{"id":"https://openalex.org/W125369182","doi":null,"title":"Titanium Oxide and Bone Anchorage: Role of the Complement System, and Delivery of Osteoporosis Drugs from Mesoporous TiO2","display_name":"Titanium Oxide and Bone Anchorage: Role of the Complement System, and Delivery of Osteoporosis Drugs from Mesoporous TiO2","publication_year":2014,"publication_date":"2014-03-07","ids":{"openalex":"https://openalex.org/W125369182","mag":"125369182"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/34402","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/34402","pdf_url":"http://hdl.handle.net/2077/34402","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/34402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010016616","display_name":"Necati Harmankaya","orcid":"https://orcid.org/0000-0003-4489-0722","observed_orcids":["https://orcid.org/0000-0003-4489-0722"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Necati Harmankaya","raw_affiliation_strings":["University of Gothenburg"],"raw_orcid":"https://orcid.org/0000-0003-4489-0722","affiliations":[{"raw_affiliation_string":"University of Gothenburg","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010016616"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.16220000386238098,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11442","display_name":"Titanium Alloys Microstructure and Properties","score":0.09049999713897705,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.8690000176429749},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.9200000166893005},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/complement-c3-deposition","display_name":"C3 deposition","score":0.6200000047683716},{"id":"https://openalex.org/keywords/uv-ozone-treatment","display_name":"UV-ozone treatment","score":0.7440000176429749},{"id":"https://openalex.org/keywords/heat-treatment","display_name":"heat treatment","score":0.8370000123977661},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7919999957084656},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":1.0},{"id":"https://openalex.org/keywords/ovariectomized-rats","display_name":"ovariectomized rats","score":0.7900000214576721},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/surface-modification","display_name":"surface modification","score":0.4320000112056732},{"id":"https://openalex.org/keywords/evaporation-induced-self-assembly","display_name":"evaporation-induced self-assembly","score":0.6949999928474426},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6569781303405762},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.586143970489502},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.45406267046928406},{"id":"https://openalex.org/C506065880","wikidata":"https://www.wikidata.org/wiki/Q716","display_name":"Titanium","level":2,"score":0.45043209195137024},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.42922890186309814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4151521623134613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3078162670135498},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2492264211177826},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23822501301765442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2326734960079193},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22725218534469604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1503482162952423},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.11663642525672913},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/34402","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/34402","pdf_url":"http://hdl.handle.net/2077/34402","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:125369182","doi":null,"is_oa":false,"landing_page_url":"https://guoa.ub.gu.se/bitstream/2077/34402/1/gupea_2077_34402_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/34402","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/34402","pdf_url":"http://hdl.handle.net/2077/34402","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W125369182.pdf","grobid_xml":"https://content.openalex.org/works/W125369182.grobid-xml"},"referenced_works_count":176,"referenced_works":["https://openalex.org/W76298574","https://openalex.org/W175660244","https://openalex.org/W639320693","https://openalex.org/W1257791202","https://openalex.org/W1489454155","https://openalex.org/W1499500424","https://openalex.org/W1514081838","https://openalex.org/W1562125623","https://openalex.org/W1655460658","https://openalex.org/W1666890712","https://openalex.org/W1817443571","https://openalex.org/W1964292964","https://openalex.org/W1964509005","https://openalex.org/W1966584864","https://openalex.org/W1967492863","https://openalex.org/W1968024679","https://openalex.org/W1968822620","https://openalex.org/W1969618807","https://openalex.org/W1969753873","https://openalex.org/W1969945802","https://openalex.org/W1970043429","https://openalex.org/W1970158391","https://openalex.org/W1970708343","https://openalex.org/W1972604665","https://openalex.org/W1973707842","https://openalex.org/W1974619793","https://openalex.org/W1974670251","https://openalex.org/W1975145454","https://openalex.org/W1978398769","https://openalex.org/W1980481528","https://openalex.org/W1980627681","https://openalex.org/W1980782312","https://openalex.org/W1981532226","https://openalex.org/W1981803131","https://openalex.org/W1982912854","https://openalex.org/W1983090947","https://openalex.org/W1984087235","https://openalex.org/W1985184665","https://openalex.org/W1986053269","https://openalex.org/W1986261297","https://openalex.org/W1987059825","https://openalex.org/W1989034395","https://openalex.org/W1991053758","https://openalex.org/W1991540139","https://openalex.org/W1991802103","https://openalex.org/W1992453836","https://openalex.org/W1992766495","https://openalex.org/W1994414479","https://openalex.org/W1995041236","https://openalex.org/W1995063875","https://openalex.org/W1996620821","https://openalex.org/W1997283540","https://openalex.org/W1998945181","https://openalex.org/W2000111747","https://openalex.org/W2003158379","https://openalex.org/W2003733256","https://openalex.org/W2005528887","https://openalex.org/W2005726028","https://openalex.org/W2006821764","https://openalex.org/W2007808060","https://openalex.org/W2008511214","https://openalex.org/W2008952772","https://openalex.org/W2009079495","https://openalex.org/W2011780004","https://openalex.org/W2012270515","https://openalex.org/W2013746255","https://openalex.org/W2013867761","https://openalex.org/W2015392341","https://openalex.org/W2016099549","https://openalex.org/W2018699427","https://openalex.org/W2019812544","https://openalex.org/W2019974313","https://openalex.org/W2020056894","https://openalex.org/W2022898508","https://openalex.org/W2023447679","https://openalex.org/W2023472353","https://openalex.org/W2024308870","https://openalex.org/W2026607169","https://openalex.org/W2026679068","https://openalex.org/W2027653189","https://openalex.org/W2028749231","https://openalex.org/W2030215185","https://openalex.org/W2030913739","https://openalex.org/W2033335872","https://openalex.org/W2033451240","https://openalex.org/W2034608078","https://openalex.org/W2035073111","https://openalex.org/W2035785041","https://openalex.org/W2038050797","https://openalex.org/W2039895905","https://openalex.org/W2042073777","https://openalex.org/W2042474003","https://openalex.org/W2042492216","https://openalex.org/W2042602209","https://openalex.org/W2045068030","https://openalex.org/W2045369683","https://openalex.org/W2045813307","https://openalex.org/W2048427203","https://openalex.org/W2048762954","https://openalex.org/W2050305033","https://openalex.org/W2051036247","https://openalex.org/W2052232074","https://openalex.org/W2052864632","https://openalex.org/W2054616090","https://openalex.org/W2056657069","https://openalex.org/W2057334878","https://openalex.org/W2060185839","https://openalex.org/W2060963812","https://openalex.org/W2061214110","https://openalex.org/W2065644096","https://openalex.org/W2066646366","https://openalex.org/W2069752424","https://openalex.org/W2071424589","https://openalex.org/W2071564049","https://openalex.org/W2076107807","https://openalex.org/W2078765207","https://openalex.org/W2081648801","https://openalex.org/W2085173237","https://openalex.org/W2085392426","https://openalex.org/W2086596620","https://openalex.org/W2089224387","https://openalex.org/W2092761820","https://openalex.org/W2096467350","https://openalex.org/W2098190902","https://openalex.org/W2099083931","https://openalex.org/W2099580984","https://openalex.org/W2100287780","https://openalex.org/W2101111540","https://openalex.org/W2105726304","https://openalex.org/W2108244474","https://openalex.org/W2108897036","https://openalex.org/W2112072108","https://openalex.org/W2121369239","https://openalex.org/W2125809186","https://openalex.org/W2128525211","https://openalex.org/W2129403931","https://openalex.org/W2130683541","https://openalex.org/W2131130317","https://openalex.org/W2131350538","https://openalex.org/W2131694872","https://openalex.org/W2132905138","https://openalex.org/W2133111205","https://openalex.org/W2133819222","https://openalex.org/W2139360111","https://openalex.org/W2145430157","https://openalex.org/W2147060741","https://openalex.org/W2151005356","https://openalex.org/W2152825833","https://openalex.org/W2154216995","https://openalex.org/W2154761626","https://openalex.org/W2160546293","https://openalex.org/W2163092949","https://openalex.org/W2163768016","https://openalex.org/W2164518326","https://openalex.org/W2165268759","https://openalex.org/W2167022931","https://openalex.org/W2167071495","https://openalex.org/W2168225618","https://openalex.org/W2169156291","https://openalex.org/W2173053672","https://openalex.org/W2226891106","https://openalex.org/W2243075302","https://openalex.org/W2312199777","https://openalex.org/W2312945397","https://openalex.org/W2316920904","https://openalex.org/W2336969031","https://openalex.org/W2337252879","https://openalex.org/W2413470015","https://openalex.org/W2416643905","https://openalex.org/W2469917022","https://openalex.org/W2471984307","https://openalex.org/W2482023145","https://openalex.org/W2794123422","https://openalex.org/W2898807999","https://openalex.org/W2991587873","https://openalex.org/W3172713090"],"related_works":["https://openalex.org/W1975173930","https://openalex.org/W1992453836","https://openalex.org/W2153800961","https://openalex.org/W2061322244","https://openalex.org/W2064758380","https://openalex.org/W3213312504","https://openalex.org/W2599455829","https://openalex.org/W1480558309","https://openalex.org/W2519676186","https://openalex.org/W3013128212"],"abstract_inverted_index":{"The":[0,178,218,375],"clinical":[1],"success":[2],"of":[3,6,20,53,62,81,109,170,227,265,293,370,377,404,418,433,439,451],"bone":[4,181,381],"implants":[5,63,249,302,328],"titanium":[7],"(Ti)":[8],"is":[9,45],"largely":[10],"ascribed":[11],"to":[12,35,41,68,96,103,136,139,164,183,187,304,345,357,386,475,492],"the":[13,17,21,54,105,110,168,212,245,248,311,317,390,401,405,420,430,440],"biological":[14],"performance":[15],"and":[16,39,43,51,87,146,153,167,197,230,247,256,359,362,372,389],"physicochemical":[18],"properties":[19,86,432],"outermost":[22],"titanium(IV)dioxide":[23],"(TiO2)":[24],"layer.":[25],"Several":[26],"advancements":[27],"have":[28,409,444],"been":[29],"done":[30],"on":[31,125,204,300,315,463],"TiO2":[32,82,122,223,434],"in":[33,90,115,141,151,154,159,179,252,254,269,355,379,400],"order":[34],"optimize":[36],"its":[37],"healing":[38],"anchorage":[40,89],"bone,":[42],"there":[44],"a":[46,117,225,232,331,351,396,424,460,476],"need":[47],"for":[48,134,148,162,283,384,481],"further":[49],"understanding":[50],"control":[52,104,190,358],"molecular":[55,71],"reactions":[56],"preceding":[57],"long-term":[58],"osseointegration.":[59],"Next":[60],"generation":[61],"advance":[64],"with":[65,83,143,224,330,497],"their":[66],"ability":[67,108],"target":[69],"specific":[70],"mechanisms.":[72],"\\nIn":[73],"this":[74,324],"thesis":[75],"we":[76,93,113,408,443],"performed":[77],"mild":[78,100,118,276,452],"surface":[79,191],"treatments":[80,490],"improved":[84],"oxide":[85],"bone-implant":[88,427,478],"mind.":[91],"First,":[92],"exposed":[94,133],"Ti":[95,126,185,205,327],"(UV)":[97],"illumination":[98],"or":[99,132,240,281,286,334,454,494],"heat":[101,119,277],"treatment":[102,278],"complement":[106,171,188,266],"activation":[107],"surfaces.":[111],"Secondly,":[112],"evaluated":[114,175,193,251],"vivo":[116,180,253,299],"treated":[120],"mesoporous":[121,200,222],"drug-delivery":[123],"system":[124],"implants.":[127,406],"\\nTi":[128],"surfaces":[129,465],"were":[130,157,242,250,340],"heated":[131],"up":[135,163,344,385],"96":[137],"hours":[138,285],"UV-light":[140],"combination":[142],"ozone":[144],"(UVO)":[145],"tested":[147],"inflammatory":[149,294,313],"activity":[150],"situ":[152,270],"vivo.":[155],"Surfaces":[156],"immersed":[158],"blood":[160],"plasma":[161],"60":[165],"minutes":[166],"deposition":[169],"factor":[172,267],"C3":[173,268],"was":[174,192,202,220,296,363,382],"by":[176,194,275,365,449],"ellipsometry.":[177],"response":[182,314],"UVO-treated":[184,301],"relative":[186],"activating":[189],"histology,":[195],"histomorphometry,":[196],"biomechanics.":[198],"\\nThe":[199],"coating":[201,219],"prepared":[203],"screws":[206],"(L=2.3":[207],"mm,":[208],"\u00d8=2.0":[209],"mm)":[210],"using":[211],"Evaporation":[213],"Induced":[214],"Self-Assembly":[215],"(EISA)":[216],"method.":[217],"highly-ordered":[221],"thickness":[226],"200":[228],"nm":[229],"possessed":[231],"narrow":[233],"pore-size":[234],"distribution.":[235],"Two":[236],"osteoporosis":[237],"drugs,":[238],"alendronate":[239,378,394],"raloxifene,":[241],"absorbed":[243],"into":[244,466],"pores":[246],"male":[255],"ovariectomized":[257],"rat":[258],"models.\\nThe":[259],"present":[260],"results":[261,391],"show":[262,392],"that":[263,393],"adsorption":[264],"can":[271,446,469],"be":[272,447,470],"strongly":[273],"suppressed":[274],"at":[279,503],"300\u00b0C":[280],"UVO-treatment":[282,308],"12":[284],"longer.":[287],"A":[288],"significantly":[289,321,352,425],"lower":[290],"gene":[291,368],"expression":[292,369],"markers":[295],"noted":[297],"ex":[298],"compared":[303],"complement-activating":[305],"controls.":[306],"Although":[307],"did":[309,319],"attenuate":[310],"early":[312],"Ti,":[316],"bone-anchorage":[318,354],"not":[320],"benefit":[322],"from":[323,437,484],"effect.":[325],"\\nMesoporous":[326],"loaded":[329],"bisphosphonate,":[332],"alendronate,":[333],"an":[335,366],"oestrogen":[336],"receptor":[337],"antagonist,":[338],"raloxifene":[339],"successfully":[341],"retrieved":[342],"after":[343],"28":[346],"days":[347],"post-surgery.":[348],"Raloxifene":[349],"promoted":[350,423],"higher":[353,426],"comparison":[356],"ALN-loaded":[360],"implants,":[361],"supported":[364],"increased":[367],"osteoblast":[371],"osteoclast":[373],"markers.":[374],"distribution":[376],"implant-close":[380],"followed":[383],"8":[387],"weeks":[388],"has":[395],"long":[397],"residence":[398],"time":[399],"close":[402],"vicinity":[403],"Also,":[407],"shown":[410],"significant":[411],"differences":[412],"between":[413],"local":[414,421],"vs.":[415],"systemic":[416,498],"delivery":[417,422],"bisphosphonates;":[419],"anchorage.\\nIn":[428],"summary,":[429],"osteoimmunologic":[431],"result":[435],"partly":[436],"stoichiometry":[438],"oxide,":[441],"which":[442,467],"showed":[445],"altered":[448],"means":[450],"heat-treatment":[453],"UVO-illumination.":[455],"Mesoporous":[456],"coatings":[457],"may":[458,473],"provide":[459],"unique":[461],"reservoir":[462],"implant":[464],"drugs":[468],"loaded.":[471],"This":[472],"serve":[474],"better":[477],"healing,":[479],"especially":[480],"patients":[482],"suffering":[483],"osteoporotic":[485],"bone-deficiency,":[486],"where":[487],"current":[488],"pharmaceutical":[489],"come":[491],"short":[493],"are":[495],"bound":[496],"side":[499],"effects":[500],"when":[501],"given":[502],"high":[504],"doses.":[505]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}