{"id":"https://openalex.org/W124646823","doi":"https://doi.org/10.4049/jimmunol.182.supp.41.38","title":"Differential expression of CD4+ TReg cell subpopulations among ovarian cancer patients following autologous MUC1-specific Th1 effector cell immunotherapy (41.38)","display_name":"Differential expression of CD4+ TReg cell subpopulations among ovarian cancer patients following autologous MUC1-specific Th1 effector cell immunotherapy (41.38)","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W124646823","doi":"https://doi.org/10.4049/jimmunol.182.supp.41.38","mag":"124646823"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.supp.41.38","doi":"https://doi.org/10.4049/jimmunol.182.supp.41.38","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.41.38","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054601838","display_name":"Mark J. Dobrzanski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J Dobrzanski","raw_affiliation_strings":["1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109800510","display_name":"Kathleen Rewers\u2010Felkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Rewers-Felkins","raw_affiliation_strings":["1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080373869","display_name":"Khaliquzzaman A. Samad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.A. Samad","raw_affiliation_strings":["1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I4210130556","display_name":"Harrington Cancer Center","ror":"https://ror.org/03ak9f780","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Robinson","raw_affiliation_strings":["1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas","2Harrington Cancer Center, Amarillo, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"2Harrington Cancer Center, Amarillo, Texas","institution_ids":["https://openalex.org/I4210130556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007249471","display_name":"Stephen E. Wright","orcid":"https://orcid.org/0000-0002-7011-0606","observed_orcids":["https://orcid.org/0000-0002-7011-0606"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I4210129962","display_name":"Amarillo VA Health Care System","ror":"https://ror.org/034c6s521","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210129962","https://openalex.org/I4210144023"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen E Wright","raw_affiliation_strings":["1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas","3Amarillo Veterans Affairs Medical Center, Amarillo, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dept of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"3Amarillo Veterans Affairs Medical Center, Amarillo, Texas","institution_ids":["https://openalex.org/I4210129962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"1_Supplement","first_page":"41.38","last_page":"41.38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.1031000018119812,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":1.0},{"id":"https://openalex.org/keywords/cd45ro-t-cells","display_name":"CD45RO+ memory T cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cd45ra-naive-t-cells","display_name":"CD45RA+ naive T cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ccr1","display_name":"CCR1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.7739999890327454},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6587772965431213},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.636161744594574},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6225895285606384},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5750902891159058},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5291571617126465},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5282884240150452},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.46807965636253357},{"id":"https://openalex.org/C2777367678","wikidata":"https://www.wikidata.org/wiki/Q2304808","display_name":"Memory T cell","level":4,"score":0.45182037353515625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44894173741340637},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4330308437347412},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4247053265571594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35309070348739624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30037009716033936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27852463722229004}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.182.supp.41.38","doi":"https://doi.org/10.4049/jimmunol.182.supp.41.38","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.41.38","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082995909","https://openalex.org/W46646425","https://openalex.org/W2090592826","https://openalex.org/W4313353135","https://openalex.org/W4392377776","https://openalex.org/W2326957724","https://openalex.org/W2130201220","https://openalex.org/W2097101393","https://openalex.org/W2143000924","https://openalex.org/W2333277202"],"abstract_inverted_index":{"Abstract":[0],"Adoptive":[1],"T":[2,20,63,70,129,147,159,170,209],"cell":[3,53,64,71,148,171,195,210],"immunotherapy":[4,181],"is":[5],"a":[6],"viable":[7],"treatment":[8,60],"for":[9,48],"cancer":[10,205],"patients":[11,39,107,152,206],"and":[12,46,66,84,105,125,138,164,173],"optimally":[13],"requires":[14],"participation":[15],"of":[16,28,62,121,136,156,192],"Ag":[17],"specific":[18,158],"CD4":[19],"cells.":[21,130],"Here,":[22],"we":[23,55],"assessed":[24],"the":[25,162],"therapeutic":[26],"effects":[27],"adoptively":[29],"transferred":[30],"autologous":[31,183],"MUC1":[32,44,157,184],"peptide":[33,45],"stimulated":[34],"CD4+":[35,186],"effector":[36,52,187],"cells":[37,132,160,188],"in":[38,142,203],"with":[40,77,100,169,182],"ovarian":[41,204],"cancer.":[42],"Using":[43],"IL-2":[47],"ex":[49],"vivo":[50],"CD4+/Th1":[51],"generation,":[54],"show":[56],"that":[57,75,140,179,197],"3":[58],"monthly":[59],"cycles":[61],"restimulation":[65],"intraperitoneal":[67],"re-infusion":[68],"modulated":[69],"mediated":[72],"immune":[73],"responses":[74],"correlated":[76],"diminished":[78],"serum":[79],"CA125":[80],"tumor":[81,201],"marker":[82],"levels":[83,120,135,155,191],"enhanced":[85],"patient":[86,89,96],"survival.":[87],"One":[88],"survived":[90,97],"long":[91,98,199],"term":[92,99,116,200],"(>5":[93,103],"yrs),":[94],"another":[95],"recurrent":[101],"disease":[102],"yrs)":[104],"two":[106],"expired":[108],"within":[109],"100":[110],"days":[111],"following":[112,207],"final":[113],"infusion.":[114],"Long":[115],"survivors":[117],"showed":[118,153],"elevated":[119,154],"systemic":[122,144,193],"memory":[123,146],"(CD45RO)":[124],"nai\u0308ve":[126],"(CD45RA)":[127],"CD3/CD4/CD25+":[128],"Such":[131],"co-expressed":[133],"different":[134],"Foxp3":[137],"CTLA-4":[139],"resulted":[141],"lower":[143],"Foxp3/CTLA-4":[145],"ratios.":[149],"Lastly,":[150],"these":[151],"expressing":[161],"CCR5":[163],"CCR1":[165],"chemokine":[166],"receptors":[167],"associated":[168],"differentiation":[172],"select":[174],"migration.":[175],"This":[176],"data":[177],"suggests":[178],"effective":[180],"peptide-stimulated":[185],"induce":[189],"differential":[190],"TReg":[194],"subpopulations":[196],"influence":[198],"immunity":[202],"adoptive":[208],"transfer.":[211]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
