{"id":"https://openalex.org/W127072070","doi":null,"title":"Biochemistry of migraine.","display_name":"Biochemistry of migraine.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W127072070","mag":"127072070","pmid":"https://pubmed.ncbi.nlm.nih.gov/1379706"},"language":"en","primary_location":{"id":"pmid:1379706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1379706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologie-biologie","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"M D Ferrari","raw_affiliation_strings":["Department of Neurology, Leiden University Hospital, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Leiden University Hospital, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039941295"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":null,"apc_paid":null,"fwci":2.5119,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88057126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"40","issue":"4","first_page":"287","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.7450000047683716},{"id":"https://openalex.org/keywords/serotonin-metabolism","display_name":"serotonin metabolism","score":0.8140000104904175},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.9670000076293945},{"id":"https://openalex.org/keywords/met-enkephalin","display_name":"met-enkephalin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tension-type-headache","display_name":"tension-type headache","score":0.7210000157356262},{"id":"https://openalex.org/keywords/migraine-with-aura","display_name":"migraine with aura","score":0.7689999938011169},{"id":"https://openalex.org/keywords/migraine-without-aura","display_name":"migraine without aura","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hormonal-fluctuations","display_name":"hormonal fluctuations","score":0.8259999752044678},{"id":"https://openalex.org/keywords/vasoactive-peptides","display_name":"vasoactive peptides","score":0.9909999966621399},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8659999966621399},{"id":"https://openalex.org/keywords/sympathetic-hyperactivity","display_name":"sympathetic hyperactivity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.7369999885559082},{"id":"https://openalex.org/keywords/platelet-free-plasma","display_name":"platelet-free plasma","score":0.8519999980926514},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cortical-spreading-depression","display_name":"cortical spreading depression","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.9657332897186279},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.839514970779419},{"id":"https://openalex.org/C122356138","wikidata":"https://www.wikidata.org/wiki/Q461576","display_name":"Cortical spreading depression","level":3,"score":0.8234390616416931},{"id":"https://openalex.org/C2776497919","wikidata":"https://www.wikidata.org/wiki/Q739481","display_name":"Migraine with aura","level":4,"score":0.6146171689033508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47814950346946716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4681086242198944},{"id":"https://openalex.org/C2776824294","wikidata":"https://www.wikidata.org/wiki/Q18344428","display_name":"Catecholaminergic","level":3,"score":0.45720037817955017},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4537908136844635},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4156320095062256},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.07013672590255737}],"mesh":[{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004744","descriptor_name":"Enkephalin, Methionine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1379706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1379706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologie-biologie","raw_type":"Journal Article"},{"id":"mag:127072070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1379706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588548628","https://openalex.org/W2045530969","https://openalex.org/W4285588028","https://openalex.org/W2155857448","https://openalex.org/W2064959107","https://openalex.org/W414632590","https://openalex.org/W61029516","https://openalex.org/W2110876049","https://openalex.org/W2613227866","https://openalex.org/W6989601865"],"abstract_inverted_index":{"The":[0,20],"biochemistry":[1],"of":[2,42,51,67,114],"migraine":[3,52,69,149,164,170],"is":[4,131],"complex.":[5],"Many":[6],"contradictory":[7],"or":[8],"never":[9],"replicated":[10],"findings":[11],"in":[12,23,56,83,117,133,181],"often":[13],"small":[14],"patient":[15],"groups":[16],"have":[17,31],"been":[18],"published.":[19],"following":[21],"observations":[22],"the":[24,47,68,107,118,122,127,174,194],"platelet-free":[25],"plasma":[26,195],"and":[27,35,60,97,135,152,160,167,191,196],"urine":[28,197],"appear":[29],"to":[30,46,77,92,105,193],"some":[32],"solid":[33],"basis":[34],"will":[36,177,183],"be":[37,88,178,184],"discussed:":[38],"1)":[39],"systemic":[40],"derangement":[41],"5-HT":[43],"metabolism,":[44],"relevant":[45,132],"peripheral":[48],"vascular":[49],"component":[50],"pathophysiology,":[53],"2)":[54],"changes":[55,113,138],"neuroexcitatory":[57],"amino":[58],"acids":[59],"magnesium,":[61],"which":[62,86,102],"may":[63,87],"reflect":[64],"a":[65,89],"predisposition":[66],"patient,":[70],"notably":[71],"those":[72],"having":[73],"attacks":[74],"with":[75,148,154,163,165,169],"aura,":[76],"develop":[78],"spreading":[79],"depression,":[80],"3)":[81],"alterations":[82],"methionine-enkephalin":[84],"levels,":[85],"useful":[90],"marker":[91],"discriminate":[93],"between":[94,146,161],"tension":[95,155],"headache":[96,156],"migraine,":[98,134],"4)":[99],"hormonal":[100],"fluctuations":[101],"seem":[103],"important":[104],"set":[106],"threshold":[108],"for":[109],"an":[110],"attack,":[111],"5)":[112],"vasoactive":[115],"peptides":[116],"cranio-vascular":[119],"circulation,":[120],"providing":[121],"first":[123],"human":[124],"evidence":[125],"that":[126],"trigemino-vascular":[128],"system":[129],"indeed":[130],"6)":[136],"catecholaminergic":[137],"suggesting":[139],"sympathetic":[140],"overactivity.":[141],"Finally":[142],"distinct":[143],"biochemical":[144],"differences":[145],"patients":[147,153,162,168],"without":[150,171],"aura":[151,166,172],"on":[157,173],"one":[158],"hand,":[159],"other":[175],"hand":[176],"emphasized.":[179],"Findings":[180],"platelets":[182],"discussed":[185],"only":[186],"if":[187],"they":[188],"are":[189],"complementary":[190],"supportive":[192],"data.":[198]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}