{"id":"https://openalex.org/W1249643146","doi":"https://doi.org/10.1158/1538-7445.panca2014-a71","title":"Abstract A71: Post-transcriptional regulation of the proto-oncogene PIM1 by the mRNA stability factor HuR: implications for pancreatic cancer therapeutic response and cell survival","display_name":"Abstract A71: Post-transcriptional regulation of the proto-oncogene PIM1 by the mRNA stability factor HuR: implications for pancreatic cancer therapeutic response and cell survival","publication_year":2015,"publication_date":"2015-06-30","ids":{"openalex":"https://openalex.org/W1249643146","doi":"https://doi.org/10.1158/1538-7445.panca2014-a71","mag":"1249643146"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca2014-a71","doi":"https://doi.org/10.1158/1538-7445.panca2014-a71","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca2014-a71","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034677682","display_name":"Fernando F. Blanco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando F. Blanco","raw_affiliation_strings":["1Thomas Jefferson University, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson University, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078662144","display_name":"Nicole C. Meisner-Kober","orcid":"https://orcid.org/0000-0003-0912-5902","observed_orcids":["https://orcid.org/0000-0003-0912-5902"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicole Meisner-Kober","raw_affiliation_strings":["2Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047890254","display_name":"Eric R. Londin","orcid":"https://orcid.org/0000-0003-4331-6366","observed_orcids":["https://orcid.org/0000-0003-4331-6366"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Londin","raw_affiliation_strings":["1Thomas Jefferson University, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson University, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054046136","display_name":"Isidore Rigoutsos","orcid":"https://orcid.org/0000-0003-1529-8631","observed_orcids":["https://orcid.org/0000-0003-1529-8631"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isidore Rigoutsos","raw_affiliation_strings":["1Thomas Jefferson University, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson University, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067354904","display_name":"Jordan Michael Winter","orcid":"https://orcid.org/0000-0002-5200-6557","observed_orcids":["https://orcid.org/0000-0002-5200-6557"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Winter","raw_affiliation_strings":["1Thomas Jefferson University, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson University, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025415933","display_name":"Charles J. Yeo","orcid":"https://orcid.org/0000-0001-8097-0071","observed_orcids":["https://orcid.org/0000-0001-8097-0071"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Yeo","raw_affiliation_strings":["1Thomas Jefferson University, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson University, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079398934","display_name":"Jonathan Robert Brody","orcid":"https://orcid.org/0000-0003-3680-3270","observed_orcids":["https://orcid.org/0000-0003-3680-3270"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Brody","raw_affiliation_strings":["1Thomas Jefferson University, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson University, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"13_Supplement","first_page":"A71","last_page":"A71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pim-1","display_name":"PIM-1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.9210000038146973},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oxaliplatin-sensitivity","display_name":"oxaliplatin sensitivity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/folfirinox","display_name":"FOLFIRINOX","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.621999979019165},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C98175054","wikidata":"https://www.wikidata.org/wiki/Q18030550","display_name":"PIM1","level":4,"score":0.8977278470993042},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6212102174758911},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5268113613128662},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5213624238967896},{"id":"https://openalex.org/C117838200","wikidata":"https://www.wikidata.org/wiki/Q14592582","display_name":"Stress granule","level":5,"score":0.43783876299858093},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.42579081654548645},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.35726743936538696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30158478021621704},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27183347940444946},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.21303051710128784},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.1947113573551178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11394420266151428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1018378734588623},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.057749152183532715},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca2014-a71","doi":"https://doi.org/10.1158/1538-7445.panca2014-a71","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca2014-a71","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2285821532","https://openalex.org/W2217032169","https://openalex.org/W2561952893","https://openalex.org/W2522633900","https://openalex.org/W2791403577","https://openalex.org/W2210295044","https://openalex.org/W4244714530","https://openalex.org/W3082211913","https://openalex.org/W2561827851","https://openalex.org/W2408196705"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1,390],"ductal":[2],"adenocarcinoma":[3],"(PDA)":[4],"is":[5,76,131,175],"an":[6],"aggressive":[7],"malignancy":[8],"characterized":[9],"by":[10,28,184,233,255,278,314,366],"its":[11,235],"insidious":[12],"development":[13],"and":[14,18,31,40,105,119,137,159,186,264,286,337,378,395],"resistance":[15,139],"to":[16,124,133,150,198,206,227,267,284],"conventional":[17],"targeted":[19],"therapies.":[20],"As":[21,182],"a":[22,38,52,93,207,223,244,335],"result":[23],"of":[24,55,113,129,156,164,169,173,190,215,251,276,290,311,332,340,362,384],"selective":[25,318],"pressures":[26],"imposed":[27],"cytotoxic":[29,63,268],"agents":[30,270],"the":[32,45,68,88,97,109,199,229,252,291,309,363,367,385],"tumor":[33,323],"microenvironment,":[34],"PDA":[35,56,116,147,202,217,260,281,341],"cells":[36,148,203,218,316],"orchestrate":[37],"potent":[39],"elusive":[41],"chemoresistant":[42],"mechanism.":[43],"Recently,":[44],"serine-threonine":[46],"kinase":[47],"PIM1":[48,72,89,130,157,174,241,333,365],"has":[49,305],"emerged":[50],"as":[51,334],"key":[53,288],"regulator":[54],"cell":[57,117,135,261,282,379],"survival":[58,118,136],"under":[59,101,140],"cancer-associated":[60],"stress":[61,142],"(e.g:":[62],"DNA-damaging":[64],"agents,":[65],"hypoxia).":[66],"However,":[67],"molecular":[69],"mechanism":[70],"behind":[71],"overexpression":[73],"in":[74,87,115,239,259,308,321,393],"PDAs":[75],"unknown.":[77],"Here,":[78],"we":[79,122,193,247],"demonstrate":[80,194,248],"that":[81,195,249,303],"cis-acting":[82],"AU-rich":[83],"elements":[84],"(ARE)":[85],"present":[86],"mRNA":[90,158,368],"3\u2019UTR":[91],"mediate":[92],"regulatory":[94],"interaction":[95],"with":[96,177,220,317],"mRNA-stability":[98],"factor":[99,370],"HuR":[100,114,165,179,196,230,256,277,304],"clinically":[102],"relevant":[103],"hypoxic":[104,208],"chemotherapeutic":[106,269],"stress.":[107],"Given":[108],"previously":[110],"described":[111],"role":[112],"therapeutic":[120,138,376],"response,":[121],"sought":[123],"determine":[125],"if":[126],"HuR-mediated":[127,171],"regulation":[128,214,331,361],"essential":[132],"promote":[134],"tumor-associated":[141],"(e.g.:":[143,271],"hypoxia,":[144],"chemotherapy).":[145],"Accordingly,":[146],"subjected":[149],"hypoxia":[151],"exhibit":[152],"dramatic":[153],"elevated":[154],"expression":[155],"protein.":[160],"Moreover,":[161],"siRNA-mediated":[162],"knockdown":[163,257],"abrogates":[166],"hypoxia-mediated":[167],"induction":[168],"PIM1.":[170],"stabilization":[172],"associated":[176],"high":[178],"cytoplasmic":[180],"expression.":[181,242],"revealed":[183],"immunofluorescence":[185],"western":[187],"blot":[188],"analyses":[189],"fractionated":[191],"lysates,":[192],"translocates":[197],"cytoplasm":[200],"when":[201],"are":[204],"exposed":[205],"microenvironment.":[209],"To":[210],"further":[211],"ascertain":[212],"HuR\u2019s":[213,330],"PIM1,":[216],"treated":[219],"MS-444":[221,279],"(Novartis),":[222],"small":[224],"molecule":[225],"known":[226],"disrupt":[228],"mRNA-stabilizing":[231],"activity":[232],"inhibiting":[234],"nuclear":[236],"export,":[237],"results":[238,258,299],"attenuated":[240],"From":[243],"translational":[245],"standpoint,":[246],"disruption":[250],"HuR:PIM1":[253],"axis":[254],"growth":[262,319],"inhibition":[263,275],"restores":[265],"sensitivity":[266,283],"oxaliplatin).":[272],"Similarly,":[273],"pharmacological":[274],"enhances":[280],"oxaliplatin":[285],"5-Fluorouracil,":[287],"components":[289],"promising":[292],"combinatory":[293],"therapy":[294],"FOLFIRINOX.":[295],"Taken":[296],"together,":[297],"these":[298],"provide":[300],"continuing":[301],"evidence":[302],"pro-oncogenic":[306],"properties":[307],"context":[310],"pancreatic":[312,374],"cancer":[313,375],"enabling":[315],"advantages":[320],"stressful":[322],"microenvironment":[324],"niches.":[325],"Lastly,":[326],"our":[327],"studies":[328],"implicate":[329],"novel":[336],"targetable":[338],"hallmark":[339],"progression.":[342],"Citation":[343],"Format:":[344],"Fernando":[345],"F.":[346],"Blanco,":[347],"Nicole":[348],"Meisner-Kober,":[349],"Eric":[350],"Londin,":[351],"Isidore":[352],"Rigoutsos,":[353],"Jordan":[354],"Winter,":[355],"Charles":[356],"Yeo,":[357],"Jonathan":[358],"Brody.":[359],"Post-transcriptional":[360],"proto-oncogene":[364],"stability":[369],"HuR:":[371],"implications":[372],"for":[373],"response":[377],"survival.":[380],"[abstract].":[381],"In:":[382],"Proceedings":[383],"AACR":[386],"Special":[387],"Conference":[388],"on":[389],"Cancer:":[391],"Innovations":[392],"Research":[394],"Treatment;":[396],"May":[397],"18-21,":[398],"2014;":[399],"New":[400],"Orleans,":[401],"LA.":[402],"Philadelphia":[403],"(PA):":[404],"AACR;":[405],"Cancer":[406],"Res":[407],"2015;75(13":[408],"Suppl):Abstract":[409],"nr":[410],"A71.":[411]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}