{"id":"https://openalex.org/W125535151","doi":null,"title":"Nucleoredoxin and Wnt signaling in F9 cells","display_name":"Nucleoredoxin and Wnt signaling in F9 cells","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W125535151","mag":"125535151"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2350","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/977","pdf_url":"https://uwo.scholaris.ca/bitstreams/0aa35993-b70e-4453-8593-43fe5e34bb4a/download","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uwo.scholaris.ca/bitstreams/0aa35993-b70e-4453-8593-43fe5e34bb4a/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005419336","display_name":"Leanne Sandieson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leanne Sandieson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005419336"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00842685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleoredoxin","display_name":"nucleoredoxin","score":1.0},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dishevelled","display_name":"Dishevelled","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dishevelled-2","display_name":"Dishevelled 2","score":0.9440000057220459},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.878000020980835},{"id":"https://openalex.org/keywords/f9-cells","display_name":"F9 cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tcf-lef","display_name":"TCF/LEF","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6259999871253967},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2775928862","wikidata":"https://www.wikidata.org/wiki/Q5282208","display_name":"Dishevelled","level":5,"score":0.9843406081199646},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9301263093948364},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.7718050479888916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7330793142318726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4693623185157776},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46296289563179016},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.44400861859321594},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.43780261278152466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3920808434486389},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3563663959503174},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.21545210480690002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12182790040969849},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11345720291137695}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-2350","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/977","pdf_url":"https://uwo.scholaris.ca/bitstreams/0aa35993-b70e-4453-8593-43fe5e34bb4a/download","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/37383","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/37383","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:125535151","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2350&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2350","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/977","pdf_url":"https://uwo.scholaris.ca/bitstreams/0aa35993-b70e-4453-8593-43fe5e34bb4a/download","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W125535151.pdf","grobid_xml":"https://content.openalex.org/works/W125535151.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W220993559","https://openalex.org/W1966672647","https://openalex.org/W1969268163","https://openalex.org/W1971383450","https://openalex.org/W1975770985","https://openalex.org/W1978559606","https://openalex.org/W1978880986","https://openalex.org/W1982328999","https://openalex.org/W1985014243","https://openalex.org/W1990134219","https://openalex.org/W1998963240","https://openalex.org/W2000260860","https://openalex.org/W2005440429","https://openalex.org/W2006077145","https://openalex.org/W2009640428","https://openalex.org/W2010898380","https://openalex.org/W2012325549","https://openalex.org/W2015766782","https://openalex.org/W2020555116","https://openalex.org/W2021849630","https://openalex.org/W2026061437","https://openalex.org/W2027414519","https://openalex.org/W2033800625","https://openalex.org/W2045715881","https://openalex.org/W2055828191","https://openalex.org/W2059674440","https://openalex.org/W2062080431","https://openalex.org/W2063167831","https://openalex.org/W2064197222","https://openalex.org/W2069196243","https://openalex.org/W2070547356","https://openalex.org/W2075647419","https://openalex.org/W2076812266","https://openalex.org/W2077351642","https://openalex.org/W2085719701","https://openalex.org/W2092463196","https://openalex.org/W2100701799","https://openalex.org/W2123829995","https://openalex.org/W2131797170","https://openalex.org/W2132104888","https://openalex.org/W2149668250","https://openalex.org/W2161464353","https://openalex.org/W2162614738","https://openalex.org/W2342577875","https://openalex.org/W2793841049","https://openalex.org/W4300058229"],"related_works":["https://openalex.org/W8054396","https://openalex.org/W2027414519","https://openalex.org/W2054062221","https://openalex.org/W2413984557","https://openalex.org/W1998963240","https://openalex.org/W2102282081","https://openalex.org/W2019532871","https://openalex.org/W2295790887","https://openalex.org/W2140605534","https://openalex.org/W2004369036"],"abstract_inverted_index":{"Nucleoredoxin":[0],"is":[1,20,65,139],"a":[2,24,57],"redox":[3,140],"sensitive":[4],"protein":[5],"recently":[6],"shown":[7],"to":[8,42,44,59,95,97],"be":[9],"involved":[10,66],"in":[11,47,67,88],"the":[12,32,37,69,125,130,143],"Wnt/\u03b2-catenin":[13,70,131],"pathway":[14,133],"through":[15],"binding":[16],"dishevelled.":[17],"When":[18],"Wnt":[19],"present,":[21],"dishevelled":[22,84],"prevents":[23],"destruction":[25],"complex":[26],"from":[27],"degrading":[28],"\u03b2-catenin.":[29],"This":[30,50],"facilitates":[31],"translocation":[33],"of":[34,145],"\u03b2-catenin":[35],"into":[36,121],"nucleus":[38],"where":[39],"it":[40],"binds":[41],"TCF-LEF":[43],"impart":[45],"changes":[46],"gene":[48],"expression.":[49],"study":[51],"used":[52],"mouse":[53],"F9":[54,89,118],"cells":[55,101,119],"as":[56],"model":[58],"examine":[60],"whether":[61],"or":[62],"not":[63],"nucleoredoxin":[64,81,92,113],"augmenting":[68],"signaling":[71,132],"required":[72],"for":[73,135],"extraembryonic":[74,122,136],"endoderm":[75,137],"differentiation.":[76],"It":[77],"was":[78,93,115],"found":[79,94],"that":[80,129],"and":[82,99],"three":[83],"isoforms":[85],"were":[86,102],"present":[87],"cells.":[90],"Furthermore,":[91],"bind":[96],"dishevelled-2,":[98],"when":[100,112],"treated":[103],"with":[104],"an":[105],"oxidizing":[106],"agent":[107],"this":[108],"interaction":[109],"diminished.":[110],"Lastly,":[111],"expression":[114],"knocked":[116],"down,":[117],"differentiated":[120],"endoderm.":[123],"Together,":[124],"data":[126],"would":[127],"indicate":[128],"obligatory":[134],"differentiation":[138],"regulated":[141],"at":[142],"level":[144],"nucleoredoxin.":[146]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}