{"id":"https://openalex.org/W126139956","doi":null,"title":"Phorbol ester regulation of Ca2+ flux during natural, lectin and antibody-dependent killing.","display_name":"Phorbol ester regulation of Ca2+ flux during natural, lectin and antibody-dependent killing.","publication_year":1986,"publication_date":"1986-11-01","ids":{"openalex":"https://openalex.org/W126139956","mag":"126139956","pmid":"https://pubmed.ncbi.nlm.nih.gov/3793135","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453190"},"language":"en","primary_location":{"id":"pmid:3793135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3793135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453190/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049241081","display_name":"Mikael Jondal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Jondal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Ng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042652382","display_name":"Manuel Elkin Patarroyo","orcid":"https://orcid.org/0000-0002-1119-6040","observed_orcids":["https://orcid.org/0000-0002-1119-6040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Patarroyo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112043230","display_name":"Per Anders Broliden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Broliden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1485,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77048291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"3","first_page":"347","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.9419999718666077},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9330000281333923},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.6029999852180481},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.8930000066757202},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.9319999814033508},{"id":"https://openalex.org/keywords/calcium-flux","display_name":"calcium flux","score":0.7039999961853027},{"id":"https://openalex.org/keywords/retinal","display_name":"retinal","score":0.5450000166893005},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9850000143051147},{"id":"https://openalex.org/keywords/clomiphene","display_name":"clomiphene citrate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inositol-phospholipid-hydrolysis","display_name":"inositol phospholipid hydrolysis","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.7435422539710999},{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.55989009141922},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.539476752281189},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5372936725616455},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5166435837745667},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5046802759170532},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.44226595759391785},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4336678087711334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3994165062904358},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3751820921897888},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3703092336654663},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1062069833278656},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002996","descriptor_name":"Clomiphene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012172","descriptor_name":"Retinaldehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:3793135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3793135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1453190","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453190/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:126139956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3793135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453190","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453190/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W155457214","https://openalex.org/W218461449","https://openalex.org/W1492900516","https://openalex.org/W1517764404","https://openalex.org/W1557498748","https://openalex.org/W1563911210","https://openalex.org/W1572747961","https://openalex.org/W1649879758","https://openalex.org/W1964075877","https://openalex.org/W1970730569","https://openalex.org/W1973193588","https://openalex.org/W1977731416","https://openalex.org/W1979428583","https://openalex.org/W1981070246","https://openalex.org/W1982518867","https://openalex.org/W1994722790","https://openalex.org/W2001692359","https://openalex.org/W2006194428","https://openalex.org/W2026108503","https://openalex.org/W2031453105","https://openalex.org/W2048375356","https://openalex.org/W2079227015","https://openalex.org/W2149921595","https://openalex.org/W2414229429"],"related_works":["https://openalex.org/W2050607077","https://openalex.org/W1825763428","https://openalex.org/W2053073742","https://openalex.org/W2073432676","https://openalex.org/W1499361606","https://openalex.org/W1786972795","https://openalex.org/W1973005880","https://openalex.org/W1965761745","https://openalex.org/W2141206772","https://openalex.org/W2025289279"],"abstract_inverted_index":{"Phorbol":[0],"ester":[1],"12-O-tetradecanoylphorbol-13-acetate":[2],"(TPA),":[3],"an":[4],"activator":[5],"of":[6,28,30,49,57,88,114,150,169,176,189,196],"protein":[7,80,101,151,170],"kinase":[8,81,102,152,171],"C,":[9,82],"suppresses":[10],"natural,":[11],"lectin":[12],"and":[13,41,75,95,109,126],"antibody-dependent":[14,107],"killing":[15,29,56,90,108,144,163],"by":[16,46,61,164],"normal":[17],"human":[18],"lymphocytes":[19],"in":[20,181],"short-term":[21],"radioisotope":[22],"release":[23],"assays.":[24],"Fifty":[25],"percent":[26],"inhibition":[27,42,87],"lymphoid":[31],"target":[32],"cells":[33,60,64],"was":[34,43,120,129],"seen":[35],"at":[36,91,131],"approximately":[37],"5":[38],"ng/ml":[39],"TPA":[40,54,132,160],"further":[44],"potentiated":[45],"the":[47,117,174,187],"presence":[48],"monocytic":[50],"cells.":[51],"In":[52],"contrast,":[53],"increased":[55],"K-562":[58],"erythroleukaemic":[59],"non-adherent":[62],"NK":[63,89],"with":[65,155],"optimal":[66],"activity":[67],"around":[68],"1":[69],"ng/ml.":[70],"Two":[71],"anti-estrogenic":[72],"drugs,":[73],"tamoxifen":[74],"clomiphene,":[76],"known":[77],"to":[78,85,135],"inhibit":[79],"gave":[83],"near":[84],"complete":[86],"concentrations":[92,133],"12":[93],"microM":[94],"30":[96],"microM,":[97],"respectively.":[98],"Retinal,":[99],"another":[100],"C":[103,153,172],"inhibitor,":[104],"inhibited":[105],"both":[106],"lectin-dependent":[110],"killing.":[111,139],"An":[112],"influx":[113],"45Ca2+":[115],"into":[116],"effector":[118],"population":[119],"found":[121],"during":[122],"effector-target":[123],"cell":[124,190],"conjugation":[125],"this":[127],"flux":[128],"suppressed":[130,138],"similar":[134],"those":[136],"that":[137,143],"The":[140],"results":[141],"suggest":[142],"depends":[145],"on":[146,173],"a":[147,156,165],"co-ordinated":[148],"activation":[149],"together":[154],"channel-dependent":[157],"calcium":[158],"influx.":[159],"may":[161],"suppress":[162],"negative":[166],"feedback":[167],"effect":[168],"hydrolysis":[175],"inositol":[177],"phospholipids,":[178],"as":[179],"demonstrated":[180],"many":[182],"other":[183],"systems,":[184],"or":[185],"through":[186],"down-regulation":[188],"surface":[191],"receptors":[192],"required":[193],"for":[194],"triggering":[195],"lysis.":[197]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}