{"id":"https://openalex.org/W1277919708","doi":null,"title":"Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major.","display_name":"Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W1277919708","mag":"1277919708","pmid":"https://pubmed.ncbi.nlm.nih.gov/7750991","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1415107"},"language":"en","primary_location":{"id":"pmid:7750991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7750991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1415107/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Xu","raw_affiliation_strings":["Department of Immunology, University of Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109196457","display_name":"F Y Liew","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Y Liew","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":25.8918,"has_fulltext":false,"cited_by_count":173,"citation_normalized_percentile":{"value":0.99712857,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"84","issue":"2","first_page":"173","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmaniasis","display_name":"leishmaniasis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gp63","display_name":"gp63","score":0.9399999976158142},{"id":"https://openalex.org/keywords/major-surface-glycoprotein","display_name":"major surface glycoprotein","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nucleic-acid-vaccines","display_name":"nucleic acid vaccines","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.5550000071525574},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8399999737739563},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":1.0},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7440000176429749},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6287638545036316},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5937914848327637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5628390312194824},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.561488151550293},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4990653991699219},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4874696731567383},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4424174726009369},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4213225543498993},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4105319380760193},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40412503480911255},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3267844319343567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15869635343551636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10467997193336487}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018320","descriptor_name":"Leishmania major","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7750991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7750991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1415107","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1415107/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:1277919708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7750991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1415107","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1415107/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W220113049","https://openalex.org/W1548060537","https://openalex.org/W1650597323","https://openalex.org/W2002022916","https://openalex.org/W2014495927","https://openalex.org/W2018289835","https://openalex.org/W2056877436","https://openalex.org/W2070426326","https://openalex.org/W2084696890","https://openalex.org/W2100837269","https://openalex.org/W2127278205"],"related_works":["https://openalex.org/W2007533642","https://openalex.org/W2308067622","https://openalex.org/W2094945005","https://openalex.org/W7096920734","https://openalex.org/W2944242706","https://openalex.org/W2141351580","https://openalex.org/W2117451755","https://openalex.org/W2342250387","https://openalex.org/W2128721150","https://openalex.org/W2019928997"],"abstract_inverted_index":{"cDNA":[0],"encoding":[1],"the":[2,27,40,52,66,107],"highly":[3],"conserved":[4],"major":[5,11,86,99],"surface":[6],"glycoprotein,":[7],"gp63,":[8],"of":[9,43,49,72],"Leishmania":[10],"was":[12],"cloned,":[13],"together":[14],"with":[15,84,106],"a":[16],"signal":[17],"sequence,":[18],"into":[19,39],"an":[20],"eukaryotic":[21],"expression":[22],"vector,":[23],"pCDNAI,":[24],"which":[25],"carries":[26],"human":[28],"cytomegalovirus":[29],"(CMV)":[30],"promoter.":[31],"This":[32],"construct,":[33],"pCMV/glycoprotein":[34],"63":[35],"(gp63),":[36],"when":[37,82],"injected":[38,105],"skeletal":[41],"muscle":[42,53],"BALB/c":[44],"mice":[45,68,92,104],"expressed":[46],"sustained":[47],"levels":[48],"gp63":[50],"in":[51,88],"tissue":[54],"for":[55],"at":[56],"least":[57],"40":[58],"days.":[59],"Spleen":[60],"and":[61,75],"lymph":[62],"node":[63],"cells":[64],"from":[65],"immunized":[67,91],"produced":[69],"significant":[70,95],"amounts":[71],"interleukin-2":[73],"(IL-2)":[74],"interferon-gamma":[76],"(IFN-gamma)":[77],"but":[78],"no":[79],"detectable":[80],"IL-4":[81],"cultured":[83],"L.":[85,98],"antigens":[87],"vitro.":[89],"The":[90],"also":[93],"developed":[94],"resistance":[96],"against":[97,119],"infection":[100],"compared":[101],"to":[102],"control":[103],"empty":[108],"plasmid.":[109],"These":[110],"results":[111],"suggest":[112],"that":[113],"nucleic":[114],"acid":[115],"vaccine":[116],"is":[117],"effective":[118],"parasite":[120],"infections.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}