{"id":"https://openalex.org/W126085503","doi":null,"title":"Down-regulation of DNA Methyltransferase 1 by Peroxisome Proliferator-Activated Receptor Gamma in Hepatic Stellate Cells","display_name":"Down-regulation of DNA Methyltransferase 1 by Peroxisome Proliferator-Activated Receptor Gamma in Hepatic Stellate Cells","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W126085503","mag":"126085503"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:13164","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/13164/1/jilong-thesis.pdf","pdf_url":"http://d-scholarship.pitt.edu/13164/1/jilong-thesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/13164/1/jilong-thesis.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100624848","display_name":"Jilong Li","orcid":"https://orcid.org/0000-0002-9864-4650","observed_orcids":["https://orcid.org/0000-0002-9864-4650"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jilong Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9864-4650","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100624848"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.27639999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9459999799728394},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.95721435546875},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.6791096925735474},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.6266979575157166},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6098182797431946},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5421472787857056},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5393625497817993},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.501840353012085},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4631955027580261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45164769887924194},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4437353014945984},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.44318220019340515},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4338610768318176},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4291917383670807},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4209291934967041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41219693422317505},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3971947133541107},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37964698672294617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36576083302497864},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3354031443595886},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.31242287158966064},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29186272621154785},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.19245335459709167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16238093376159668},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14433306455612183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11841228604316711},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10917580127716064}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:13164","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/13164/1/jilong-thesis.pdf","pdf_url":"http://d-scholarship.pitt.edu/13164/1/jilong-thesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:126085503","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/13164/1/jilong%2Dthesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:13164","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/13164/1/jilong-thesis.pdf","pdf_url":"http://d-scholarship.pitt.edu/13164/1/jilong-thesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W126085503.pdf","grobid_xml":"https://content.openalex.org/works/W126085503.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1489551155","https://openalex.org/W1492606093","https://openalex.org/W1493842788","https://openalex.org/W1511537290","https://openalex.org/W1516756689","https://openalex.org/W1544893850","https://openalex.org/W1603866234","https://openalex.org/W1606335631","https://openalex.org/W1812573520","https://openalex.org/W1966064283","https://openalex.org/W1969462345","https://openalex.org/W1975843538","https://openalex.org/W1989068609","https://openalex.org/W1992006494","https://openalex.org/W1997474235","https://openalex.org/W2002322555","https://openalex.org/W2005025375","https://openalex.org/W2014113220","https://openalex.org/W2018458158","https://openalex.org/W2025294090","https://openalex.org/W2025657436","https://openalex.org/W2026160870","https://openalex.org/W2032566922","https://openalex.org/W2032743024","https://openalex.org/W2037733084","https://openalex.org/W2041587548","https://openalex.org/W2047591801","https://openalex.org/W2048430659","https://openalex.org/W2050717908","https://openalex.org/W2052814004","https://openalex.org/W2053213384","https://openalex.org/W2055628636","https://openalex.org/W2056521900","https://openalex.org/W2056927568","https://openalex.org/W2059099579","https://openalex.org/W2063369009","https://openalex.org/W2066655008","https://openalex.org/W2071298219","https://openalex.org/W2072234373","https://openalex.org/W2075671160","https://openalex.org/W2079080809","https://openalex.org/W2089076289","https://openalex.org/W2090559269","https://openalex.org/W2090796152","https://openalex.org/W2091296342","https://openalex.org/W2091334048","https://openalex.org/W2111288662","https://openalex.org/W2111525805","https://openalex.org/W2114599216","https://openalex.org/W2115133553","https://openalex.org/W2118820170","https://openalex.org/W2118881723","https://openalex.org/W2120335459","https://openalex.org/W2122530058","https://openalex.org/W2124334318","https://openalex.org/W2130822427","https://openalex.org/W2131655174","https://openalex.org/W2131891237","https://openalex.org/W2132486302","https://openalex.org/W2135134693","https://openalex.org/W2135925928","https://openalex.org/W2137367647","https://openalex.org/W2138513279","https://openalex.org/W2138934663","https://openalex.org/W2142988890","https://openalex.org/W2149139187","https://openalex.org/W2151898526","https://openalex.org/W2159719851","https://openalex.org/W2163207725","https://openalex.org/W2165062244","https://openalex.org/W2167158568","https://openalex.org/W2171533490","https://openalex.org/W2292773623","https://openalex.org/W2604337567","https://openalex.org/W7098958697"],"related_works":["https://openalex.org/W2092088876","https://openalex.org/W2091296342","https://openalex.org/W2050805873","https://openalex.org/W2051923547","https://openalex.org/W2084096026","https://openalex.org/W7014354272","https://openalex.org/W2159202892","https://openalex.org/W2883915715","https://openalex.org/W2802381256","https://openalex.org/W7099750770"],"abstract_inverted_index":{"DNA":[0,16,28],"methyltransferase":[1],"(DNMT)":[2],"1":[3],"is":[4,9],"a":[5,31,43,56,175],"critical":[6],"enzyme":[7],"which":[8,54,150],"mainly":[10],"responsible":[11],"for":[12],"conversion":[13],"of":[14,46,59,67,80,93,99,104,112,123,128,141,184],"unmethylated":[15],"into":[17],"hemimethylated":[18],"DNA.":[19],"Previous":[20],"studies":[21,169],"have":[22],"suggested":[23],"that":[24,120,152,171],"enzymes":[25],"related":[26],"to":[27,77],"methylation":[29],"play":[30,174],"very":[32],"important":[33,110],"role":[34,111,176],"in":[35,48,61,73,114,177],"liver":[36],"fibrosis.":[37],"In":[38],"this":[39],"study,":[40],"we":[41],"identified":[42],"significant":[44],"over-expression":[45],"DNMT1":[47,60,81,94,131,155,165],"activated":[49,74],"hepatic":[50],"stellate":[51],"cells":[52],"(HSCs),":[53],"suggests":[55],"vital":[57],"function":[58],"HSCs":[62,75,179],"transactivation.":[63,116],"Interestingly,":[64],"ligand":[65,86,121],"activation":[66,122,127],"peroxisome":[68],"proliferator-activated":[69],"receptor":[70],"gamma":[71],"(PPAR-\u03b3)":[72],"led":[76],"efficient":[78],"down-regulation":[79],"expression.":[82],"Furthermore,":[83],"the":[84,91,97,102,129],"PPAR-\u03b3":[85,100,113,124,153,172],"rosiglitazone":[87],"(RSG)":[88],"dramatically":[89],"down-regulated":[90],"expression":[92,98,145,156,183],"and":[95,134,148],"up-regulated":[96],"during":[101],"transactivation":[103,180],"primary":[105],"rat":[106],"HSCs,":[107],"suggesting":[108],"an":[109],"HSC":[115],"Reporter":[117],"assays":[118],"showed":[119],"inhibited":[125],"transcriptional":[126],"human":[130],"gene":[132],"promoter":[133],"such":[135],"inhibition":[136],"was":[137],"rescued":[138],"by":[139,181],"transfection":[140],"nuclear":[142],"factor-kappaB":[143],"(NF-\u03baB)":[144],"vector":[146],"pCMV-p50":[147],"pCMV-p65,":[149],"indicates":[151],"suppress":[154],"via":[157],"negatively":[158],"interfering":[159],"with":[160],"NF-\u03baB":[161],"binding":[162],"activity":[163],"on":[164],"promoter.":[166],"Conclusion:":[167],"These":[168],"suggest":[170],"may":[173],"inhibiting":[178],"suppressing":[182],"DNMT1.":[185]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}