{"id":"https://openalex.org/W1267629946","doi":null,"title":"Aktivierung des Akt/FoxO-Signalweges durch Insulin und Schwermetallionen: transkriptionelle Regulation der Biosynthese von Selenoprotein P","display_name":"Aktivierung des Akt/FoxO-Signalweges durch Insulin und Schwermetallionen: transkriptionelle Regulation der Biosynthese von Selenoprotein P","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1267629946","mag":"1267629946"},"language":"de","primary_location":{"id":"pmh:oai:docserv.uni-duesseldorf.de:3443","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=3443","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Philippe Walter","orcid":"https://orcid.org/0000-0002-1804-8374","observed_orcids":["https://orcid.org/0000-0002-1804-8374"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Philippe Walter","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1804-8374","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.3781999945640564,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenoprotein-p","display_name":"selenoprotein P","score":0.8330000042915344},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6420000195503235},{"id":"https://openalex.org/keywords/heavy-metal-ions","display_name":"heavy metal ions","score":0.9620000123977661},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.46700000762939453},{"id":"https://openalex.org/keywords/astrocytoma-cells","display_name":"astrocytoma cells","score":0.7739999890327454},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.7929999828338623},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.628000020980835},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7350000143051147},{"id":"https://openalex.org/keywords/promoter-activity","display_name":"promoter activity","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.743159294128418},{"id":"https://openalex.org/C2776841403","wikidata":"https://www.wikidata.org/wiki/Q2745644","display_name":"Selenoprotein","level":5,"score":0.7161534428596497},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6701229214668274},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.51311856508255},{"id":"https://openalex.org/C2909795905","wikidata":"https://www.wikidata.org/wiki/Q7447908","display_name":"Selenoprotein P","level":5,"score":0.48650163412094116},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.24086704850196838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1770513355731964},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.12982803583145142},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11641934514045715},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.09076830744743347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07657304406166077}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:docserv.uni-duesseldorf.de:3443","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=3443","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:1267629946","doi":null,"is_oa":false,"landing_page_url":"https://d-nb.info/98042660X/34","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":166,"referenced_works":["https://openalex.org/W1479895549","https://openalex.org/W1509669696","https://openalex.org/W1517762451","https://openalex.org/W1537948347","https://openalex.org/W1549643599","https://openalex.org/W1572963091","https://openalex.org/W1617532721","https://openalex.org/W1625966995","https://openalex.org/W1631908837","https://openalex.org/W1641384127","https://openalex.org/W1726025741","https://openalex.org/W1775749144","https://openalex.org/W1811191752","https://openalex.org/W1858533191","https://openalex.org/W1877188956","https://openalex.org/W1924557165","https://openalex.org/W1933984510","https://openalex.org/W1965947775","https://openalex.org/W1966544705","https://openalex.org/W1966597352","https://openalex.org/W1971857747","https://openalex.org/W1974268113","https://openalex.org/W1976050844","https://openalex.org/W1976124229","https://openalex.org/W1978138528","https://openalex.org/W1978559408","https://openalex.org/W1979147887","https://openalex.org/W1985425785","https://openalex.org/W1990660710","https://openalex.org/W1991080848","https://openalex.org/W1995008569","https://openalex.org/W1996200651","https://openalex.org/W1996695017","https://openalex.org/W1997307819","https://openalex.org/W1997685804","https://openalex.org/W1999163644","https://openalex.org/W2001287121","https://openalex.org/W2001505200","https://openalex.org/W2001604240","https://openalex.org/W2003779663","https://openalex.org/W2005321199","https://openalex.org/W2005867401","https://openalex.org/W2009062734","https://openalex.org/W2011198909","https://openalex.org/W2011785467","https://openalex.org/W2014575062","https://openalex.org/W2014784152","https://openalex.org/W2017698275","https://openalex.org/W2017882868","https://openalex.org/W2020070250","https://openalex.org/W2021519965","https://openalex.org/W2022899991","https://openalex.org/W2023973783","https://openalex.org/W2024306318","https://openalex.org/W2024923170","https://openalex.org/W2026780996","https://openalex.org/W2027629550","https://openalex.org/W2030135352","https://openalex.org/W2030720692","https://openalex.org/W2031441432","https://openalex.org/W2033797333","https://openalex.org/W2034103943","https://openalex.org/W2035104292","https://openalex.org/W2035258932","https://openalex.org/W2036822121","https://openalex.org/W2036837630","https://openalex.org/W2037341437","https://openalex.org/W2038988941","https://openalex.org/W2039037322","https://openalex.org/W2041771374","https://openalex.org/W2043167829","https://openalex.org/W2043690043","https://openalex.org/W2046623154","https://openalex.org/W2046989794","https://openalex.org/W2047440104","https://openalex.org/W2049009766","https://openalex.org/W2049361712","https://openalex.org/W2049739654","https://openalex.org/W2051028757","https://openalex.org/W2051088635","https://openalex.org/W2052908726","https://openalex.org/W2053174155","https://openalex.org/W2054193823","https://openalex.org/W2055893161","https://openalex.org/W2056388945","https://openalex.org/W2057386631","https://openalex.org/W2057713336","https://openalex.org/W2058138221","https://openalex.org/W2058924545","https://openalex.org/W2060001443","https://openalex.org/W2060194897","https://openalex.org/W2062390485","https://openalex.org/W2062629127","https://openalex.org/W2063098376","https://openalex.org/W2063455047","https://openalex.org/W2063858796","https://openalex.org/W2067799923","https://openalex.org/W2068406884","https://openalex.org/W2069414088","https://openalex.org/W2069969811","https://openalex.org/W2069988949","https://openalex.org/W2070139659","https://openalex.org/W2070732456","https://openalex.org/W2071527810","https://openalex.org/W2076262819","https://openalex.org/W2076992251","https://openalex.org/W2077435537","https://openalex.org/W2081359005","https://openalex.org/W2084696983","https://openalex.org/W2084986953","https://openalex.org/W2088145955","https://openalex.org/W2090759987","https://openalex.org/W2092063619","https://openalex.org/W2092846222","https://openalex.org/W2094231976","https://openalex.org/W2096166220","https://openalex.org/W2096576561","https://openalex.org/W2097767970","https://openalex.org/W2097948853","https://openalex.org/W2099364141","https://openalex.org/W2099409085","https://openalex.org/W2100393234","https://openalex.org/W2100837269","https://openalex.org/W2101357976","https://openalex.org/W2102274260","https://openalex.org/W2104109524","https://openalex.org/W2106119346","https://openalex.org/W2108958930","https://openalex.org/W2113002082","https://openalex.org/W2113132658","https://openalex.org/W2113275211","https://openalex.org/W2113999599","https://openalex.org/W2114360920","https://openalex.org/W2114927063","https://openalex.org/W2120253152","https://openalex.org/W2120939161","https://openalex.org/W2121181558","https://openalex.org/W2123401855","https://openalex.org/W2123868590","https://openalex.org/W2124898423","https://openalex.org/W2125481927","https://openalex.org/W2127337885","https://openalex.org/W2133792873","https://openalex.org/W2137035181","https://openalex.org/W2137720344","https://openalex.org/W2137771689","https://openalex.org/W2142842603","https://openalex.org/W2144634347","https://openalex.org/W2147114673","https://openalex.org/W2149124673","https://openalex.org/W2150456795","https://openalex.org/W2158551180","https://openalex.org/W2158889317","https://openalex.org/W2160547697","https://openalex.org/W2162857699","https://openalex.org/W2165863663","https://openalex.org/W2166525118","https://openalex.org/W2168433858","https://openalex.org/W2170138349","https://openalex.org/W2171391341","https://openalex.org/W2173725245","https://openalex.org/W2312843964","https://openalex.org/W2339374716","https://openalex.org/W2388163742","https://openalex.org/W2420350420","https://openalex.org/W2741185046"],"related_works":["https://openalex.org/W1978522093","https://openalex.org/W2091611565","https://openalex.org/W2059899830","https://openalex.org/W2539352854","https://openalex.org/W2529191351","https://openalex.org/W1978325313","https://openalex.org/W3173423353","https://openalex.org/W4220865388","https://openalex.org/W1966121205","https://openalex.org/W1983413366"],"abstract_inverted_index":{"Der":[0],"Akt/FoxO-Signalweg":[1],"reguliert":[2],"in":[3,94,126,151],"menschlichen":[4],"Zellen":[5],"das":[6],"Gleichgewicht":[7],"zwischen":[8,358],"Proliferation":[9],"und":[10,37,138,307,333,342,360],"Apoptose.":[11],"Durch":[12],"FoxO-Transkriptionsfaktoren":[13,339],"induzierte":[14],"Stimulation":[15],"der":[16,25,64,92,109,111,118,167,185,190,207,215,239,304,345],"Synthese":[17],"antioxidativer":[18],"Enzyme":[19],"sorgt":[20],"dabei":[21],"fur":[22,88,179],"einen":[23,356],"Schutz":[24],"Zelle":[26],"vor":[27],"reaktiven":[28],"Sauerstoffspezies,":[29],"die":[30,121,142,153,188,196,221,343],"zur":[31,53,165,230,256,281],"oxidativen":[32],"Schadigung":[33],"von":[34,59,123,155,163,170,192,206,217,247,258,275,283,290,297,331,338],"Biomolekulen":[35],"fuhren":[36],"somit":[38,269],"Zelltod":[39],"oder":[40,249,253,279],"Karzinogenese":[41],"Vorschub":[42],"leisten":[43],"konnen.":[44],"Die":[45,198,336],"Identifizierung":[46],"neuer":[47],"Zielgene":[48],"sowie":[49,113],"bisher":[50],"unbekannter":[51],"Stimuli":[52],"Aktivierung":[54,162,257],"dieses":[55],"Signalweges":[56],"sind":[57],"daher":[58],"grosem":[60],"Interesse.":[61],"Im":[62],"Rahmen":[63],"vorliegenden":[65,240],"Arbeit":[66,241],"konnte":[67,146,212,318],"mit":[68,184,202,251,254,277,292],"dem":[69],"Gen":[70],"des":[71,77,182,200,299,308,314,347],"Selenoproteins":[72,315,351],"P":[73,82,125,157,194,219,352],"ein":[74,84],"neues":[75],"Zielgen":[76,311],"Akt/FoxO-Signalweges":[78],"identifiziert":[79,137],"werden.":[80],"Selenoprotein":[81,124,132,156,193,218],"ist":[83],"Protein,":[85],"welches":[86,160],"sowohl":[87],"den":[89],"Selentransport":[90],"aus":[91],"Leber":[93,231],"extrahepatische":[95],"Gewebe":[96],"verantwortlich":[97],"ist,":[98],"als":[99,265,300,310],"auch":[100,147,266,329],"selber":[101],"antioxidative":[102],"Eigenschaften":[103],"besitzt.":[104],"Es":[105,145],"wurde":[106,242],"auf":[107,114,141],"Ebene":[108],"Promoteraktivitat,":[110],"Transkription":[112],"Proteinebene":[115],"nachgewiesen,":[116,244],"dass":[117,150,245,321],"Transkriptionsfaktor":[119],"FoxO1a":[120,171,232,354],"Biosynthese":[122],"Leberzellen":[127,152],"stimuliert.":[128],"Dabei":[129,317],"wurden":[130],"im":[131,228,348],"P-Promoter":[133],"zwei":[134],"FoxO-bindende":[135],"Elemente":[136],"deren":[139],"Einfluss":[140],"Promoter-Aktivitat":[143],"analysiert.":[144],"gezeigt":[148,319],"werden,":[149,226,320],"Produktion":[154,191,216],"durch":[158,161,195,327,340,353],"Insulin,":[159],"Akt":[164,259,334],"Hemmung":[166],"transkriptionellen":[168],"Aktivitat":[169],"fuhrt,":[172],"stark":[173],"abgeschwacht":[174],"wird.":[175],"Diese":[176],"Daten":[177],"sprechen":[178],"eine":[180,213],"Verknupfung":[181],"Insulinstoffwechsels":[183],"Selenhomoostase":[186,361],"uber":[187,220,260],"Regulation":[189,214,324,337],"Leber.":[197,208],"Versorgung":[199],"Gehirns":[201],"Selen":[203],"erfolgt":[204],"unabhangig":[205,330],"In":[209,238,285],"humanen":[210],"Astrocytomzellen":[211,250],"Phosphoinositid":[222],"3\u00b4-Kinase":[223],"(PI3K)":[224],"festgestellt":[225],"wobei":[227],"Unterschied":[229],"nicht":[233],"beteiligt":[234],"zu":[235,294],"sein":[236],"scheint.":[237],"zudem":[243],"Behandlung":[246],"Hepatom-":[248],"Cu(2+)":[252,278,293,328],"Zn(2+)":[255,280],"PI3K":[261,332],"fuhrt.":[262],"Sowohl":[263],"Kupfer-":[264,359],"Zinkionen":[267],"haben":[268],"insulinmimetische":[270],"Wirkung.":[271],"Entsprechend":[272],"fuhrte":[273,288],"Inkubation":[274,289],"Hepatomzellen":[276,291],"Inaktivierung":[282],"FoxO1a.":[284],"Ubereinstimmung":[286],"damit":[287],"einer":[295],"Abschwachung":[296],"Promoteraktivitaten":[298],"FoxO-Zielgen":[301],"bekannten":[302],"Gens":[303,313],"Glucose":[305],"6-Phosphatase":[306],"hier":[309],"nachgewiesenen":[312],"P.":[316],"diese":[322],"negative":[323],"FoxO-responsiver":[325],"Promotoren":[326],"erfolgt.":[335],"Kupferionen":[341],"Modulation":[344],"Expression":[346],"Selenstoffwechsel":[349],"zentralen":[350],"legen":[355],"Zusammenhang":[357],"nahe.":[362]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
