{"id":"https://openalex.org/W126059566","doi":"https://doi.org/10.1152/ajpheart.1996.271.5.h2014","title":"Computational simulations of local vascular heparin deposition and distribution","display_name":"Computational simulations of local vascular heparin deposition and distribution","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W126059566","doi":"https://doi.org/10.1152/ajpheart.1996.271.5.h2014","mag":"126059566","pmid":"https://pubmed.ncbi.nlm.nih.gov/8945921"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1996.271.5.h2014","doi":"https://doi.org/10.1152/ajpheart.1996.271.5.h2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1996.271.5.h2014","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038170950","display_name":"Mark A. Lovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Lovich","raw_affiliation_strings":["Division of Health Sciences and Technology, Harvard University-Massachusetts Institute of Technology, Cambridge 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Health Sciences and Technology, Harvard University-Massachusetts Institute of Technology, Cambridge 02139, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210092658","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005931821","display_name":"Elazer Reuven Edelman","orcid":"https://orcid.org/0000-0002-7832-7156","observed_orcids":["https://orcid.org/0000-0002-7832-7156"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. R. Edelman","raw_affiliation_strings":["Division of Health Sciences and Technology, HarvardUniversity-Massachusetts Institute of Technology, Cambridge 02139,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Health Sciences and Technology, HarvardUniversity-Massachusetts Institute of Technology, Cambridge 02139,USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210092658","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9757,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.81287356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"271","issue":"5","first_page":"H2014","last_page":"H2024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5752000212669373,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5752000212669373,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.09759999811649323,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/drug-deposition","display_name":"drug deposition","score":0.6299999952316284},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.7490000128746033},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.703406035900116},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6860819458961487},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6186188459396362},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5956404805183411},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5633265972137451},{"id":"https://openalex.org/C64297162","wikidata":"https://www.wikidata.org/wiki/Q1987070","display_name":"Deposition (geology)","level":3,"score":0.545111894607544},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5362251400947571},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.47482356429100037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42831701040267944},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.36545246839523315},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36014944314956665},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29573458433151245},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27393823862075806},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2625117599964142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15508496761322021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15138176083564758},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12756523489952087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0806158185005188},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2816523","wikidata":"https://www.wikidata.org/wiki/Q180184","display_name":"Sediment","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020136","descriptor_name":"Hydrogel, Polyethylene Glycol Dimethacrylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1996.271.5.h2014","doi":"https://doi.org/10.1152/ajpheart.1996.271.5.h2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1996.271.5.h2014","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:8945921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8945921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G444125866","display_name":null,"funder_award_id":"GM/HL49039","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W61761228","https://openalex.org/W2255026455","https://openalex.org/W2128842001","https://openalex.org/W2030809073","https://openalex.org/W1992764266","https://openalex.org/W2087441280","https://openalex.org/W2008561295","https://openalex.org/W2023893109","https://openalex.org/W2162581965","https://openalex.org/W4299952154"],"abstract_inverted_index":{"Local":[0],"vascular":[1,33,84],"drug":[2,47,79,111,159,168,178],"delivery":[3],"systems":[4,38,90],"provide":[5],"elevated":[6],"concentrations":[7],"in":[8,31,83,114,213],"target":[9],"arterial":[10,45],"tissues":[11,85],"while":[12],"minimizing":[13],"systemic":[14],"side":[15],"effects;":[16],"however,":[17],"definition":[18],"of":[19,36,78,98,109,124,128,131,156,193],"their":[20],"precise":[21],"pharmacokinetics":[22],"remains":[23],"elusive.":[24],"The":[25,171,209],"standard":[26],"labeled":[27,132],"tracer":[28],"assays":[29],"used":[30,212,230],"experimental":[32,140],"pharmacokinetic":[34],"studies":[35],"these":[37,89,214],"are":[39,216],"limited":[40],"because":[41],"they":[42],"quantify":[43],"the":[44,61,110,119,129,154,157,205,220,233],"average":[46],"concentration":[48,53],"as":[49],"opposed":[50],"to":[51,59,152,204,231],"transmural":[52],"profiles,":[54],"require":[55],"many":[56],"animal":[57],"experiments":[58],"elucidate":[60],"time-varying":[62],"deposition,":[63],"and":[64,81,160,166,218,225,239],"track":[65],"label":[66],"rather":[67],"than":[68],"intact":[69],"biologically":[70,176],"active":[71],"drug.":[72],"In":[73],"this":[74],"study,":[75],"computational":[76],"simulations":[77,97,143,192,215],"deposition":[80],"distribution":[82,226],"after":[86],"release":[87],"from":[88,163,179],"have":[91,188],"provided":[92,145],"two":[93],"important":[94],"insights.":[95],"First,":[96],"arteries":[99],"that":[100,107,144,200],"were":[101],"uniformly":[102],"loaded":[103],"with":[104,142,219],"heparin":[105],"predicted":[106],"most":[108],"is":[112],"cleared":[113],"<":[115],"1":[116],"h,":[117],"illustrating":[118],"need":[120],"for":[121],"sustained":[122],"modes":[123],"delivery.":[125],"Second,":[126],"some":[127],"limitations":[130],"tracers":[133],"can":[134,173,228],"be":[135,229],"over":[136],"come":[137],"by":[138],"combining":[139],"data":[141],"high":[146],"spatial":[147],"resolution.":[148],"This":[149],"enabled":[150],"us":[151],"describe":[153],"kinetics":[155],"deposited":[158],"distinguish":[161],"soluble":[162],"reversibly":[164],"bound":[165],"internalized":[167],"within":[169],"cells.":[170],"latter":[172],"help":[174],"differentiate":[175],"viable":[177],"its":[180],"committed":[181],"inactive":[182],"form":[183],"or":[184],"metabolites.":[185],"These":[186],"points":[187],"been":[189,202],"illustrated":[190],"through":[191],"a":[194],"novel":[195],"endovascular":[196],"hydrogel":[197],"heparin-delivery":[198],"system":[199],"has":[201],"applied":[203],"porcine":[206],"coronary":[207],"artery.":[208],"basic":[210],"models":[211],"generalized,":[217],"appropriate":[221],"boundary":[222],"conditions,":[223],"binding":[224],"constants":[227],"study":[232],"physical":[234],"interactions":[235],"between":[236],"any":[237],"compound":[238],"tissue.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}