{"id":"https://openalex.org/W126960128","doi":"https://doi.org/10.1515/9783110807271.107","title":"Human prostate cancer progression models and therapeutic intervention","display_name":"Human prostate cancer progression models and therapeutic intervention","publication_year":2013,"publication_date":"2013-05-30","ids":{"openalex":"https://openalex.org/W126960128","doi":"https://doi.org/10.1515/9783110807271.107","mag":"126960128","pmid":"https://pubmed.ncbi.nlm.nih.gov/9436028"},"language":"en","primary_location":{"id":"doi:10.1515/9783110807271.107","doi":"https://doi.org/10.1515/9783110807271.107","is_oa":false,"landing_page_url":"https://doi.org/10.1515/9783110807271.107","pdf_url":null,"source":{"id":"https://openalex.org/S4306463091","display_name":"De Gruyter eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of Prostate Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2340695170","display_name":"Molecular Biology of Prostate Cancer"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/116063/1/43_815.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010686592","display_name":"Leland W.K. Chung","orcid":"https://orcid.org/0000-0003-0072-6939","observed_orcids":["https://orcid.org/0000-0003-0072-6939","https://orcid.org/0000-0001-9445-3569"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. W. K. Chung","raw_affiliation_strings":["Department of Urology, University of Virginia Health Sciences Center, Charlottesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Virginia Health Sciences Center, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111365848","display_name":"Chinghai H. Kao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Kao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009525695","display_name":"R A Sikes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. A. Sikes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110400725","display_name":"Haiyen E. Zhau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. E. Zhau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7782,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.85245098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"43","issue":"11","first_page":"815","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.9049999713897705},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.6489999890327454},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/prostate-specific-antigen-promoter","display_name":"prostate-specific antigen promoter","score":0.8059999942779541},{"id":"https://openalex.org/keywords/osteocalcin-promoter","display_name":"osteocalcin promoter","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7680000066757202},{"id":"https://openalex.org/keywords/acyclovir-prodrug","display_name":"acyclovir prodrug","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8142956495285034},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7924479246139526},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6676252484321594},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5789276361465454},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4950956404209137},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4789995849132538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47044509649276733},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4408535957336426},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.41238340735435486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35323405265808105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34219878911972046}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1515/9783110807271.107","doi":"https://doi.org/10.1515/9783110807271.107","is_oa":false,"landing_page_url":"https://doi.org/10.1515/9783110807271.107","pdf_url":null,"source":{"id":"https://openalex.org/S4306463091","display_name":"De Gruyter eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of Prostate Cancer","raw_type":"book-chapter"},{"id":"pmid:9436028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9436028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hinyokika kiyo. Acta urologica Japonica","raw_type":"Journal Article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/116063","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/116063","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/116063/1/43_815.pdf","source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"departmental bulletin paper"}],"best_oa_location":{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/116063","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/116063","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/116063/1/43_815.pdf","source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"departmental bulletin paper"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2118442237","display_name":null,"funder_award_id":"R01-CA64863","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4828237061","display_name":"PROSTATE CANCER METASTASIS--ROLE OF STROMA","funder_award_id":"5r01ca064863-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W126960128.pdf","grobid_xml":"https://content.openalex.org/works/W126960128.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7208152070","https://openalex.org/W7100577181","https://openalex.org/W2088469222","https://openalex.org/W1985755415","https://openalex.org/W1581074473","https://openalex.org/W2082267512","https://openalex.org/W348661087","https://openalex.org/W2156854438","https://openalex.org/W4225400778","https://openalex.org/W2017757468"],"abstract_inverted_index":{"Our":[0],"laboratory":[1],"has":[2,410],"developed":[3,306],"two":[4],"cellular":[5,23,48],"models":[6,397],"of":[7,109,138,164,183,210,214,248,252,276,295,313,337,401],"human":[8,26,198,286,353,365],"prostate":[9,14,27,52,101,199,243,287,299,354,366,392],"cancer":[10,15,102,200,288,300,355,367,393],"progression.":[11],"The":[12,37,95],"LNCaP":[13,33,40],"progression":[16,201],"model":[17,97,202],"is":[18,98,317],"based":[19],"upon":[20,47],"the":[21,74,79,82,86,106,136,140,146,158,188,208,215,246,250,274,277,292,311,335,399,408],"well-known":[22],"interaction":[24,49],"between":[25],"or":[28,53,131,145],"bone":[29,54,296,394,409],"stromal":[30],"cells":[31,34,41,103,142,160,356],"and":[32,44,68,85,118,124,155,167,192,226,237,263,340,346,404],"in":[35,65,90,127,143,148,241,284,344,347,396,407],"vivo.":[36,348],"marginally":[38],"tumorigenic":[39,43],"acquired":[42,69],"metastatic":[45,70,113,174],"potential":[46,71],"with":[50,112],"either":[51,128,139],"fibroblasts.":[55],"A":[56],"subline":[57],"termed":[58],"C4-2":[59,405],"was":[60,150,330],"observed":[61,350],"to":[62,78,180,206,332,374,390],"grow":[63],"readily":[64],"castrated":[66,133],"animals":[67],"spreading":[72],"from":[73,105],"primary":[75],"tumor":[76,125,141,159,232,244],"site":[77],"lymph":[80],"node,":[81],"seminal":[83],"vesicles,":[84],"axial":[87],"skeleton,":[88],"resulting":[89],"an":[91,116,387],"intense":[92],"osteoblastic":[93],"reaction.":[94],"second":[96],"ARCaP,":[99],"where":[100,310,398],"derived":[104],"ascites":[107],"fluid":[108],"a":[110,129,132,181,197,204,257,264,307,320,323,379],"man":[111],"disease":[114],"exhibited":[115],"Androgen-":[117],"estrogen-Repressed":[119],"Prostate":[120],"Cancer":[121],"cell":[122,368],"growth":[123,137,336,400],"formation":[126],"hormone-deficient":[130],"environment.":[134],"However,":[135],"vitro":[144,345],"tumors":[147,342,406],"vivo":[149],"suppressed":[151],"by":[152,319],"both":[153,343],"estrogen":[154],"androgen.":[156],"While":[157],"expressed":[161,358],"low":[162],"levels":[163,362],"androgen":[165],"receptor":[166],"prostate-specific":[168,260],"antigen":[169,261],"(PSA),":[170],"they":[171],"were":[172,185,239],"highly":[173],"when":[175],"inoculated":[176],"orthotopically.":[177],"Distant":[178],"metastases":[179],"number":[182],"organs":[184],"detected,":[186],"including":[187],"liver,":[189],"lung,":[190],"kidney,":[191],"bone.":[193],"We":[194,349,370],"have":[195,304,371],"employed":[196],"as":[203,223,386],"system":[205],"study":[207,216],"efficacy":[209],"gene":[211],"therapy.":[212],"Results":[213],"show":[217],"that":[218,351,376],"whereas":[219],"universal":[220],"promoters,":[221],"such":[222],"Cytomegalovirus":[224],"(CMV)":[225],"Rous":[227],"Sarcoma":[228],"Virus":[229],"(RSV)":[230],"promoter-driven":[231],"suppressors":[233],"(e.g.":[234],"p53,":[235],"p21,":[236],"p16),":[238],"effective":[240,388],"inhibiting":[242],"growth,":[245,302],"advantages":[247],"driving":[249],"expression":[251,312],"therapeutic":[253,314],"toxic":[254,315],"genes":[255,316],"using":[256],"tissue-specific":[258,267,324],"promoter":[259],"(PSA)":[262],"tumor--but":[265,321],"not":[266,322],"promoter,":[268,279],"osteocalcin":[269],"(OC),":[270],"are":[271],"preferred.":[272],"In":[273],"case":[275],"PSA":[278],"we":[280,303],"can":[281],"achieve":[282],"cell-kill":[283],"PSA-producing":[285],"cells.":[289],"To":[290],"circumvent":[291],"supporting":[293],"role":[294],"stroma":[297],"for":[298],"epithelial":[301],"recently":[305],"novel":[308],"concept":[309],"driven":[318],"OC":[325],"promoter.":[326],"Osteocalcin-thymidine":[327],"kinase":[328],"(OC-TK)":[329],"found":[331],"efficiently":[333],"eradicate":[334],"osteosarcoma,":[338],"prostate,":[339],"brain":[341],"androgen-independent":[352,402],"lines":[357],"OC-TK":[359],"at":[360],"higher":[361],"than":[363],"androgen-dependent":[364],"lines.":[369],"obtained":[372],"data":[373],"suggest":[375],"Ad-OC-TK":[377],"plus":[378],"pro-drug":[380],"acyclovir":[381],"(ACV)":[382],"may":[383],"be":[384],"used":[385],"therapy":[389],"treat":[391],"metastasis":[395],"PC-3":[403],"occurred.":[411]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}