{"id":"https://openalex.org/W12569229","doi":"https://doi.org/10.1055/s-0038-1650549","title":"Association between High Values of D-dimer and Tissue-plasminogen Activator Activity and First Gastrointestinal Bleeding in Cirrhotic Patients","display_name":"Association between High Values of D-dimer and Tissue-plasminogen Activator Activity and First Gastrointestinal Bleeding in Cirrhotic Patients","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W12569229","doi":"https://doi.org/10.1055/s-0038-1650549","mag":"12569229","pmid":"https://pubmed.ncbi.nlm.nih.gov/8865526"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1650549","doi":"https://doi.org/10.1055/s-0038-1650549","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1650549","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076547685","display_name":"Francesco Violi","orcid":"https://orcid.org/0000-0002-6610-7068","observed_orcids":["https://orcid.org/0000-0002-6610-7068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Violi","raw_affiliation_strings":["The Istituto di I Clinica Medica, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Istituto di I Clinica Medica, Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047687063","display_name":"Stefania Basili","orcid":"https://orcid.org/0000-0002-6987-1926","observed_orcids":["https://orcid.org/0000-0002-6987-1926"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Basili","raw_affiliation_strings":["Istituto Terapia Medica, Universit\u00e0 \u201cLa Sapienza\u201d, Policlinico Umberto L, Roma, Italy","Internal Medicine and Medical Specialties"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Terapia Medica, Universit\u00e0 \u201cLa Sapienza\u201d, Policlinico Umberto L, Roma, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Internal Medicine and Medical Specialties","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028571377","display_name":"Domenico Ferro","orcid":"https://orcid.org/0000-0001-5222-4477","observed_orcids":["https://orcid.org/0000-0001-5222-4477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Domenico Ferro","raw_affiliation_strings":["The Istituto di I Clinica Medica, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Istituto di I Clinica Medica, Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035396180","display_name":"Claudio Quintarelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio Quintarelli","raw_affiliation_strings":["The Istituto di I Clinica Medica, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Istituto di I Clinica Medica, Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103524102","display_name":"Cesare Alessandri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cesare Alessandri","raw_affiliation_strings":["The Istituto di I Clinica Medica, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Istituto di I Clinica Medica, Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113927893","display_name":"Corrado Cordova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Corrado Cordova","raw_affiliation_strings":["Istituto Terapia Medica, Universit\u00e0 \u201cLa Sapienza\u201d, Policlinico Umberto L, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Terapia Medica, Universit\u00e0 \u201cLa Sapienza\u201d, Policlinico Umberto L, Roma, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":null,"display_name":"CALC Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CALC Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9476,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.85527167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"76","issue":"02","first_page":"177","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperfibrinolysis","display_name":"hyperfibrinolysis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.7960000038146973},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/esophageal-varices","display_name":"esophageal varices","score":0.949999988079071},{"id":"https://openalex.org/keywords/bleeding-risk-prediction","display_name":"bleeding risk prediction","score":0.7129999995231628},{"id":"https://openalex.org/keywords/fibrin-degradation-products","display_name":"fibrin degradation products","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.6340000033378601},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2781219028","wikidata":"https://www.wikidata.org/wiki/Q5957994","display_name":"Hyperfibrinolysis","level":3,"score":0.9681949615478516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8276157379150391},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7027273178100586},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6655784845352173},{"id":"https://openalex.org/C2779519742","wikidata":"https://www.wikidata.org/wiki/Q198526","display_name":"D-dimer","level":2,"score":0.6183796525001526},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6119677424430847},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.584792971611023},{"id":"https://openalex.org/C2778012290","wikidata":"https://www.wikidata.org/wiki/Q2624485","display_name":"Varices","level":3,"score":0.5514798164367676},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.5354832410812378},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.43015390634536743},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.41404205560684204}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000933","descriptor_name":"Antifibrinolytic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010960","descriptor_name":"Plasminogen Activators","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017093","descriptor_name":"Liver Failure","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017093","descriptor_name":"Liver Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0038-1650549","doi":"https://doi.org/10.1055/s-0038-1650549","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1650549","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:8865526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8865526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/41620","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1996VD26000011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4250671816","https://openalex.org/W1998739205","https://openalex.org/W2185594452","https://openalex.org/W206572528","https://openalex.org/W2323077648","https://openalex.org/W2357538564","https://openalex.org/W2374109342","https://openalex.org/W4401824505","https://openalex.org/W2057622480","https://openalex.org/W1993575120"],"abstract_inverted_index":{"Cirrhotic":[0],"patients":[1,50,90,125,161],"with":[2,51,116],"decompensated":[3],"state":[4],"and":[5,32,42,54,62,82,101,107,119],"high":[6,15,78],"serum":[7],"levels":[8],"of":[9,17,21,40,80,110,139,164],"fibrin(ogen)":[10],"degradation":[11],"products":[12],"are":[13],"at":[14,162],"risk":[16,163],"bleeding.":[18,165],"The":[19],"aim":[20],"this":[22],"study":[23,61],"was":[24],"to":[25,71,158],"further":[26],"analyse":[27],"the":[28,60,86,135],"relationship":[29],"between":[30],"hyperfibrinolysis":[31,73,120,133,154],"bleeding":[33,58,140],"in":[34],"cirrhosis":[35],"by":[36],"measuring":[37],"plasma":[38],"values":[39,79],"D-dimer":[41,81],"tissue":[43],"plasminogen":[44],"activator":[45],"(t-PA)":[46],"activity.":[47,84],"One-hundred-twelve":[48],"cirrhotic":[49,160],"oesophageal":[52],"varices":[53,115],"without":[55],"previous":[56],"upper-gastrointestinal":[57],"entered":[59],"were":[63,69],"followed-up":[64],"for":[65,153],"3":[66],"years.":[67],"Patients":[68],"considered":[70],"have":[72],"if":[74],"they":[75],"concomitantly":[76],"had":[77,93],"t-PA":[83],"During":[85],"follow-up":[87],"34":[88],"(30%)":[89],"bled.":[91],"They":[92],"more":[94],"severe":[95],"liver":[96],"failure":[97],"(p":[98,104,112,121],"=":[99,105,113,122,143],"0.0001)":[100,123],"variceal":[102],"size":[103],"0.0031)":[106],"higher":[108],"prevalence":[109],"ascites":[111],"0.0003),":[114],"red":[117],"signs":[118],"than":[124],"who":[126],"did":[127],"not":[128],"bleed.":[129],"Multivariate":[130],"analysis":[131],"disclosed":[132],"as":[134],"only":[136],"marker":[137],"predictive":[138],"(Hazard":[141],"Ratio":[142],"42.5,":[144],"p":[145],"<":[146],"0.001).":[147],"Our":[148],"findings":[149],"suggest":[150],"that":[151],"screening":[152],"may":[155],"be":[156],"useful":[157],"identify":[159]},"counts_by_year":[{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}