{"id":"https://openalex.org/W126941526","doi":null,"title":"Scopolamine patch to prevent seasickness: clinical response vs. plasma concentration in sailors.","display_name":"Scopolamine patch to prevent seasickness: clinical response vs. plasma concentration in sailors.","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W126941526","mag":"126941526","pmid":"https://pubmed.ncbi.nlm.nih.gov/16110693"},"language":"en","primary_location":{"id":"pmid:16110693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16110693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081489769","display_name":"Amnon Gil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150803","display_name":"Israel Defense Forces Medical Corps","ror":"https://ror.org/05w1yqq10","country_code":"IL","type":"government","lineage":["https://openalex.org/I4210150803"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amnon Gil","raw_affiliation_strings":["Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel. gilefr@bezeqint.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel. gilefr@bezeqint.net","institution_ids":["https://openalex.org/I4210150803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052820854","display_name":"Zohar Nachum","orcid":"https://orcid.org/0000-0002-2118-1010","observed_orcids":["https://orcid.org/0000-0002-2118-1010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zohar Nachum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058366292","display_name":"Shlomit Dachir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shlomit Dachir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shira Chapman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shira Chapman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111851740","display_name":"Aharon Levy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aharon Levy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013393849","display_name":"Avi Shupak","orcid":"https://orcid.org/0000-0002-2056-3535","observed_orcids":["https://orcid.org/0000-0002-2056-3535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avi Shupak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016547009","display_name":"Yochai Adir","orcid":"https://orcid.org/0000-0002-3126-4418","observed_orcids":["https://orcid.org/0000-0002-3126-4418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yochai Adir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102745437","display_name":"Dror Tal","orcid":"https://orcid.org/0000-0002-8111-0601","observed_orcids":["https://orcid.org/0000-0002-8111-0601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dror Tal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0372,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.75664366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"76","issue":"8","first_page":"766","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scopolamine","display_name":"scopolamine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/seasickness","display_name":"seasickness","score":0.9340000152587891},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.6000000238418579},{"id":"https://openalex.org/keywords/nonresponders","display_name":"non-responders","score":0.7170000076293945},{"id":"https://openalex.org/keywords/sailors","display_name":"sailors","score":0.6299999952316284},{"id":"https://openalex.org/keywords/naval-crew","display_name":"naval crew","score":0.5590000152587891},{"id":"https://openalex.org/keywords/skin-absorption","display_name":"percutaneous absorption","score":0.6570000052452087},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2778576352","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine","level":2,"score":0.8960211277008057},{"id":"https://openalex.org/C2779336972","wikidata":"https://www.wikidata.org/wiki/Q309067","display_name":"Motion sickness","level":2,"score":0.6858760714530945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6303176283836365},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5213214755058289},{"id":"https://openalex.org/C2909050532","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine Hydrobromide","level":4,"score":0.4525352120399475},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.43953824043273926},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.412304162979126},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3615584671497345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22986933588981628},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10710093379020691},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008889","descriptor_name":"Military Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16110693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16110693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Clinical Trial"},{"id":"mag:126941526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16110693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W88260675","https://openalex.org/W2089528311","https://openalex.org/W47598414","https://openalex.org/W2444495970","https://openalex.org/W126224949","https://openalex.org/W2065969448","https://openalex.org/W2398017010","https://openalex.org/W2053855264","https://openalex.org/W2127469418","https://openalex.org/W2086966364"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Scopolamine":[1,123],"is":[2,62],"highly":[3],"effective":[4],"for":[5,64,254],"the":[6,20,26,39,44,59,65,69,104,135,200,203,216,220,244,255],"treatment":[7,256],"of":[8,22,36,41,77,137,202,257],"seasickness.":[9],"Nevertheless,":[10],"transdermal":[11,249],"therapeutic":[12,53,85],"system":[13],"(TTS)":[14],"scopolamine,":[15],"despite":[16],"high":[17],"compliance":[18],"on":[19,148],"part":[21],"persons":[23],"treated":[24,80],"by":[25,81,91,242],"drug,":[27],"fails":[28],"to":[29,236],"provide":[30],"protection":[31],"against":[32],"seasickness":[33,168],"in":[34,49,58,68,103,167,199,219,240],"26-38%":[35],"patients.":[37],"To":[38,133],"best":[40],"our":[42],"knowledge,":[43],"correlation":[45],"between":[46],"scopolamine":[47,99,120,179,197,238],"levels":[48,124,239],"plasma":[50,201,241],"and":[51,111,181],"its":[52],"effect":[54],"under":[55],"sailing":[56],"conditions":[57],"open":[60],"sea":[61,88,176],"investigated":[63],"first":[66],"time":[67],"present":[70],"study.":[71],"METHODS:":[72],"Subjects":[73,155],"were":[74,109,125,142,156],"61":[75],"crewmembers":[76],"naval":[78],"vessels":[79],"TTS":[82,98,178],"scopolamine.":[83],"The":[84,195],"response":[86],"at":[87,162,175,192],"was":[89,101,212],"documented":[90],"questionnaire.":[92],"During":[93],"a":[94,97,164],"period":[95],"ashore,":[96],"patch":[100,121,153],"applied":[102],"same":[105],"subjects.":[106],"Blood":[107],"samples":[108,141],"taken":[110,143],"an":[112,128],"adverse":[113],"effects":[114],"questionnaire":[115],"completed":[116],"8":[117],"h":[118],"after":[119,151],"application.":[122],"determined":[126],"using":[127],"established":[129],"radio-receptor":[130],"assay":[131],"procedure.":[132],"verify":[134],"reproducibility":[136],"these":[138],"measurements,":[139],"blood":[140],"twice":[144],"from":[145],"most":[146],"subjects,":[147],"separate":[149],"days":[150],"different":[152],"applications.":[154],"divided":[157],"into":[158],"\"responders,\"":[159],"who":[160,183],"reported":[161],"least":[163],"moderate":[165],"decrease":[166],"severity":[169],"compared":[170],"with":[171],"their":[172],"previous":[173],"experience":[174],"without":[177],"therapy,":[180],"\"non-responders,\"":[182],"had":[184],"only":[185],"slight":[186],"symptomatic":[187],"relief":[188,191],"or":[189,247],"no":[190],"all.":[193],"RESULTS:":[194],"mean":[196,217],"concentration":[198],"37":[204],"responders":[205],"(156.77":[206],"+/-":[207,224],"77.03":[208],"pg":[209,226],"x":[210,227],"ml(-1))":[211],"significantly":[213],"higher":[214],"than":[215],"level":[218],"24":[221],"non-responders":[222],"(97.03":[223],"73.34":[225],"ml(-1);":[228],"p":[229],"=":[230],"0.005,":[231],"simple":[232],"t-test).":[233],"CONCLUSIONS:":[234],"Attempts":[235],"increase":[237],"increasing":[243],"drug":[245],"dosage":[246],"improving":[248],"absorption":[250],"should":[251],"be":[252],"considered":[253],"\"non-responders\".":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
