{"id":"https://openalex.org/W126574499","doi":null,"title":"Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan.","display_name":"Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan.","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W126574499","mag":"126574499","pmid":"https://pubmed.ncbi.nlm.nih.gov/24692744"},"language":"en","primary_location":{"id":"pmid:24692744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24692744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086713851","display_name":"Taichi Isobe","orcid":"https://orcid.org/0000-0001-5686-1940","observed_orcids":["https://orcid.org/0000-0001-5686-1940"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taichi Isobe","raw_affiliation_strings":["Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan. e-baba@c-oncology.med.kyushu-u.ac.jp","Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan. e-baba@c-oncology.med.kyushu-u.ac.jp","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102239805","display_name":"Keita Uchino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018397740","display_name":"National Kyushu Medical Center","ror":"https://ror.org/022296476","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3018397740","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keita Uchino","raw_affiliation_strings":["2Department of Medical Oncology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medical Oncology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan","institution_ids":["https://openalex.org/I3018397740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003587809","display_name":"Chinatsu Makiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chinatsu Makiyama","raw_affiliation_strings":["1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051334674","display_name":"Hiroshi Ariyama","orcid":"https://orcid.org/0000-0002-8374-5045","observed_orcids":["https://orcid.org/0000-0002-8374-5045"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ariyama","raw_affiliation_strings":["1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005510045","display_name":"Shuji Arita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Arita","raw_affiliation_strings":["1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111418737","display_name":"Shingo Tamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Tamura","raw_affiliation_strings":["1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013235151","display_name":"Masato Komoda","orcid":"https://orcid.org/0009-0009-5901-323X","observed_orcids":["https://orcid.org/0009-0009-5901-323X"]},"institutions":[{"id":"https://openalex.org/I3018397740","display_name":"National Kyushu Medical Center","ror":"https://ror.org/022296476","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3018397740","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Komoda","raw_affiliation_strings":["2Department of Medical Oncology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medical Oncology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan","institution_ids":["https://openalex.org/I3018397740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070901487","display_name":"Hitoshi Kusaba","orcid":"https://orcid.org/0000-0002-2949-5970","observed_orcids":["https://orcid.org/0000-0002-2949-5970"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Kusaba","raw_affiliation_strings":["1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061082008","display_name":"Tsuyoshi Shirakawa","orcid":"https://orcid.org/0000-0002-9317-8216","observed_orcids":["https://orcid.org/0000-0002-9317-8216"]},"institutions":[{"id":"https://openalex.org/I4210093709","display_name":"National Hospital Organization Kyushu Cancer Center","ror":"https://ror.org/00mce9b34","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093709","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Shirakawa","raw_affiliation_strings":["3Department of Gastroenterology and Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Gastroenterology and Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210093709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055212193","display_name":"Taito Esaki","orcid":"https://orcid.org/0000-0002-9169-8453","observed_orcids":["https://orcid.org/0000-0002-9169-8453"]},"institutions":[{"id":"https://openalex.org/I4210093709","display_name":"National Hospital Organization Kyushu Cancer Center","ror":"https://ror.org/00mce9b34","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093709","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taito Esaki","raw_affiliation_strings":["3Department of Gastroenterology and Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Gastroenterology and Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210093709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108591661","display_name":"Kenji Mitsugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099698","display_name":"Hamanomachi Hospital","ror":"https://ror.org/015rc4h95","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Mitsugi","raw_affiliation_strings":["4Department of Oncology, Hamanomachi Hospital, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Oncology, Hamanomachi Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210099698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049130190","display_name":"Shigeo Takaishi","orcid":"https://orcid.org/0000-0003-2236-6081","observed_orcids":["https://orcid.org/0000-0003-2236-6081"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4405287010","display_name":"Center for Advanced Medical Innovation, Kyushu University","ror":"https://ror.org/03twn8c58","country_code":"JP","type":"facility","lineage":["https://openalex.org/I135598925","https://openalex.org/I4405287010"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo Takaishi","raw_affiliation_strings":["5Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405287010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102870989","display_name":"Koichi Akashi","orcid":"https://orcid.org/0000-0001-7763-5723","observed_orcids":["https://orcid.org/0000-0001-7763-5723"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Akashi","raw_affiliation_strings":["1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072512404","display_name":"Eishi Baba","orcid":"https://orcid.org/0000-0001-9428-6772","observed_orcids":["https://orcid.org/0000-0001-9428-6772"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eishi Baba","raw_affiliation_strings":["6Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9829,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74672279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"4","first_page":"2035","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6019999980926514},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6940000057220459},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.9129999876022339},{"id":"https://openalex.org/keywords/arterial-thromboembolism","display_name":"arterial thromboembolism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9610000252723694},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9109569787979126},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.837194561958313},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7226419448852539},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6944261193275452},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6842211484909058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6613602638244629},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5257718563079834},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5193694233894348},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.4801351726055145},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47615811228752136},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3509330153465271},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3231130838394165},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24692744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24692744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:126574499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24692744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089857502","https://openalex.org/W4403776709","https://openalex.org/W4389508393","https://openalex.org/W1999129596","https://openalex.org/W2359710392","https://openalex.org/W2075457174","https://openalex.org/W2277547567","https://openalex.org/W2990748392","https://openalex.org/W2590701695","https://openalex.org/W2249224591"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bevacizumab":[1],"(BV)":[2],"is":[3],"widely":[4],"used":[5],"in":[6,86,110],"chemotherapy":[7,35,101],"for":[8,64,142],"metastatic":[9],"colorectal":[10],"cancer":[11],"(mCRC).":[12],"Although":[13],"specific":[14],"adverse":[15,46,66],"events":[16,47,67],"have":[17,23],"been":[18,25],"observed,":[19],"their":[20],"risk":[21,43,62,140],"factors":[22,44,63],"not":[24],"clarified.":[26],"PATIENTS":[27],"AND":[28],"METHODS:":[29],"178":[30,54],"mCRC":[31],"patients":[32,55,115,126],"who":[33],"underwent":[34],"were":[36,48,56,84],"retrospectively":[37],"examined":[38],"and":[39,45,80,82,91,121],"correlations":[40],"between":[41],"possible":[42],"analyzed.":[49],"RESULTS:":[50],"87":[51],"out":[52,112,123],"of":[53,75,93,113,124,145],"treated":[57],"with":[58,97,116,127],"BV-containing":[59],"chemotherapy.":[60],"Possible":[61],"BV-related":[65,143],"were:":[68],"remaining":[69],"primary":[70,118,129],"tumor,":[71],"current":[72],"bleeding,":[73],"history":[74],"arterial":[76],"thromboembolism":[77],"(ATE),":[78],"hypertension,":[79],"proteinuria,":[81],"these":[83],"observed":[85],"22%,":[87],"2%,":[88],"7%,":[89],"16%,":[90],"8%":[92],"patients,":[94],"respectively.":[95],"Patients":[96],"hypertension":[98,105,135],"prior":[99],"to":[100,137],"developed":[102],"significantly":[103],"worse":[104],"(p=0.018).":[106],"Gastrointestinal":[107],"bleeding":[108],"occurred":[109],"3":[111],"18":[114],"residual":[117],"tumor":[119,130],"(16.7%)":[120],"6":[122],"63":[125],"no":[128],"(8.7%)":[131],"(p=0.385).":[132],"CONCLUSION:":[133],"Pre-existing":[134],"appears":[136],"be":[138],"a":[139],"factor":[141],"deterioration":[144],"hypertension.":[146]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}