{"id":"https://openalex.org/W126320974","doi":null,"title":"In situ apoptosis assay for the detection of early acute myocardial infarction.","display_name":"In situ apoptosis assay for the detection of early acute myocardial infarction.","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W126320974","mag":"126320974","pmid":"https://pubmed.ncbi.nlm.nih.gov/8780386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865165"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865165","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865165","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046129254","display_name":"Ricardo H. Bardales","orcid":"https://orcid.org/0000-0003-1238-8535","observed_orcids":["https://orcid.org/0000-0003-1238-8535"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R H Bardales","raw_affiliation_strings":["Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L S Hailey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L S Hailey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791258","display_name":"Su Xie","orcid":"https://orcid.org/0000-0002-4942-1581","observed_orcids":["https://orcid.org/0000-0002-4942-1581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020577497","display_name":"Robert F. Schaefer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R F Schaefer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108444666","display_name":"S M Hsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1408,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.96698514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"149","issue":"3","first_page":"821","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.2912999987602234,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cardiac-histopathology","display_name":"cardiac histopathology","score":0.5830000042915344},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7980753779411316},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7212192416191101},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6717677116394043},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.6070802807807922},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6014191508293152},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5997633337974548},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.5359618663787842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5075575113296509},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.49364981055259705},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47489133477211},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.45571067929267883},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.34741559624671936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3366726040840149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30987924337387085},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07778874039649963},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865165","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1865165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:8780386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:126320974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865165","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W94897181","https://openalex.org/W197144613","https://openalex.org/W1495117645","https://openalex.org/W1544768460","https://openalex.org/W1561662137","https://openalex.org/W1974021907","https://openalex.org/W1975896299","https://openalex.org/W1983931044","https://openalex.org/W2008741758","https://openalex.org/W2011903225","https://openalex.org/W2021999082","https://openalex.org/W2038813809","https://openalex.org/W2044333041","https://openalex.org/W2053954735","https://openalex.org/W2058789249","https://openalex.org/W2089843401","https://openalex.org/W2096428903","https://openalex.org/W2101462909","https://openalex.org/W2101698988","https://openalex.org/W2104187725","https://openalex.org/W2116183231","https://openalex.org/W2120751716","https://openalex.org/W2126636055","https://openalex.org/W2138302361","https://openalex.org/W2148219033","https://openalex.org/W2173242103","https://openalex.org/W2184817776","https://openalex.org/W2339182389","https://openalex.org/W4300472050"],"related_works":["https://openalex.org/W2350831455","https://openalex.org/W2314490436","https://openalex.org/W1896255429","https://openalex.org/W7057712390","https://openalex.org/W2045296500","https://openalex.org/W1974613786","https://openalex.org/W7216932751","https://openalex.org/W2362879625","https://openalex.org/W2089625782","https://openalex.org/W1590724445"],"abstract_inverted_index":{"Detection":[0],"and":[1,14,86,120,135,191],"age":[2],"determination":[3,52],"of":[4,21,27,38,53,60,74,80,122,142,156,165,172,211,219,224,240,253],"myocardial":[5,28,143,149],"infarction":[6,103],"(MI)":[7],"is":[8,263,267],"often":[9],"necessary":[10],"in":[11,24,44,124,132,181,231,236,246,250],"both":[12],"clinical":[13],"pathological":[15],"settings.":[16],"Conventional":[17,84],"histopathological":[18],"techniques":[19],"are":[20],"limited":[22],"utility":[23],"the":[25,34,51,72,123,217,260],"demonstration":[26],"ischemic":[29,148],"cell":[30,150],"death":[31],"(MICD)":[32],"within":[33],"first":[35],"6":[36],"hours":[37],"MI.":[39,58],"In":[40,199],"this":[41,200,271],"study,":[42],"an":[43],"situ":[45,125,251],"apoptosis":[46,126,141],"assay":[47,127,252,272],"was":[48,177,234],"evaluated":[49],"for":[50,71,99,128,189,192,214],"early":[54,57,102,278],"MICD":[55,100,129,258,276],"or":[56,101,109,207],"Sections":[59],"formalin-fixed,":[61],"paraffin-embedded":[62],"archival":[63],"tissue":[64],"blocks":[65],"from":[66],"80":[67],"hearts":[68],"were":[69,130,185],"stained":[70],"presence":[73,218],"apoptotic":[75,166,225],"cells":[76,144,167],"by":[77],"specific":[78],"labeling":[79],"nuclear":[81,209],"DNA":[82,254],"fragmentation.":[83],"hematoxylin":[85],"eosin":[87],"stain":[88],"showed":[89,139,205],"acute":[90,157,244],"MI":[91,158,190,245],"(group":[92,104,113,159],"A,":[93,233],"n":[94,106,115],"=":[95,107,116],"32),":[96],"equivocal":[97],"evidence":[98],"B,":[105,183,242],"35),":[108],"no":[110],"abnormal":[111],"findings":[112],"C,":[114],"13).":[117],"The":[118,249],"sensitivity":[119],"specificity":[121],"confirmed":[131],"groups":[133],"A":[134,221],"C":[136],"patients.":[137],"We":[138],"that":[140,229,269],"can":[145,256,274],"occur":[146],"after":[147],"injury.":[151],"Virtually":[152],"all":[153],"documented":[154],"cases":[155,203,238],"A)":[160],"revealed":[161],"a":[162],"sizeable":[163,222],"distribution":[164,223],"visible":[168],"on":[169],"gross":[170],"examination":[171],"glass":[173],"slides.":[174],"Special":[175],"attention":[176],"given":[178],"to":[179,228,281],"patients":[180],"group":[182,232,241],"who":[184],"at":[186],"high":[187],"risk":[188],"suspected":[193],"but":[194],"not":[195],"proved":[196],"cardiac":[197],"death.":[198],"group,":[201],"34/35":[202],"(97%)":[204],"focal":[206],"diffuse":[208],"positivity":[210],"varying":[212],"degrees":[213],"apoptosis,":[215],"confirming":[216],"MICD.":[220],"cells,":[226],"similar":[227],"observed":[230],"noted":[235],"13/35":[237],"(37%)":[239],"suggesting":[243],"these":[247],"cases.":[248],"fragmentation":[255],"detect":[257,275],"while":[259],"histological":[261],"diagnosis":[262],"still":[264],"inconclusive.":[265],"It":[266],"estimated":[268],"with":[270],"one":[273],"as":[277,279],"2":[280],"4":[282],"hours.":[283]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
