{"id":"https://openalex.org/W1265713662","doi":"https://doi.org/10.1089/ten.tec.2013.0415","title":"Isolation and Characterization of Alveolar Epithelial Type II Cells Derived from Mouse Embryonic Stem Cells","display_name":"Isolation and Characterization of Alveolar Epithelial Type II Cells Derived from Mouse Embryonic Stem Cells","publication_year":2013,"publication_date":"2013-10-09","ids":{"openalex":"https://openalex.org/W1265713662","doi":"https://doi.org/10.1089/ten.tec.2013.0415","mag":"1265713662","pmid":"https://pubmed.ncbi.nlm.nih.gov/24102479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4026097"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tec.2013.0415","doi":"https://doi.org/10.1089/ten.tec.2013.0415","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tec.2013.0415","pdf_url":null,"source":{"id":"https://openalex.org/S190192123","display_name":"Tissue Engineering Part C Methods","issn_l":"1937-3384","issn":["1937-3384","1937-3392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part C: Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4026097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Huanhuan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huanhuan Sun","raw_affiliation_strings":["Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas","1 Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston , Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas","institution_ids":["https://openalex.org/I4405281163"]},{"raw_affiliation_string":"1 Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston , Houston, Texas","institution_ids":["https://openalex.org/I4405281163"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuan Quan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Quan","raw_affiliation_strings":["Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas","institution_ids":["https://openalex.org/I4405281163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111411955","display_name":"Qing Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Yan","raw_affiliation_strings":["Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas","institution_ids":["https://openalex.org/I4405281163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111411956","display_name":"Xinmiao Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinmiao Peng","raw_affiliation_strings":["Department of Neuroscience, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014058972","display_name":"Zhengmei Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengmei Mao","raw_affiliation_strings":["Microscopy Service Center, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microscopy Service Center, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Texas","institution_ids":["https://openalex.org/I4405281163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091556449","display_name":"Rick A. Wetsel","orcid":"https://orcid.org/0000-0003-4299-5096","observed_orcids":["https://orcid.org/0000-0003-4299-5096"]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick A. Wetsel","raw_affiliation_strings":["Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas","institution_ids":["https://openalex.org/I4405281163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027235813","display_name":"Dachun Wang","orcid":"https://orcid.org/0000-0001-9942-1638","observed_orcids":["https://orcid.org/0000-0001-9942-1638"]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dachun Wang","raw_affiliation_strings":["Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, Houston, Texas","institution_ids":["https://openalex.org/I4405281163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027235813"],"corresponding_institution_ids":["https://openalex.org/I4405281163"],"apc_list":null,"apc_paid":null,"fwci":0.5977,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66188807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"20","issue":"6","first_page":"464","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neomycin-resistance","display_name":"neomycin resistance","score":0.5239999890327454},{"id":"https://openalex.org/keywords/lung-regeneration","display_name":"lung regeneration","score":0.4659999907016754},{"id":"https://openalex.org/keywords/surfactant-proteins","display_name":"surfactant proteins","score":0.7129999995231628},{"id":"https://openalex.org/keywords/air-liquid-interface-culture","display_name":"air-liquid interface culture","score":0.8330000042915344},{"id":"https://openalex.org/keywords/alveolar-epithelial-type-i-cells","display_name":"alveolar epithelial type I cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/knockout-serum-replacement","display_name":"knockout serum replacement","score":0.6269999742507935},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.7508889436721802},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7003965377807617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6879459619522095},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.6667709946632385},{"id":"https://openalex.org/C145156650","wikidata":"https://www.wikidata.org/wiki/Q4253549","display_name":"Lamellar granule","level":3,"score":0.6037721037864685},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5689252614974976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.517577052116394},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47798746824264526},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.43681442737579346},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4242146611213684},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4173828065395355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3482777178287506},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34148406982421875},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3346729278564453},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.29711711406707764},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.2672828435897827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11130473017692566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11064407229423523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06222909688949585},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024861","descriptor_name":"Genetic Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024861","descriptor_name":"Genetic Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024861","descriptor_name":"Genetic Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D061249","descriptor_name":"Batch Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D061249","descriptor_name":"Batch Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D061249","descriptor_name":"Batch Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/ten.tec.2013.0415","doi":"https://doi.org/10.1089/ten.tec.2013.0415","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tec.2013.0415","pdf_url":null,"source":{"id":"https://openalex.org/S190192123","display_name":"Tissue Engineering Part C Methods","issn_l":"1937-3384","issn":["1937-3384","1937-3392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part C: Methods","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3411760","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4026097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4026097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4026097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part C Methods","raw_type":"Text"},{"id":"pmid:24102479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24102479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part C, Methods","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3411760","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4026097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G423342917","display_name":"Therapeutic Potential of Mouse Embryonic Stem Cell Derived Distal Lung Stem Cells","funder_award_id":"R21HL102833","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1517576768","https://openalex.org/W1972662556","https://openalex.org/W1992358636","https://openalex.org/W1993534485","https://openalex.org/W1999242737","https://openalex.org/W2001710027","https://openalex.org/W2013870689","https://openalex.org/W2018809578","https://openalex.org/W2019094071","https://openalex.org/W2023530381","https://openalex.org/W2027246053","https://openalex.org/W2029878978","https://openalex.org/W2033404376","https://openalex.org/W2033926629","https://openalex.org/W2040111843","https://openalex.org/W2048514182","https://openalex.org/W2064496329","https://openalex.org/W2070170734","https://openalex.org/W2070196690","https://openalex.org/W2071142855","https://openalex.org/W2076098479","https://openalex.org/W2078334493","https://openalex.org/W2084276316","https://openalex.org/W2099111992","https://openalex.org/W2104977363","https://openalex.org/W2105902643","https://openalex.org/W2106621292","https://openalex.org/W2107706859","https://openalex.org/W2129118672","https://openalex.org/W2133921544","https://openalex.org/W2136062886","https://openalex.org/W2139373056","https://openalex.org/W2148897157","https://openalex.org/W2157341735","https://openalex.org/W2158078252","https://openalex.org/W2159047813","https://openalex.org/W2171324765","https://openalex.org/W2234034921","https://openalex.org/W2331089332","https://openalex.org/W2417656013"],"related_works":["https://openalex.org/W1974447758","https://openalex.org/W2071142855","https://openalex.org/W2139373056","https://openalex.org/W1992358636","https://openalex.org/W2084276316","https://openalex.org/W2474870364","https://openalex.org/W2810892460","https://openalex.org/W85700997","https://openalex.org/W2130960883","https://openalex.org/W2006541601"],"abstract_inverted_index":{"The":[0,55],"use":[1,56],"of":[2,19,57,74,98,185,319],"embryonic":[3],"stem":[4],"cells":[5,84],"(ESCs)":[6],"to":[7,67,227,247,327],"regenerate":[8],"distal":[9,30],"lung":[10,31,333],"epithelia":[11],"damaged":[12],"by":[13,154],"injuries":[14],"or":[15,62,109],"diseases":[16],"requires":[17],"development":[18],"safe":[20],"and":[21,37,104,196,202,241],"efficient":[22,72],"methodologies":[23],"that":[24,44,141,256,266,306],"direct":[25],"ESC":[26],"differentiation":[27,39,49,73],"into":[28,78,180,296,315],"transplantable":[29],"epithelial":[32,80,298],"progenitors.":[33],"Time-consuming":[34],"culture":[35,170,213],"procedure":[36],"low":[38],"efficiency":[40],"are":[41,45],"major":[42],"problems":[43],"associated":[46],"with":[47,210,234,281],"conventional":[48],"approaches":[50],"via":[51],"embryoid":[52],"body":[53],"formation.":[54],"a":[58,63,95,121,125,181,316,323],"growth":[59],"factor":[60],"cocktail":[61],"lung-specific":[64],"cell-conditioned":[65],"medium":[66,289],"enrich":[68],"definitive":[69],"endoderm":[70],"for":[71,93,100,276],"mouse":[75],"ESCs":[76],"(mESC)":[77],"alveolar":[79,297],"progenitor":[81],"type":[82,299],"II":[83],"(ATIICs)":[85],"has":[86],"been":[87],"reported,":[88],"but":[89],"not":[90,110],"yet":[91],"successful":[92],"generating":[94],"homogenous":[96,182,317],"population":[97,183,318],"ATIICs":[99,113,142,190],"tissue":[101,334],"regeneration":[102],"purpose,":[103],"it":[105],"remains":[106],"unclear":[107],"whether":[108],"those":[111],"mESC-derived":[112,189],"possess":[114],"normal":[115,205,259],"biological":[116],"functions.":[117],"Here,":[118],"we":[119,264],"report":[120],"novel":[122],"method":[123],"using":[124],"genetically":[126,173,308],"modified":[127,174,309],"mESC":[128],"line":[129],"harboring":[130],"an":[131,211],"ATIIC-specific":[132],"neomycin(R)":[133],"transgene":[134],"in":[135,161,215,245,253,258,287,332],"Rosa":[136],"26":[137],"locus.":[138],"We":[139],"showed":[140],"can":[143,176,224,239,270,311],"be":[144,177,225,271,312],"efficiently":[145],"differentiated":[146,179,295,314],"from":[147],"mESCs":[148,175,310],"as":[149,151,204,255],"early":[150],"day":[152],"7":[153],"culturing":[155],"them":[156],"directly":[157],"on":[158,273],"Matrigel-coated":[159,274],"plates":[160,275],"DMEM":[162,288],"containing":[163,290],"15%":[164],"knockout":[165],"serum":[166],"replacement.":[167],"With":[168],"this":[169],"condition,":[171],"the":[172,188,222,267,307],"selectively":[178,313],"(>99%)":[184],"ATIICs.":[186,207,261],"Importantly,":[187],"(mESC-ATIICs)":[191],"exhibited":[192],"typical":[193],"lamellar":[194],"bodies":[195],"expressed":[197],"surfactant":[198,229,243,251],"protein":[199],"A,":[200],"B,":[201],"C":[203],"control":[206,260],"When":[208,285],"cultured":[209,286],"air-liquid-interface":[212],"system":[214],"Small":[216],"Airway":[217],"Epithelial":[218],"Cell":[219],"Growth":[220],"Medium,":[221],"mESC-ATIICs":[223,238,254,269,293],"induced":[226],"secrete":[228,242],"proteins":[230],"after":[231],"being":[232],"treated":[233],"dibutyryl":[235],"cAMP+dexamethasone.":[236],"These":[237],"synthesize":[240],"lipid":[244],"response":[246],"secretagogue,":[248],"demonstrating":[249],"active":[250],"metabolism":[252],"seen":[257],"In":[262],"addition,":[263],"demonstrated":[265],"selected":[268],"maintained":[272],"at":[277],"least":[278],"4":[279],"days":[280],"robust":[282],"proliferative":[283],"capacity.":[284],"10%":[291],"FBS,":[292],"spontaneously":[294],"I":[300],"cells.":[301],"Collectively,":[302],"these":[303],"data":[304],"demonstrate":[305],"functional":[320],"ATIICs,":[321],"providing":[322],"reliable":[324],"cell":[325],"source":[326],"explore":[328],"their":[329],"therapeutic":[330],"potential":[331],"regeneration.":[335]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
