{"id":"https://openalex.org/W1278700533","doi":null,"title":"Expression and Clinical Significance of PTEN and Bcl-2 in Nasopharyngeal Carcinoma Tissue","display_name":"Expression and Clinical Significance of PTEN and Bcl-2 in Nasopharyngeal Carcinoma Tissue","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1278700533","mag":"1278700533"},"language":"en","primary_location":{"id":"mag:1278700533","doi":null,"is_oa":true,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20093126496","pdf_url":null,"source":{"id":"https://openalex.org/S2764486304","display_name":"Zhongliu fangzhi yanjiu","issn_l":"1000-8578","issn":["1000-8578"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323253487","host_organization_name":"Hubei Cancer Hospital","host_organization_lineage":["https://openalex.org/P4323253487"],"host_organization_lineage_names":["Hubei Cancer Hospital"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongliu fangzhi yanjiu","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cabdirect.org/cabdirect/abstract/20093126496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080421647","display_name":"Yangyun Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyun Liu","raw_affiliation_strings":["Department of Otolaryngology,The Second Affiliated Hospital of Hu\u2032nan Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology,The Second Affiliated Hospital of Hu\u2032nan Normal University","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023641786","display_name":"Liu Geng-xun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu Geng-xun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103288789","display_name":"Zhengxian Li","orcid":"https://orcid.org/0009-0008-7728-9232","observed_orcids":["https://orcid.org/0009-0008-7728-9232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengxian Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100932464","display_name":"Zhengliang Sun","orcid":"https://orcid.org/0009-0004-0847-6131","observed_orcids":["https://orcid.org/0009-0004-0847-6131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengliang Sun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-0847-6131","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102047239","display_name":"Zhou GuangHua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhou GuangHua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Wen Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Jiang","raw_affiliation_strings":["Department of Otolaryngology,The Second Affiliated Hospital of Hu\u2032nan Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology,The Second Affiliated Hospital of Hu\u2032nan Normal University","institution_ids":["https://openalex.org/I173759888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"CNY","value_usd":72},"apc_paid":{"value":500,"currency":"CNY","value_usd":72},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06435125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"2","first_page":"115","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-invasion-and-metastasis","display_name":"tumor invasion and metastasis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/t-stage","display_name":"T stage","score":0.7329999804496765},{"id":"https://openalex.org/keywords/nasopharyngeal-epithelium","display_name":"nasopharyngeal epithelium","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5429999828338623},{"id":"https://openalex.org/keywords/apoptosis-regulation","display_name":"apoptosis regulation","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.961601734161377},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.8247161507606506},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6902421116828918},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6073459386825562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5615919232368469},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5499446392059326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5230706334114075},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5042833089828491},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.49292778968811035},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.42768919467926025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3007766604423523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27280521392822266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18422412872314453},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.16391542553901672},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.060509175062179565},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1278700533","doi":null,"is_oa":true,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20093126496","pdf_url":null,"source":{"id":"https://openalex.org/S2764486304","display_name":"Zhongliu fangzhi yanjiu","issn_l":"1000-8578","issn":["1000-8578"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323253487","host_organization_name":"Hubei Cancer Hospital","host_organization_lineage":["https://openalex.org/P4323253487"],"host_organization_lineage_names":["Hubei Cancer Hospital"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongliu fangzhi yanjiu","raw_type":null}],"best_oa_location":{"id":"mag:1278700533","doi":null,"is_oa":true,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20093126496","pdf_url":null,"source":{"id":"https://openalex.org/S2764486304","display_name":"Zhongliu fangzhi yanjiu","issn_l":"1000-8578","issn":["1000-8578"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323253487","host_organization_name":"Hubei Cancer Hospital","host_organization_lineage":["https://openalex.org/P4323253487"],"host_organization_lineage_names":["Hubei Cancer Hospital"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongliu fangzhi yanjiu","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2015141503","https://openalex.org/W2384768625","https://openalex.org/W2387172012","https://openalex.org/W2364084297","https://openalex.org/W2377299774","https://openalex.org/W2376495071","https://openalex.org/W2357190205","https://openalex.org/W2724659887","https://openalex.org/W2363423024","https://openalex.org/W2387377983"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,72,91,108],"expression":[4,32,68,115,137,142],"and":[5,9,16,27,35,45,80,93,100,128,140,160],"interrelationship":[6],"of":[7,29,33,78,138,143,162],"phospharase":[8],"tensill":[10],"homolog":[11],"deleted":[12],"on":[13],"chromosome":[14],"ten(PTEN)":[15],"B-cell":[17],"lymphoma/leukemia-2(Bcl-2)":[18],"in":[19,25,39,86,97,131,147,157],"NPC.To":[20],"evaluate":[21],"their":[22,151],"clinical":[23],"implications":[24],"carcinogenesis,development,invasion":[26],"metastasis":[28,161],"NPC.Methods":[30],"The":[31],"PTEN":[34,61,79,99,127,139],"Bcl-2":[36,66,81,101,114,129,144],"was":[37,62,69,116,123],"examined":[38],"50":[40],"poorly":[41],"differentiated":[42],"NPC":[43,87,92,132,148],"samples":[44,60],"15":[46,56],"normal":[47,57,94],"nasopharyngeal":[48,58,95],"epithelium":[49,59,96],"tissues":[50],"using":[51],"immunohistochemical":[52],"staining(SP":[53],"method).Results":[54],"In":[55],"highly":[63],"expressed":[64],"but":[65,112],"protein":[67,82],"limited":[70],"to":[71,107,155],"basal":[73],"cell":[74],"layer.The":[75],"positive":[76],"rates":[77],"expressions":[83,102,130],"were":[84,103,145],"22%(11/50),82%(41/50)":[85],"tissues,respectively.The":[88],"differences":[89],"between":[90,126],"both":[98],"significantly":[104],"observed":[105,146],"according":[106],"statistical":[109],"analysis":[110],"results.PTEN":[111],"not":[113],"associated":[117],"with":[118],"T":[119],"stage,lymph":[120],"nodes":[121],"metastases.There":[122],"no":[124],"correlation":[125],"tissues.Conclusion":[133],"Reduced":[134],"or":[135],"absent":[136],"high":[141],"tissues,which":[149],"implied":[150],"mutual":[152],"cooperative":[153],"role":[154],"participate":[156],"tumor":[158],"occurrence,progression":[159],"NPC.":[163]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}