{"id":"https://openalex.org/W127288442","doi":null,"title":"Abnormal myocardial fluid retention as an early manifestation of ischemic injury.","display_name":"Abnormal myocardial fluid retention as an early manifestation of ischemic injury.","publication_year":1977,"publication_date":"1977-04-01","ids":{"openalex":"https://openalex.org/W127288442","mag":"127288442","pmid":"https://pubmed.ncbi.nlm.nih.gov/139829","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032067"},"language":"en","primary_location":{"id":"pmid:139829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/139829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2032067/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108410707","display_name":"James T. Willerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J T Willerson","raw_affiliation_strings":["University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052067219","display_name":"F Scales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Scales","raw_affiliation_strings":["University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076556117","display_name":"Abhishek Mukherjee","orcid":"https://orcid.org/0000-0001-9071-2295","observed_orcids":["https://orcid.org/0000-0001-9071-2295"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Mukherjee","raw_affiliation_strings":["University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065527393","display_name":"Melvin R. Platt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Platt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110393508","display_name":"G. H. Templeton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G H Templeton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066855958","display_name":"G S Fink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Fink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038526875","display_name":"Louis Maximilian Buja","orcid":"https://orcid.org/0000-0001-8386-7029","observed_orcids":["https://orcid.org/0000-0001-8386-7029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M Buja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.2737,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.97495337,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"87","issue":"1","first_page":"159","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.7310000061988831},{"id":"https://openalex.org/keywords/coronary-artery-occlusion","display_name":"coronary artery occlusion","score":0.8370000123977661},{"id":"https://openalex.org/keywords/interstitial-edema","display_name":"interstitial edema","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cell-volume-regulation","display_name":"cell volume regulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/plasma-membrane-integrity","display_name":"plasma membrane integrity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.6859999895095825},{"id":"https://openalex.org/keywords/nitroglycerin","display_name":"nitroglycerin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.6850000023841858},{"id":"https://openalex.org/keywords/myocardial-ultrastructure","display_name":"myocardial ultrastructure","score":0.5889999866485596},{"id":"https://openalex.org/keywords/canine-heart","display_name":"canine heart","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8057825565338135},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6156191825866699},{"id":"https://openalex.org/C2780393670","wikidata":"https://www.wikidata.org/wiki/Q5172192","display_name":"Coronary occlusion","level":3,"score":0.5910062789916992},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5671356320381165},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.5480674505233765},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4889179766178131},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4147069454193115},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.41110557317733765},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.41004645824432373},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.2073667347431183}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:139829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/139829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2032067","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2032067/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:127288442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/139829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2032067","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2032067/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W60748611","https://openalex.org/W1528492966","https://openalex.org/W1529141639","https://openalex.org/W1545596371","https://openalex.org/W1553292475","https://openalex.org/W1595778460","https://openalex.org/W1635858559","https://openalex.org/W1687842363","https://openalex.org/W1996723509","https://openalex.org/W2030910978","https://openalex.org/W2056471190","https://openalex.org/W2069538047","https://openalex.org/W2103922226","https://openalex.org/W2130887601","https://openalex.org/W2140233303","https://openalex.org/W2146842880","https://openalex.org/W2320563491","https://openalex.org/W2408298820","https://openalex.org/W2410632058","https://openalex.org/W4247382961","https://openalex.org/W7116839963"],"related_works":["https://openalex.org/W2055707052","https://openalex.org/W2397125749","https://openalex.org/W2418721712","https://openalex.org/W67762886","https://openalex.org/W2109132183","https://openalex.org/W2090912767","https://openalex.org/W7120747050","https://openalex.org/W2406977375","https://openalex.org/W2140233303","https://openalex.org/W2032536459"],"abstract_inverted_index":{"Fifty-seven":[0],"isolated,":[1],"blood":[2,329],"perfused,":[3],"continuously":[4],"weighed":[5],"canine":[6],"hearts":[7,40,50],"have":[8],"been":[9],"utilized":[10],"to":[11,234,243,260,316,332],"study":[12,52],"the":[13,31,42,54,110,148,201,218,222,253,270,285,322,333],"development":[14,178,334],"of":[15,38,48,53,57,67,81,92,103,112,129,135,163,179,187,252,269,308,335],"abnormal":[16,180,223,323],"myocardial":[17,22,181,224,337],"fluid":[18,182,225,295,324],"retention":[19,183,226,325],"during":[20],"early":[21,306],"ischemic":[23,105,149,202,309],"injury.":[24],"Inflatable":[25],"balloon":[26],"catheters":[27],"were":[28,174],"positioned":[29],"around":[30],"left":[32,44],"anterior":[33],"descending":[34],"coronary":[35,46,58,94,130,236,248,254,328,342],"arteries":[36,47],"(LAD)":[37],"54":[39],"or":[41,77,213],"proximal":[43],"circumflex":[45],"three":[49],"for":[51,321,344],"following":[55,250,267],"intervals":[56],"occlusion:":[59],"a)":[60],"10":[61],"minutes":[62,66,71,80,86,91,128,134,186,258,281,346],"followed":[63,72,311],"by":[64,73,78,312],"20":[65,79,133],"reflow,":[68,82,136,313],"b)":[69],"40":[70,127,185,257],"either":[74,210],"no":[75,206,353,358],"reflow":[76],"and":[83,97,118,132,155,159,161,240,259,274,293,297,357],"c)":[84],"60":[85,90,345],"without":[87],"reflow.":[88,283],"After":[89,126],"fixed":[93,341],"occlusion,":[95],"histologic":[96],"ultrastructural":[98],"examination":[99],"revealed":[100],"mild":[101,349],"swelling":[102,162,351],"many":[104],"cardiac":[106,115,138,164],"muscle":[107,165],"cells":[108],"in":[109,122,142,147,170,191,197,200,209,217,227,301,326,348,362],"absence":[111],"interstitial":[113,153,294,355],"edema,":[114],"weight":[116,139],"gain,":[117],"obvious":[119,359],"structural":[120,168,299,360],"defects":[121,169,300,361],"cell":[123,171,290,302,363],"membrane":[124,172,303,364],"integrity.":[125,365],"occlusion":[131,189,255,271,343],"significant":[137,195,207,354],"gain":[140],"occurred":[141,190],"association":[143,192],"with":[144,193,205,238],"characteristic":[145],"alterations":[146],"region,":[150],"including":[151],"widespread":[152],"edema":[154,356],"focal":[156,298],"vascular":[157],"congestion":[158],"hemorrhage":[160],"cells.":[166],"Focal":[167],"integrity":[173,304],"also":[175],"noted.":[176],"The":[177],"after":[184,256,282],"LAD":[188],"a":[194,245,318],"reduction":[196],"sodium-potassium-ATPase":[198],"activity":[199,216],"area,":[203],"but":[204,314,352],"alteration":[208],"creatine":[211],"phosphokinase":[212],"citrate":[214],"synthase":[215],"same":[219],"region.":[220],"Despite":[221],"these":[228],"hearts,":[229],"it":[230],"was":[231,277],"possible":[232],"pharmacologically":[233],"vasodilate":[235],"vessels":[237],"adenosine":[239,273],"nitroglycerin":[241,275],"infusion":[242,276],"maintain":[244],"consistently":[246],"high":[247],"flow":[249,265,330],"release":[251,268],"even":[261],"exceed":[262],"initial":[263],"hyperemic":[264],"values":[266],"when":[272],"delayed":[278],"until":[279],"15":[280],"Thus,":[284],"data":[286],"indicate":[287],"that":[288],"impaired":[289],"volume":[291],"regulation":[292],"accumulation":[296],"are":[305],"manifestations":[307],"injury":[310],"fail":[315],"establish":[317],"major":[319],"role":[320],"altering":[327],"prior":[331],"extensive":[336],"necrosis.":[338],"In":[339],"contrast,":[340],"results":[347],"intracellular":[350]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
