{"id":"https://openalex.org/W125166756","doi":null,"title":"L-thyroxin treatment and post-menopausal osteoporosis: relevance of the risk profile present in clinical history.","display_name":"L-thyroxin treatment and post-menopausal osteoporosis: relevance of the risk profile present in clinical history.","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W125166756","mag":"125166756","pmid":"https://pubmed.ncbi.nlm.nih.gov/18981975"},"language":"en","primary_location":{"id":"pmid:18981975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18981975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva ginecologica","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053379997","display_name":"Sandro La Vignera","orcid":"https://orcid.org/0000-0002-7113-2372","observed_orcids":["https://orcid.org/0000-0002-7113-2372"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S La Vignera","raw_affiliation_strings":["Section of Endocrinology, Andrology and Internal Medicine, Department of Biomedical Sciences, University of Catania, Catania, Italy. sandrolavignera@email.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Endocrinology, Andrology and Internal Medicine, Department of Biomedical Sciences, University of Catania, Catania, Italy. sandrolavignera@email.it","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050749844","display_name":"Enzo Saretto Dante Vicari","orcid":"https://orcid.org/0000-0003-0243-2942","observed_orcids":["https://orcid.org/0000-0003-0243-2942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Vicari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046084794","display_name":"Dario Tumino","orcid":"https://orcid.org/0000-0003-1021-6692","observed_orcids":["https://orcid.org/0000-0003-1021-6692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Tumino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112147744","display_name":"Lilliana Ciotta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Ciotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087738837","display_name":"Rosita Angela Condorelli","orcid":"https://orcid.org/0000-0002-5217-9343","observed_orcids":["https://orcid.org/0000-0002-5217-9343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Condorelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L O Vicari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L O Vicari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050080012","display_name":"Aldo Eugenio Calogero","orcid":"https://orcid.org/0000-0001-6950-335X","observed_orcids":["https://orcid.org/0000-0001-6950-335X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Calogero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5184,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.87662507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"6","first_page":"475","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.953000009059906},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nodular-thyroid-disease","display_name":"nodular thyroid disease","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tsh-suppression","display_name":"TSH suppression","score":0.7889999747276306},{"id":"https://openalex.org/keywords/thyroid-autoantibodies","display_name":"thyroid autoantibodies","score":0.7940000295639038},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.40400001406669617},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.4790000021457672},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6309999823570251},{"id":"https://openalex.org/keywords/amenorrhea","display_name":"amenorrhea","score":0.7229999899864197},{"id":"https://openalex.org/keywords/nulliparity","display_name":"nulliparity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/surgical-menopause","display_name":"surgical menopause","score":0.734000027179718},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/urinary-hydroxyproline","display_name":"urinary hydroxyproline","score":0.9549999833106995},{"id":"https://openalex.org/keywords/thyroid-hormone-replacement-therapy","display_name":"thyroid hormone replacement","score":0.36899998784065247},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9586861729621887},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.6777256727218628},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.674257218837738},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6502475738525391},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5287282466888428},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5058140754699707},{"id":"https://openalex.org/C2776697488","wikidata":"https://www.wikidata.org/wiki/Q4210589","display_name":"Urinary calcium","level":3,"score":0.4540345370769501},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.43033742904663086},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.41760823130607605},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3859517574310303},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.3793395459651947},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34047064185142517},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006044","descriptor_name":"Goiter, Nodular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006909","descriptor_name":"Hydroxyproline","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18981975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18981975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva ginecologica","raw_type":"Comparative Study"},{"id":"mag:125166756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18981975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149919589","https://openalex.org/W2036870860","https://openalex.org/W7099413001","https://openalex.org/W1992215315","https://openalex.org/W195728614","https://openalex.org/W2005202722","https://openalex.org/W7160226480","https://openalex.org/W2596936568","https://openalex.org/W2119299741","https://openalex.org/W2126806156"],"abstract_inverted_index":{"AIM:":[0],"Nodular":[1],"thyroid":[2,80,146,154,312,366],"disease":[3,81,147,367],"and":[4,123,129,169,173,178,230,306,335,368],"osteoporosis":[5,108],"share":[6],"some":[7,103],"common":[8],"factors":[9,106,262,341],"such":[10],"as:":[11],"1)":[12,271],"elevated":[13],"frequency":[14],"in":[15,22,37,56,85,98,264,317,332],"the":[16,23,30,40,50,69,75,83,100,110,142,150,191,202,215,269,278,283,322,338,362],"general":[17],"population;":[18],"2)":[19,26,277],"major":[20],"prevalence":[21],"female":[24],"sex;":[25],"incidence":[27],"proportional":[28],"to":[29,65,67],"age.":[31],"There":[32],"is":[33],"a":[34,136,209,265],"wide":[35],"debate":[36],"literature":[38],"regarding":[39],"real":[41],"impact":[42],"of":[43,61,71,77,91,102,118,133,139,144,176,190,197,214,220,227,233,280,285,293,302,309,350,353,358],"chronic":[44],"treatment":[45,76,143,205,249,316,325],"with":[46,135,206,223,238,330],"L-thyroxin":[47],"(LT4)":[48],"on":[49,82,109,204],"bone":[51],"mineral":[52,181],"density":[53,182],"(BMD),":[54],"especially":[55],"post-menopausal":[57,86],"women.":[58],"The":[59,195,259],"aim":[60],"this":[62,198,333],"study":[63,199],"was":[64,96,184],"undertake":[66],"evaluate":[68],"effects":[70],"LT4":[72,140,207,248,315],"administration":[73],"for":[74,107,141,291],"normo-functioning":[78],"nodular":[79,145],"BMD":[84,216],"women":[87,117,319],"after":[88,130,217,282],"one":[89],"year":[90,132,219],"continuative":[92],"treatment.":[93],"Particular":[94],"attention":[95],"paid":[97],"examining":[99],"role":[101],"anamnestic":[104],"risk":[105,261,340],"clinical":[111],"response.":[112],"METHODS:":[113],"Ninety":[114],"nine":[115],"postmenopausal":[116,318],"age":[119,284],"comprised":[120],"between":[121,236],"50":[122],"56":[124],"years":[125],"were":[126],"examined":[127],"before":[128],"1":[131,218],"therapy":[134],"fixed":[137],"dose":[138],"by":[148,186],"monitoring":[149],"following":[151,247,260,339],"laboratory":[152],"parameters:":[153],"stimulating":[155],"hormone":[156],"(TSH),":[157],"FT4,":[158],"FT3,":[159],"antithyroglobulin":[160],"antibodies":[161,165],"[AbTG],":[162],"hyroid":[163],"peroxidase":[164],"[AbTPO],":[166],"serum":[167,225],"calcium":[168,177],"alkaline":[170,228],"phosphatase":[171,229],"levels":[172,226],"24-urinary":[174],"excretion":[175,232],"hydroxyproline.":[179,234],"Bone":[180],"(BMD)":[183],"measured":[185],"dual":[187],"X-ray":[188],"absorptiometry":[189],"lumbar":[192],"vertebrae.":[193],"RESULTS:":[194],"results":[196],"showed":[200,250],"that":[201,251],"patients":[203,237,254],"have":[208],"slight,":[210],"but":[211],"significant":[212,267],"reduction":[213],"treatment,":[221,355],"associated":[222],"increased":[224],"urinary":[231],"Comparison":[235],"unsuppressed":[239],"(group":[240,244],"A)":[241],"or":[242],"suppressed":[243],"B)":[245],"TSH":[246],"group":[252],"B":[253],"had":[255],"significantly":[256,321],"lower":[257],"BMD.":[258,323],"influenced,":[263],"statistically":[266],"manner,":[268],"BMD:":[270],"Body":[272],"Mass":[273],"Index":[274],"<19":[275],"kg/m(2);":[276],"onset":[279],"menarche":[281],"15":[286],"years;":[287],"3)":[288],"history":[289,349,357],"positive":[290,356],"period":[292],"amenorrhoea;":[294],"4)":[295],"nulliparity;":[296],"5)":[297],"surgical":[298],"menopause;":[299],"6)":[300],"lack":[301],"hormonal":[303,354],"replacement":[304],"therapy;":[305],"7)":[307],"presence":[308],"auto-antibodies":[310],"against":[311],"antigens.":[313],"CONCLUSION:":[314],"reduced":[320],"This":[324],"should":[326],"be":[327],"therefore":[328],"prescribed":[329],"caution":[331],"condition":[334],"particularly":[336],"when":[337],"are":[342],"present:":[343],"surgically":[344],"driven":[345],"menopause,":[346],"constitutional":[347],"thinness,":[348],"nulliparity,":[351],"absence":[352],"secondary":[359],"amenorrhoea":[360],"during":[361],"reproductive":[363],"age,":[364],"autoimmune":[365],"delayed":[369],"menarche.":[370]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
