was":[122,157],"administration":[125],"CI-987/kg,":[130,137],"3":[132],"cysteamine/kg,":[143],"s.c.":[144],"Animals":[145],"euthanized":[147],"within":[148],"24":[149],"to":[150,231],"48":[151],"hours,":[152],"the":[154,171],"gastrointestinal":[155],"tract":[156],"examined":[158],"for":[159],"evidence":[160],"gross":[162],"microscopic":[164],"change.":[165],"RESULTS:":[166],"L-NAME":[168],"significantly":[169],"reduced":[170],"incidence":[172],"severity":[174],"cysteamine.":[182],"Prostaglandin":[183],"ameliorated":[184],"duodenal":[185,201,217,237],"lesions":[186,202],"Gelusil,":[193],"ranitidine,":[194],"sucralfate":[196],"without":[198],"effect":[199],"NSAID.":[205],"CONCLUSIONS:":[206],"Preemptive":[207],"blockade":[208],"NO":[210],"synthase":[211],"important":[213],"preventing":[215],"NSAID-induced":[216,236],"Inhibition":[221],"enhanced":[226],"acid-induced":[227],"damage":[228],"are":[229],"unlikely":[230],"be":[232],"primary":[233],"mechanisms":[234],"underlying":[235]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}