{"id":"https://openalex.org/W127321841","doi":null,"title":"In vitro diagnosis of immediate allergic reactions to drugs: an update.","display_name":"In vitro diagnosis of immediate allergic reactions to drugs: an update.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W127321841","mag":"127321841","pmid":"https://pubmed.ncbi.nlm.nih.gov/20461964"},"language":"en","primary_location":{"id":"pmid:20461964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20461964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065314204","display_name":"Cristobalina Mayorga","orcid":"https://orcid.org/0000-0001-8852-8077","observed_orcids":["https://orcid.org/0000-0001-8852-8077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Mayorga","raw_affiliation_strings":["Research Laboratory, Fundaci\u00f3n IMABIS--Carlos Haya Hospital, Malaga, Spain. mayorga.lina@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory, Fundaci\u00f3n IMABIS--Carlos Haya Hospital, Malaga, Spain. mayorga.lina@gmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111986990","display_name":"Maria Luisa Sanz","orcid":"https://orcid.org/0000-0001-6006-4573","observed_orcids":["https://orcid.org/0000-0001-6006-4573"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Sanz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110019298","display_name":"Pedro Manuel Gamboa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Gamboa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103332487","display_name":"Blanca E. Garc\u00eda","orcid":"https://orcid.org/0000-0003-4463-4841","observed_orcids":["https://orcid.org/0000-0003-4463-4841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B E Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000365272","display_name":"Teresa Caballero","orcid":"https://orcid.org/0000-0003-3005-9858","observed_orcids":["https://orcid.org/0000-0003-3005-9858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T Caballero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J M Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048567914","display_name":"Mois\u00e9s Labrador\u2010Horrillo","orcid":"https://orcid.org/0000-0003-3222-2380","observed_orcids":["https://orcid.org/0000-0003-3222-2380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Labrador","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Lahoz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Lahoz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064529971","display_name":"Natividad Longo Areso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Longo Areso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143003711","display_name":"M L\u00f3pez Hoyos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L\u00f3pez Hoyos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5142556489","display_name":"J Mart\u00ednez Quesada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mart\u00ednez Quesada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068337245","display_name":"F. J. Monteseir\u00edn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Monteseir\u00edn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2509,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.95628064,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"103","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/immediate-hypersensitivity","display_name":"immediate hypersensitivity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/in-vitro-diagnosis","display_name":"in vitro diagnosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/specific-ige","display_name":"specific IgE","score":0.8629999756813049},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.925000011920929},{"id":"https://openalex.org/keywords/basophil-activation-test","display_name":"basophil activation test","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-allergy-testing","display_name":"drug allergy testing","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9008561372756958},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8673880696296692},{"id":"https://openalex.org/C2779176990","wikidata":"https://www.wikidata.org/wiki/Q4867824","display_name":"Basophil activation","level":5,"score":0.7700803279876709},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6232991814613342},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6216931939125061},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5557276606559753},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.5532231330871582},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5343773365020752},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5182540416717529},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4643535912036896},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.4238932430744171},{"id":"https://openalex.org/C2777456892","wikidata":"https://www.wikidata.org/wiki/Q107988","display_name":"Basophil","level":4,"score":0.29754412174224854},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08066239953041077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05677276849746704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015549","descriptor_name":"Basophil Degranulation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20461964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20461964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Journal Article"},{"id":"mag:127321841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20461964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W30052907","https://openalex.org/W176970130","https://openalex.org/W598855324","https://openalex.org/W1806522924","https://openalex.org/W1970166909","https://openalex.org/W1971905966","https://openalex.org/W1988224229","https://openalex.org/W1990726458","https://openalex.org/W1991108579","https://openalex.org/W1998727658","https://openalex.org/W2002282539","https://openalex.org/W2006215766","https://openalex.org/W2028190708","https://openalex.org/W2034029800","https://openalex.org/W2035507877","https://openalex.org/W2040943654","https://openalex.org/W2045519039","https://openalex.org/W2047526468","https://openalex.org/W2051411338","https://openalex.org/W2054488432","https://openalex.org/W2055993882","https://openalex.org/W2059554755","https://openalex.org/W2060709102","https://openalex.org/W2064310433","https://openalex.org/W2067683926","https://openalex.org/W2070425004","https://openalex.org/W2072564715","https://openalex.org/W2075032257","https://openalex.org/W2076712285","https://openalex.org/W2077419609","https://openalex.org/W2079602083","https://openalex.org/W2093010162","https://openalex.org/W2094887277","https://openalex.org/W2098665831","https://openalex.org/W2116970925","https://openalex.org/W2117450084","https://openalex.org/W2126346033","https://openalex.org/W2137698208","https://openalex.org/W2138336199","https://openalex.org/W2146797844","https://openalex.org/W2166375729","https://openalex.org/W2181641272","https://openalex.org/W2414147529","https://openalex.org/W2415898223","https://openalex.org/W3174804807"],"related_works":["https://openalex.org/W2987762190","https://openalex.org/W2111378497","https://openalex.org/W4403448534","https://openalex.org/W2412056403","https://openalex.org/W2009301417","https://openalex.org/W2160681474","https://openalex.org/W403246872","https://openalex.org/W4312799019","https://openalex.org/W2803132311","https://openalex.org/W3179738401"],"abstract_inverted_index":{"Evaluation":[0],"of":[1,9,13,21,40,68,87,97,106,121,125,136],"allergic":[2,138],"reactions":[3],"to":[4,25,36,62,113,142],"drugs":[5,63],"is":[6],"difficult":[7],"because":[8],"the":[10,22,27,38,45,50,66,82,95,119,122,126,134,137],"poor":[11],"sensitivity":[12,91],"in":[14,34,41,65,76,114,140,146,148,151],"vivo":[15,42,115,149],"tests,":[16],"which":[17,88],"makes":[18],"controlled":[19],"administration":[20],"drug":[23],"necessary":[24],"confirm":[26],"diagnosis.":[28],"In":[29,44],"vitro":[30,77,152],"tests":[31],"are":[32,60,79],"important":[33],"order":[35,141],"avoid":[37],"risks":[39],"testing.":[43],"present":[46],"review,":[47],"we":[48],"describe":[49],"different":[51],"methods":[52,78],"for":[53,94],"detecting":[54],"immunoglobulin":[55],"(Ig)":[56],"E":[57],"antibodies":[58],"that":[59],"specific":[61,98],"involved":[64],"development":[67],"type":[69],"I":[70],"(immediate)":[71],"reactions.":[72],"The":[73],"2":[74],"main":[75],"immunoassays":[80],"and":[81,92,108,150],"basophil":[83],"activation":[84],"test,":[85],"both":[86,147],"have":[89,110],"sufficient":[90],"specificity":[93],"detection":[96],"IgE":[99],"antibodies,":[100],"although":[101],"with":[102],"a":[103],"limited":[104],"number":[105],"drugs,":[107],"they":[109],"proven":[111],"complementary":[112],"methods.":[116],"We":[117],"show":[118],"importance":[120],"allergological":[123],"workup":[124],"patient":[127],"within":[128],"less":[129],"than":[130],"1":[131],"year":[132],"from":[133],"occurrence":[135],"reaction":[139],"obtain":[143],"positive":[144],"results":[145],"tests.":[153]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
