{"id":"https://openalex.org/W126307397","doi":null,"title":"Molecular genetics and mechanisms of pigmentation and melanoma","display_name":"Molecular genetics and mechanisms of pigmentation and melanoma","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W126307397","mag":"126307397"},"language":"en","primary_location":{"id":"pmh:oai:pub.epsilon.slu.se:2409","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/2409/1/sundstrom_e_101117.pdf","pdf_url":"https://pub.epsilon.slu.se/2409/1/sundstrom_e_101117.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pub.epsilon.slu.se/2409/1/sundstrom_e_101117.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015878392","display_name":"Elisabeth Sundstr\u00f6m","orcid":"https://orcid.org/0000-0001-9526-8541","observed_orcids":["https://orcid.org/0000-0001-9526-8541"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elisabeth Sundstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9526-8541","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015878392"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pigmentation","display_name":"pigmentation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/grey-horses","display_name":"grey horses","score":0.609000027179718},{"id":"https://openalex.org/keywords/stx17","display_name":"STX17","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cdkn2a-b","display_name":"CDKN2A/B","score":0.8140000104904175},{"id":"https://openalex.org/keywords/domestic-animals","display_name":"domestic animals","score":0.5419999957084656},{"id":"https://openalex.org/keywords/selective-breeding","display_name":"selective breeding","score":0.6700000166893005},{"id":"https://openalex.org/keywords/vitiligo-like-depigmentation","display_name":"vitiligo-like depigmentation","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2776972258","wikidata":"https://www.wikidata.org/wiki/Q3705665","display_name":"Depigmentation","level":2,"score":0.7238128781318665},{"id":"https://openalex.org/C127745971","wikidata":"https://www.wikidata.org/wiki/Q81025","display_name":"Feather","level":2,"score":0.7129169702529907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.679184079170227},{"id":"https://openalex.org/C134387633","wikidata":"https://www.wikidata.org/wiki/Q11395","display_name":"Domestication","level":2,"score":0.6447101831436157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5632923245429993},{"id":"https://openalex.org/C56273599","wikidata":"https://www.wikidata.org/wiki/Q3122841","display_name":"White (mutation)","level":3,"score":0.5278432369232178},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5158088207244873},{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.418677419424057},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4120391011238098},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3929772973060608},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14194786548614502}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pub.epsilon.slu.se:2409","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/2409/1/sundstrom_e_101117.pdf","pdf_url":"https://pub.epsilon.slu.se/2409/1/sundstrom_e_101117.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:126307397","doi":null,"is_oa":false,"landing_page_url":"https://pub.epsilon.slu.se/2409/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pub.epsilon.slu.se:2409","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/2409/1/sundstrom_e_101117.pdf","pdf_url":"https://pub.epsilon.slu.se/2409/1/sundstrom_e_101117.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W126307397.pdf","grobid_xml":"https://content.openalex.org/works/W126307397.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W20333627","https://openalex.org/W119201813","https://openalex.org/W130949177","https://openalex.org/W150415700","https://openalex.org/W426344629","https://openalex.org/W650973427","https://openalex.org/W1163076423","https://openalex.org/W1500051024","https://openalex.org/W1565041471","https://openalex.org/W1775187111","https://openalex.org/W1903683036","https://openalex.org/W1968779006","https://openalex.org/W1970625220","https://openalex.org/W1971050728","https://openalex.org/W1971093804","https://openalex.org/W1971512164","https://openalex.org/W1973947033","https://openalex.org/W1976384461","https://openalex.org/W1978385232","https://openalex.org/W1980073547","https://openalex.org/W1982527304","https://openalex.org/W1984948591","https://openalex.org/W1985910684","https://openalex.org/W1986909856","https://openalex.org/W1988241422","https://openalex.org/W1989180038","https://openalex.org/W1990005278","https://openalex.org/W1999634133","https://openalex.org/W2003525320","https://openalex.org/W2004426310","https://openalex.org/W2006809167","https://openalex.org/W2013204606","https://openalex.org/W2017478542","https://openalex.org/W2018365560","https://openalex.org/W2027810940","https://openalex.org/W2029795905","https://openalex.org/W2031111848","https://openalex.org/W2032579724","https://openalex.org/W2032631425","https://openalex.org/W2037699262","https://openalex.org/W2041578893","https://openalex.org/W2043584813","https://openalex.org/W2049092298","https://openalex.org/W2049989672","https://openalex.org/W2055994735","https://openalex.org/W2056495027","https://openalex.org/W2057298564","https://openalex.org/W2059660113","https://openalex.org/W2060600354","https://openalex.org/W2064497209","https://openalex.org/W2072656506","https://openalex.org/W2077363675","https://openalex.org/W2081527131","https://openalex.org/W2084312697","https://openalex.org/W2084891010","https://openalex.org/W2085154635","https://openalex.org/W2085270765","https://openalex.org/W2086732047","https://openalex.org/W2092087055","https://openalex.org/W2097504051","https://openalex.org/W2097794242","https://openalex.org/W2099888765","https://openalex.org/W2108615157","https://openalex.org/W2115693635","https://openalex.org/W2117746282","https://openalex.org/W2119095224","https://openalex.org/W2122889044","https://openalex.org/W2123393607","https://openalex.org/W2124362171","https://openalex.org/W2127086861","https://openalex.org/W2127325369","https://openalex.org/W2130987003","https://openalex.org/W2133877529","https://openalex.org/W2135223838","https://openalex.org/W2141456229","https://openalex.org/W2163188200","https://openalex.org/W2164714646","https://openalex.org/W2167526319","https://openalex.org/W2279275424","https://openalex.org/W2284752289","https://openalex.org/W2313525957","https://openalex.org/W2416862536","https://openalex.org/W2799639628","https://openalex.org/W4247906151","https://openalex.org/W4298388662"],"related_works":["https://openalex.org/W2057505444","https://openalex.org/W2054022987","https://openalex.org/W2956969355","https://openalex.org/W2123570137","https://openalex.org/W2064497209","https://openalex.org/W4401989219","https://openalex.org/W4393430188","https://openalex.org/W2058521575","https://openalex.org/W2134475351","https://openalex.org/W183606139"],"abstract_inverted_index":{"Ever":[0],"since":[1],"man":[2],"domesticated":[3],"the":[4,65,80,91,95,101,124,134,137,182,195,199,212,221,236,268,285,319,336,355],"first":[5],"wild":[6],"animals":[7],"several":[8],"thousand":[9],"years":[10,164],"ago,":[11],"many":[12,190],"species":[13,51],"have":[14,39,53,104,165],"been":[15,62,105,209],"living":[16],"in":[17,74,88,100,172,225,257,267,287,294,354],"close":[18],"relationship":[19],"with":[20,84,253,346],"humans,":[21],"being":[22],"objects":[23],"for":[24],"our":[25],"requests":[26],"and":[27,71,86,90,119,136,144,152,178,198,243,255,297,351],"wishes":[28],"about":[29],"any":[30,111],"kind":[31],"of":[32,47,58,126,158,215,323,349,358],"phenotypic":[33],"traits.":[34],"As":[35],"a":[36,44,229,262,301,309,341],"result,":[37],"we":[38,52],"by":[40,123,176],"selective":[41],"breeding":[42],"created":[43],"fascinating":[45],"spectrum":[46],"phenotypes":[48,73],"within":[49],"most":[50],"domesticated.":[54],"The":[55,129,168,202,249,326],"broad":[56],"aim":[57],"this":[59,234],"thesis":[60],"has":[61,207,289],"to":[63,94,211,275,329,335],"investigate":[64],"molecular":[66,321,356],"mechanisms":[67,357],"causing":[68,82,204,238,251],"different":[69],"colour":[70],"pattern":[72,99,171],"domestic":[75,102],"animals.":[76],"In":[77,233],"more":[78],"detail,":[79],"mutation":[81,203,250,286],"Greying":[83,252],"age":[85,125,254],"melanoma":[87,256,295,324,350],"horses":[89,108,160,258],"mutations":[92,237,327],"leading":[93],"Sex-linked":[96,169,205,330],"barring":[97,170,185,206,231,331],"feather":[98],"chicken":[103],"studied.":[106],"Grey":[107,150,159],"are":[109,187,241,247],"born":[110],"colour,":[112],"but":[113],"gradually":[114],"loose":[115],"their":[116,244],"hair":[117],"pigmentation":[118,130,276,359],"usually":[120],"become":[121],"white":[122,179],"6-8":[127],"years.":[128],"loss":[131],"only":[132],"affects":[133],"hair,":[135],"skin":[138],"stays":[139],"dark":[140],"throughout":[141],"life.":[142],"Melanomas":[143],"vitiligo-like":[145],"depigmentation":[146],"frequently":[147],"occur":[148],"among":[149,189],"horses,":[151],"it":[153,280,299],"is":[154,174],"claimed":[155],"that":[156,284,298],"70-80%":[157],"older":[161],"than":[162],"15":[163],"melanocytic":[166],"lesions.":[167],"chickens":[173],"characterized":[175],"black":[177],"stripes":[180],"on":[181,318],"feathers.":[183],"Similar":[184],"patterns":[186],"found":[188],"bird":[191],"species,":[192],"such":[193],"as":[194,261],"peregrine":[196],"falcon":[197],"zebra":[200],"finch.":[201],"previously":[208,272],"mapped":[210,334],"q":[213],"arm":[214],"chromosome":[216],"Z,":[217],"which":[218],"explains":[219],"why":[220],"homogametic":[222],"(ZZ)":[223],"sex":[224],"chickens,":[226],"males,":[227],"develop":[228],"broader":[230],"pattern.":[232],"thesis,":[235],"both":[239],"traits":[240],"identified,":[242],"functional":[245],"properties":[246],"investigated.":[248],"was":[259],"identified":[260],"4.6":[263],"kb":[264],"intronic":[265],"duplication":[266],"gene":[269],"STX17,":[270],"not":[271],"linked":[273,328],"either":[274],"or":[277],"melanoma.":[278],"Moreover,":[279],"could":[281,332],"be":[282,333],"shown":[283],"STX17":[288],"an":[290],"elevated":[291],"copy":[292],"number":[293],"DNA,":[296],"contains":[300],"strong":[302],"melanocyte":[303],"specific":[304],"activating":[305],"regulatory":[306],"element":[307],"residing":[308],"MITF":[310],"binding":[311],"site.":[312],"This":[313],"finding":[314],"sheds":[315],"further":[316],"light":[317],"intriguing":[320],"processes":[322],"development.":[325],"CDKN2A/B":[337],"tumour":[338],"suppressor":[339],"locus,":[340],"genetic":[342],"region":[343],"commonly":[344],"associated":[345],"familiar":[347],"forms":[348],"also":[352],"implied":[353],"regulation.":[360]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}