{"id":"https://openalex.org/W125601491","doi":"https://doi.org/10.7164/antibiotics.52.1077","title":"Production of a Family of Kinase-inhibiting Lactones from Fungal.","display_name":"Production of a Family of Kinase-inhibiting Lactones from Fungal.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W125601491","doi":"https://doi.org/10.7164/antibiotics.52.1077","mag":"125601491","pmid":"https://pubmed.ncbi.nlm.nih.gov/10695670"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.52.1077","doi":"https://doi.org/10.7164/antibiotics.52.1077","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.52.1077","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/52/12/52_12_1077/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/52/12/52_12_1077/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075371574","display_name":"Anne W. Dombrowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANNE DOMBROWSKI","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111675907","display_name":"Rosalind G. Jenkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROSALIND JENKINS","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084497696","display_name":"Susan L. Raghoobar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SUSAN RAGHOOBAR","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031888544","display_name":"Gerald F. Bills","orcid":"https://orcid.org/0000-0003-2352-8417","observed_orcids":["https://orcid.org/0000-0003-2352-8417"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GERALD BILLS","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069557008","display_name":"Jon D. Polishook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JON POLISHOOK","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090732329","display_name":"Fernando Pel\u00e1ez","orcid":"https://orcid.org/0000-0002-4861-586X","observed_orcids":["https://orcid.org/0000-0002-4861-586X"]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"FERNANDO PEL\u00c1EZ","raw_affiliation_strings":["Merck Sharp & Dohme de Espa\u00f1a","Merck Sharp and Dohme de Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Sharp & Dohme de Espa\u00f1a","institution_ids":["https://openalex.org/I4210144418"]},{"raw_affiliation_string":"Merck Sharp and Dohme de Espa\u00f1a","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056001075","display_name":"Bruce Burgess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BRUCE BURGESS","raw_affiliation_strings":["Merck Manufacturing Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Manufacturing Division","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109449415","display_name":"Annie Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANNIE ZHAO","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110105081","display_name":"Leeyuan Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LEEYUAN HUANG","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"YAN ZHANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YAN ZHANG","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110148964","display_name":"MICHAEL A. GOETZ","orcid":"https://orcid.org/0000-0003-0984-224X","observed_orcids":["https://orcid.org/0000-0003-0984-224X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL GOETZ","raw_affiliation_strings":["Merck Research Laboratories","Merck Research Labs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Labs","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.7846,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.65078506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"52","issue":"12","first_page":"1077","last_page":"1085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resorcylic-acid-lactones","display_name":"resorcylic acid lactones","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fungal-natural-products","display_name":"fungal natural products","score":0.9079999923706055},{"id":"https://openalex.org/keywords/fermentation-optimization","display_name":"fermentation optimization","score":0.7670000195503235},{"id":"https://openalex.org/keywords/media-composition","display_name":"media composition","score":0.7300000190734863},{"id":"https://openalex.org/keywords/secondary-metabolite-production","display_name":"secondary metabolite production","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.6494531035423279},{"id":"https://openalex.org/C2776612806","wikidata":"https://www.wikidata.org/wiki/Q59078","display_name":"Lactone","level":2,"score":0.5450471043586731},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5161057710647583},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4801896810531616},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47195664048194885},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.4427955746650696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40925148129463196},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.52.1077","doi":"https://doi.org/10.7164/antibiotics.52.1077","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.52.1077","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/52/12/52_12_1077/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:10695670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10695670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.52.1077","doi":"https://doi.org/10.7164/antibiotics.52.1077","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.52.1077","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/52/12/52_12_1077/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W125601491.pdf","grobid_xml":"https://content.openalex.org/works/W125601491.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W363037004","https://openalex.org/W1563080566","https://openalex.org/W1971915141","https://openalex.org/W1974360015","https://openalex.org/W1979745165","https://openalex.org/W1989480480","https://openalex.org/W2035936653","https://openalex.org/W2042776245","https://openalex.org/W2059852645","https://openalex.org/W2061672016","https://openalex.org/W2086262311","https://openalex.org/W2133845704","https://openalex.org/W2330333663"],"related_works":["https://openalex.org/W363037004","https://openalex.org/W2949208397","https://openalex.org/W3175778091","https://openalex.org/W2161354388","https://openalex.org/W2093239060","https://openalex.org/W2414229810","https://openalex.org/W7071602360","https://openalex.org/W2017584520","https://openalex.org/W362052247","https://openalex.org/W2069809186"],"abstract_inverted_index":{"During":[0],"the":[1,42,45,52,57],"course":[2],"of":[3,12,21,31,38,44,47,56,69],"our":[4],"screening":[5],"for":[6],"natural":[7],"products":[8],"from":[9],"fungi,":[10],"extracts":[11],"several":[13],"cultures":[14],"were":[15,65],"found":[16],"to":[17],"make":[18],"a":[19],"family":[20],"related":[22],"resorcylic":[23],"acid":[24],"lactone":[25],"compounds,":[26],"which":[27],"are":[28],"potent":[29],"inhibitors":[30],"MEK":[32],"kinase.":[33],"Comparative":[34],"and":[35,54,59],"empirical":[36],"studies":[37],"fermentation":[39],"conditions":[40],"improved":[41],"titers":[43],"compounds":[46,61],"interest.":[48],"Striking":[49],"changes":[50],"in":[51,62],"ratios":[53],"amounts":[55],"major":[58],"minor":[60],"some":[63],"cases":[64],"achieved":[66],"by":[67],"manipulations":[68],"media":[70],"composition.":[71]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
