{"id":"https://openalex.org/W12564389","doi":null,"title":"Ancient roles of non-coding RNAs in eukaryotic evolution","display_name":"Ancient roles of non-coding RNAs in eukaryotic evolution","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W12564389","mag":"12564389"},"language":"en","primary_location":{"id":"pmh:oai:pub.epsilon.slu.se:8295","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8295/1/avesson_l_110825.pdf","pdf_url":"https://pub.epsilon.slu.se/8295/1/avesson_l_110825.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pub.epsilon.slu.se/8295/1/avesson_l_110825.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061574598","display_name":"Lotta Avesson","orcid":"https://orcid.org/0000-0002-5526-6768","observed_orcids":["https://orcid.org/0000-0002-5526-6768"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lotta Avesson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5526-6768","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061574598"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.24609999358654022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.22190000116825104,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/eukaryotic-evolution","display_name":"eukaryotic evolution","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dictyostelium-discoideum","display_name":"Dictyostelium discoideum","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.9340000152587891},{"id":"https://openalex.org/keywords/microrna-pathway","display_name":"microRNA pathway","score":0.7580000162124634},{"id":"https://openalex.org/keywords/social-amoebae","display_name":"social amoebae","score":0.9409999847412109},{"id":"https://openalex.org/keywords/signal-recognition-particle-rna","display_name":"signal recognition particle RNA","score":0.9750000238418579},{"id":"https://openalex.org/keywords/giardia-duodenalis","display_name":"Giardia lamblia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.718999981880188},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8180000185966492},{"id":"https://openalex.org/keywords/last-eukaryotic-common-ancestor","display_name":"last eukaryotic common ancestor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5509999990463257},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7755852341651917},{"id":"https://openalex.org/C2775969001","wikidata":"https://www.wikidata.org/wiki/Q134351","display_name":"Dictyostelium discoideum","level":3,"score":0.764898955821991},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.7261300086975098},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5842077136039734},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4184926748275757},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41707369685173035},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4157024323940277},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4044911563396454},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38846397399902344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29092302918434143},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pub.epsilon.slu.se:8295","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8295/1/avesson_l_110825.pdf","pdf_url":"https://pub.epsilon.slu.se/8295/1/avesson_l_110825.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:12564389","doi":null,"is_oa":false,"landing_page_url":"https://pub.epsilon.slu.se/8295/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pub.epsilon.slu.se:8295","doi":null,"is_oa":true,"landing_page_url":"https://pub.epsilon.slu.se/8295/1/avesson_l_110825.pdf","pdf_url":"https://pub.epsilon.slu.se/8295/1/avesson_l_110825.pdf","source":{"id":"https://openalex.org/S4306402317","display_name":"Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I298625061","host_organization_name":"Swedish University of Agricultural Sciences","host_organization_lineage":["https://openalex.org/I298625061"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2949702589","display_name":null,"funder_award_id":"GM 08111","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5066972716","display_name":null,"funder_award_id":"NCRR 03020","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W12564389.pdf","grobid_xml":"https://content.openalex.org/works/W12564389.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1531414226","https://openalex.org/W1625754937","https://openalex.org/W1755332921","https://openalex.org/W1845151788","https://openalex.org/W1892192544","https://openalex.org/W1956319726","https://openalex.org/W1965175512","https://openalex.org/W1966007232","https://openalex.org/W1978010165","https://openalex.org/W1978750764","https://openalex.org/W1978967539","https://openalex.org/W1983641013","https://openalex.org/W1984780475","https://openalex.org/W1986551230","https://openalex.org/W1987332678","https://openalex.org/W1988163167","https://openalex.org/W1991737083","https://openalex.org/W1992741792","https://openalex.org/W1996542013","https://openalex.org/W2001548763","https://openalex.org/W2002529048","https://openalex.org/W2004271888","https://openalex.org/W2006840983","https://openalex.org/W2009644747","https://openalex.org/W2010012954","https://openalex.org/W2010461414","https://openalex.org/W2010890469","https://openalex.org/W2011518477","https://openalex.org/W2013765955","https://openalex.org/W2016943632","https://openalex.org/W2017426710","https://openalex.org/W2018567821","https://openalex.org/W2021581554","https://openalex.org/W2022036343","https://openalex.org/W2023186109","https://openalex.org/W2023762491","https://openalex.org/W2023961115","https://openalex.org/W2025988532","https://openalex.org/W2026570544","https://openalex.org/W2028466333","https://openalex.org/W2030047242","https://openalex.org/W2030489111","https://openalex.org/W2035399581","https://openalex.org/W2036583346","https://openalex.org/W2040648064","https://openalex.org/W2041237942","https://openalex.org/W2043436209","https://openalex.org/W2044131517","https://openalex.org/W2044147350","https://openalex.org/W2046486243","https://openalex.org/W2046584841","https://openalex.org/W2047663395","https://openalex.org/W2047808004","https://openalex.org/W2050110866","https://openalex.org/W2051250838","https://openalex.org/W2055214702","https://openalex.org/W2058480679","https://openalex.org/W2060842569","https://openalex.org/W2061177016","https://openalex.org/W2063040470","https://openalex.org/W2063056851","https://openalex.org/W2065566217","https://openalex.org/W2066157379","https://openalex.org/W2067341081","https://openalex.org/W2068992598","https://openalex.org/W2072972020","https://openalex.org/W2072977772","https://openalex.org/W2074777466","https://openalex.org/W2074990432","https://openalex.org/W2075014899","https://openalex.org/W2077248019","https://openalex.org/W2079320075","https://openalex.org/W2082270407","https://openalex.org/W2086888347","https://openalex.org/W2088722891","https://openalex.org/W2088880262","https://openalex.org/W2090030959","https://openalex.org/W2091222772","https://openalex.org/W2091505905","https://openalex.org/W2095910329","https://openalex.org/W2097337180","https://openalex.org/W2098386120","https://openalex.org/W2098422994","https://openalex.org/W2100806094","https://openalex.org/W2100932663","https://openalex.org/W2102310568","https://openalex.org/W2104135642","https://openalex.org/W2105167622","https://openalex.org/W2108984959","https://openalex.org/W2110361323","https://openalex.org/W2110529457","https://openalex.org/W2121918723","https://openalex.org/W2123079914","https://openalex.org/W2124662626","https://openalex.org/W2126487146","https://openalex.org/W2126804008","https://openalex.org/W2128481981","https://openalex.org/W2128937741","https://openalex.org/W2129173944","https://openalex.org/W2129726167","https://openalex.org/W2133383574","https://openalex.org/W2133968430","https://openalex.org/W2135015580","https://openalex.org/W2136402141","https://openalex.org/W2138664009","https://openalex.org/W2139074713","https://openalex.org/W2141334903","https://openalex.org/W2141921174","https://openalex.org/W2142349465","https://openalex.org/W2145186502","https://openalex.org/W2147114301","https://openalex.org/W2149146789","https://openalex.org/W2152815488","https://openalex.org/W2156852055","https://openalex.org/W2162674813","https://openalex.org/W2163091657","https://openalex.org/W2163199119","https://openalex.org/W2166884499","https://openalex.org/W2169123200","https://openalex.org/W2169590997","https://openalex.org/W2396575323","https://openalex.org/W7073734855","https://openalex.org/W7099865597"],"related_works":["https://openalex.org/W1583331679","https://openalex.org/W2012844271","https://openalex.org/W2075014899","https://openalex.org/W3125478275","https://openalex.org/W7038077734","https://openalex.org/W135973195","https://openalex.org/W3014262680","https://openalex.org/W3093140443","https://openalex.org/W1986551230","https://openalex.org/W4410085690"],"abstract_inverted_index":{"RNAs":[0,6,145,171],"not":[1],"coding":[2],"for":[3,46,99,106,119],"proteins,":[4],"non-coding":[5],"(ncRNAs)":[7],"have":[8,25,142,166,183],"many":[9,107,129],"important":[10,232],"roles":[11,244],"in":[12,18,32,124,128,159,190,205,218,228],"all":[13],"kingdoms":[14],"of":[15,23,35,65,93,132,197,225,237],"life.":[16],"Especially":[17],"eukaryotes,":[19],"the":[20,33,86,94,149,160,185,195,208,222,229,235],"regulatory":[21],"functions":[22],"ncRNAs":[24,44,238],"been":[26],"suggested":[27],"as":[28,102,146,148,239,241],"a":[29,63,82,198],"major":[30],"force":[31],"evolution":[34],"complex":[36],"traits.":[37],"Cellular":[38],"processes":[39],"that":[40],"are":[41],"regulated":[42],"by":[43],"include":[45],"example":[47],"cell":[48],"differentiation,":[49],"organ":[50],"development":[51,115],"and":[52,56,70,73,76,85,114,116,152,193,203,213,245],"defense":[53],"against":[54],"viruses":[55],"transposable":[57],"elements.":[58],"This":[59],"is":[60,81,127],"achieved":[61],"through":[62],"number":[64],"mechanisms":[66],"like":[67,111],"RNA":[68,150,189],"destabilization":[69],"modification,":[71],"transcriptional":[72],"translational":[74],"control":[75],"chromatin":[77],"modifications.":[78],"\\n\\nDictyostelium":[79],"discoideum":[80,126],"social":[83,178],"amoeba":[84],"best":[87],"studied":[88,143],"organism":[89],"representing":[90],"Amoebozoa,":[91],"one":[92],"eukaryotic":[95,162],"supergroups.":[96],"It":[97],"has":[98],"long":[100],"served":[101],"an":[103],"excellent":[104],"model":[105],"basic":[108],"cellular":[109],"events":[110],"chemotaxis,":[112],"differentiation":[113],"recently":[117],"also":[118,135,167,194],"infection.":[120],"The":[121],"ncRNA":[122,199],"population":[123],"D.":[125,219],"ways":[130],"typical":[131],"eukaryotes":[133],"but":[134],"harbors":[136],"particularities.":[137],"In":[138,180],"this":[139],"thesis":[140],"I":[141,165,170],"spliceosomal":[144],"well":[147,209,240],"interference":[151],"microRNA":[153],"pathways,":[154],"which":[155,172],"probably":[156],"were":[157],"present":[158],"last":[161],"common":[163],"ancestor.":[164],"characterized":[168],"Class":[169],"seems":[173],"to":[174,177],"be":[175],"specific":[176],"amoebae.":[179],"addition,":[181],"we":[182],"described":[184],"signal":[186],"recognition":[187],"particle":[188],"several":[191],"protists":[192],"involvement":[196],"during":[200],"host":[201],"interaction":[202],"stress":[204],"Giardia":[206],"lamblia.\\n\\nCombining":[207],"established":[210],"molecular":[211],"tools":[212],"knowledge":[214],"about":[215,234],"various":[216],"pathways":[217],"discoideum,":[220],"with":[221],"growing":[223],"understanding":[224],"ncRNA,":[226],"could":[227],"future":[230],"give":[231],"information":[233],"function":[236],"their":[242],"ancient":[243],"evolution.\\n":[246]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
