{"id":"https://openalex.org/W127755767","doi":"https://doi.org/10.1007/bfb0000704","title":"Use of regulated secretion in protein production from animal cells: An overview","display_name":"Use of regulated secretion in protein production from animal cells: An overview","publication_year":2005,"publication_date":"2005-10-05","ids":{"openalex":"https://openalex.org/W127755767","doi":"https://doi.org/10.1007/bfb0000704","mag":"127755767","pmid":"https://pubmed.ncbi.nlm.nih.gov/1636482"},"language":"en","primary_location":{"id":"doi:10.1007/bfb0000704","doi":"https://doi.org/10.1007/bfb0000704","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bfb0000704","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biochemical Engineering/Biotechnology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W654936079","display_name":"Modern Biochemical Engineering"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091660415","display_name":"Gustavo E. Grampp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. E. Grampp","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139","Department of Chemical Engineering, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049533278","display_name":"Athanassios Sambanis","orcid":"https://orcid.org/0000-0003-0514-089X","observed_orcids":["https://orcid.org/0000-0003-0514-089X"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Sambanis","raw_affiliation_strings":["School of Chemical Engineering, Georgia Institute of Technology, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering, Georgia Institute of Technology, Atlanta, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. N. Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4849,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.7125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":null,"first_page":"35","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.824999988079071},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7960000038146973},{"id":"https://openalex.org/keywords/att-20-cells","display_name":"AtT-20 cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/secretion-kinetics","display_name":"secretion kinetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bioreactor-design","display_name":"bioreactor design","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cell-culture","display_name":"cell culture","score":0.4020000100135803},{"id":"https://openalex.org/keywords/post-translational-processing","display_name":"post-translational processing","score":0.7870000004768372},{"id":"https://openalex.org/keywords/endocrine-hormones","display_name":"endocrine hormones","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8257694244384766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6119179129600525},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5157973766326904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5149367451667786},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5144315361976624},{"id":"https://openalex.org/C67568554","wikidata":"https://www.wikidata.org/wiki/Q385442","display_name":"Downstream processing","level":2,"score":0.4111711382865906},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35481327772140503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24154198169708252},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06373482942581177},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001698","descriptor_name":"Biomedical Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bfb0000704","doi":"https://doi.org/10.1007/bfb0000704","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bfb0000704","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biochemical Engineering/Biotechnology","raw_type":"book-chapter"},{"id":"pmid:1636482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1636482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in biochemical engineering/biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W410898356","https://openalex.org/W592871684","https://openalex.org/W1491459594","https://openalex.org/W1499723666","https://openalex.org/W1522090707","https://openalex.org/W1553310373","https://openalex.org/W1689675417","https://openalex.org/W1965576115","https://openalex.org/W1967086988","https://openalex.org/W1967728340","https://openalex.org/W1968567046","https://openalex.org/W1969259632","https://openalex.org/W1977685486","https://openalex.org/W1984267784","https://openalex.org/W1985810456","https://openalex.org/W1986849002","https://openalex.org/W1987793678","https://openalex.org/W1990009191","https://openalex.org/W1990747840","https://openalex.org/W1996238942","https://openalex.org/W1999455524","https://openalex.org/W2006943139","https://openalex.org/W2008146810","https://openalex.org/W2030345458","https://openalex.org/W2032254922","https://openalex.org/W2038862314","https://openalex.org/W2047374082","https://openalex.org/W2051185783","https://openalex.org/W2056347188","https://openalex.org/W2063042519","https://openalex.org/W2063255017","https://openalex.org/W2068653600","https://openalex.org/W2068654180","https://openalex.org/W2068877244","https://openalex.org/W2074669112","https://openalex.org/W2077792194","https://openalex.org/W2124940322","https://openalex.org/W2145835877","https://openalex.org/W2156602181","https://openalex.org/W2158636606","https://openalex.org/W2159869711","https://openalex.org/W2234104509","https://openalex.org/W2355414246","https://openalex.org/W4205696149"],"related_works":["https://openalex.org/W2124940322","https://openalex.org/W2088165417","https://openalex.org/W7015715470","https://openalex.org/W2047672282","https://openalex.org/W2249253802","https://openalex.org/W4378212194","https://openalex.org/W2022591317","https://openalex.org/W6980683975","https://openalex.org/W192666224","https://openalex.org/W1265006601"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}