{"id":"https://openalex.org/W1248955338","doi":null,"title":"Genetic predisposition to schizophrenia: what did we learn and what does the future hold?","display_name":"Genetic predisposition to schizophrenia: what did we learn and what does the future hold?","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W1248955338","mag":"1248955338","pmid":"https://pubmed.ncbi.nlm.nih.gov/22184188"},"language":"en","primary_location":{"id":"pmid:22184188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22184188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046032568","display_name":"Andrea Vereczkei","orcid":"https://orcid.org/0000-0001-6477-9306","observed_orcids":["https://orcid.org/0000-0001-6477-9306"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Andrea Vereczkei","raw_affiliation_strings":["Semmelweis Egyetem, Orvosi Vegytani, Molekul\u00e1ris Biol\u00f3giai \u00e9s Pathobiok\u00e9miai Int\u00e9zet, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis Egyetem, Orvosi Vegytani, Molekul\u00e1ris Biol\u00f3giai \u00e9s Pathobiok\u00e9miai Int\u00e9zet, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072879540","display_name":"K\u00e1roly Mirnics","orcid":"https://orcid.org/0000-0002-5521-0254","observed_orcids":["https://orcid.org/0000-0002-5521-0254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karoly Mirnics","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8839,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83814058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"13","issue":"4","first_page":"205","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9739999771118164},{"id":"https://openalex.org/keywords/susceptibility-genes","display_name":"susceptibility genes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.699999988079071},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/disc1","display_name":"DISC1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/dtnbp1","display_name":"DTNBP1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/rgs4","display_name":"RGS4","score":0.9860000014305115},{"id":"https://openalex.org/keywords/kcnh2","display_name":"KCNH2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":1.0},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7419999837875366},{"id":"https://openalex.org/keywords/small-effect-sizes","display_name":"small effect sizes","score":0.6370000243186951},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.32499998807907104},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.6309999823570251},{"id":"https://openalex.org/keywords/treatment-of-schizophrenia","display_name":"schizophrenia treatment","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C2777568134","wikidata":"https://www.wikidata.org/wiki/Q15321582","display_name":"DISC1","level":3,"score":0.8998044729232788},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7873541116714478},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.6081875562667847},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5940660834312439},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4926753640174866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4836529493331909},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.45718997716903687},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4206974506378174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.401790052652359},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2885661721229553},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2477537989616394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2309863269329071},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.15437239408493042},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22184188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22184188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology","raw_type":"Journal Article"},{"id":"mag:1248955338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22184188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7279195532","display_name":"Effects Of Environmental Challenges On Genetically Modified Interneuronal Subpopulations","funder_award_id":"R01MH067234","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8673116115","display_name":"Neuroimmune Changes in Schizophrenia","funder_award_id":"R01MH079299","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W120859331","https://openalex.org/W181125515","https://openalex.org/W1608208769","https://openalex.org/W1963673462","https://openalex.org/W1974992252","https://openalex.org/W1981819066","https://openalex.org/W1981925126","https://openalex.org/W1991503782","https://openalex.org/W1995540460","https://openalex.org/W2001657113","https://openalex.org/W2003171104","https://openalex.org/W2005848760","https://openalex.org/W2009999409","https://openalex.org/W2014596655","https://openalex.org/W2020237866","https://openalex.org/W2021977271","https://openalex.org/W2023171821","https://openalex.org/W2035590942","https://openalex.org/W2036146366","https://openalex.org/W2042325100","https://openalex.org/W2045090442","https://openalex.org/W2049409070","https://openalex.org/W2050081796","https://openalex.org/W2050161506","https://openalex.org/W2050787008","https://openalex.org/W2052502735","https://openalex.org/W2060365969","https://openalex.org/W2060585121","https://openalex.org/W2066635264","https://openalex.org/W2066860601","https://openalex.org/W2071090720","https://openalex.org/W2085778323","https://openalex.org/W2088451418","https://openalex.org/W2089843122","https://openalex.org/W2094769668","https://openalex.org/W2098597355","https://openalex.org/W2103693302","https://openalex.org/W2105527159","https://openalex.org/W2106785307","https://openalex.org/W2112007464","https://openalex.org/W2112655025","https://openalex.org/W2112810336","https://openalex.org/W2116805879","https://openalex.org/W2122413563","https://openalex.org/W2127205775","https://openalex.org/W2129673851","https://openalex.org/W2131871863","https://openalex.org/W2133957865","https://openalex.org/W2138222426","https://openalex.org/W2142244624","https://openalex.org/W2161641617","https://openalex.org/W2169100323","https://openalex.org/W2230640574","https://openalex.org/W2239579816","https://openalex.org/W2418368378"],"related_works":["https://openalex.org/W4385607079","https://openalex.org/W2080563390","https://openalex.org/W2147221474","https://openalex.org/W2041406567","https://openalex.org/W2152104057","https://openalex.org/W2064156794","https://openalex.org/W2088343449","https://openalex.org/W4298312365","https://openalex.org/W1971251333","https://openalex.org/W1549008366"],"abstract_inverted_index":{"Schizophrenia":[0],"is":[1],"a":[2,50,69],"complex,":[3],"devastating":[4],"brain":[5,58],"disorder":[6],"with":[7,92,139,154],"clear":[8],"genetic":[9,53,110,133,194],"and":[10,86,119,158,186,193,196,203],"environmental":[11,191],"contributions":[12],"to":[13,59,123,146,160,178],"the":[14,17,20,34,42,57,61,74,98,107,140,161,188],"emergence":[15],"of":[16,24,27,29,33,52,73,101,106,163,168,183,190],"disease.":[18],"In":[19,127],"last":[21],"several":[22],"decades":[23],"research":[25],"hundreds":[26],"millions":[28],"dollars":[30],"were":[31],"spent":[32],"elusive":[35],"search":[36],"for":[37],"schizophrenia":[38,75,89,169],"susceptibility":[39],"genes,":[40,90],"but":[41],"results":[43],"have":[44,48,112,145,177],"been":[45,113],"meager.":[46],"Researchers":[47],"identified":[49],"number":[51,72,94],"variants":[54,111],"that":[55,131,148],"predispose":[56],"developing":[60],"disease,":[62],"yet":[63],"alone":[64],"they":[65],"can":[66],"explain":[67],"only":[68],"very":[70],"small":[71],"occurrence.":[76],"Vulnerability":[77],"in":[78],"DISC1,":[79],"NRG1,":[80],"DTNBP1,":[81],"RGS4,":[82],"KCNH2,":[83],"COMT,":[84],"AKT1":[85],"other":[87],"putative":[88],"together":[91],"copy":[93],"variants,":[95],"leave":[96],"unexplained":[97],"vast":[99],"majority":[100],"diseased":[102],"cases.":[103],"Furthermore,":[104],"most":[105],"uncovered":[108],"disease-associated":[109],"inconsistently":[114],"replicated":[115],"across":[116],"multiple":[117],"cohorts":[118],"do":[120],"not":[121,136,171],"lead":[122],"altered":[124],"protein":[125],"structure.":[126],"summary,":[128],"we":[129,142,144],"argue":[130],"large-scale":[132],"studies":[134,182],"will":[135,176],"provide":[137],"us":[138],"answers":[141],"seek:":[143],"accept":[147],"there":[149],"are":[150,170],"no":[151],"schizophrenia-predisposing":[152],"genes":[153],"large":[155],"effect":[156],"sizes,":[157],"due":[159],"diversity":[162],"findings,":[164],"genetics-based":[165],"novel":[166],"therapies":[167],"realistic.":[172],"The":[173],"new":[174],"treatments":[175],"come":[179],"from":[180],"functional":[181],"intracellular":[184,204],"pathways":[185],"understanding":[187],"confluence":[189],"influences":[192],"predisposition,":[195],"their":[197],"combined":[198],"effects":[199],"on":[200],"developmental":[201],"mechanisms":[202],"cascades.":[205]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
