{"id":"https://openalex.org/W12390649","doi":null,"title":"IGFBP-2 at the interface of growth and metabolism--implications for childhood obesity.","display_name":"IGFBP-2 at the interface of growth and metabolism--implications for childhood obesity.","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W12390649","mag":"12390649","pmid":"https://pubmed.ncbi.nlm.nih.gov/21972778"},"language":"en","primary_location":{"id":"pmid:21972778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21972778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072393526","display_name":"Matthew A. Sabin","orcid":"https://orcid.org/0000-0002-1828-7404","observed_orcids":["https://orcid.org/0000-0002-1828-7404"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew A Sabin","raw_affiliation_strings":["Centre for Hormone Research and Department of Endocrinology & Diabetes Murdoch Childrens Research Institute, Royal Children's Hospital and University of Melbourne, Victoria, Australia. matt.sabin@rch.org.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Hormone Research and Department of Endocrinology & Diabetes Murdoch Childrens Research Institute, Royal Children's Hospital and University of Melbourne, Victoria, Australia. matt.sabin@rch.org.au","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vincenzo C Russo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincenzo C Russo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016518307","display_name":"Walid J. Azar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walid J Azar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072238018","display_name":"Steven W. Yau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven W Yau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044869014","display_name":"Wieland Kie\u00df","orcid":"https://orcid.org/0000-0003-4118-9455","observed_orcids":["https://orcid.org/0000-0003-4118-9455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wieland Kiess","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114006798","display_name":"George Arthur Werther","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George A Werther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6433,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.82030276,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"4","first_page":"382","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8190000057220459},{"id":"https://openalex.org/keywords/growth-hormone-igf-1-axis","display_name":"growth hormone/IGF-1 axis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.9380000233650208},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.847000002861023},{"id":"https://openalex.org/keywords/igf-i-bioavailability","display_name":"IGF-I bioavailability","score":0.8209999799728394},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/obesity-related-comorbidities","display_name":"obesity-related comorbidities","score":0.6959999799728394},{"id":"https://openalex.org/keywords/obesity-prevention","display_name":"obesity prevention","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.7216305732727051},{"id":"https://openalex.org/C2779422640","wikidata":"https://www.wikidata.org/wiki/Q3241451","display_name":"Childhood obesity","level":4,"score":0.6449205279350281},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5530003905296326},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4832799732685089},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.477411150932312},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.42035791277885437},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4198130965232849},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.41408324241638184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41372743248939514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3866938054561615},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3215041160583496},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14938175678253174},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.08679518103599548}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002657","descriptor_name":"Child Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21972778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21972778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Journal Article"},{"id":"mag:12390649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21972778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2609040313","https://openalex.org/W3177528932","https://openalex.org/W3005859061","https://openalex.org/W2283187206","https://openalex.org/W1965052557","https://openalex.org/W1988656729","https://openalex.org/W2898600258","https://openalex.org/W2042517750","https://openalex.org/W2077561525","https://openalex.org/W2053500047"],"abstract_inverted_index":{"The":[0],"growth":[1,3,119],"hormone/insulin-like":[2],"factor-I":[4],"(IGF-I)":[5],"axis":[6],"is":[7,61,92,100,109,124],"at":[8],"the":[9,93,102,136,158,163,176,192,203],"centre":[10],"of":[11,28,130,165,191,194,207],"normal":[12],"human":[13],"childhood":[14,208],"growth.":[15],"Six":[16],"well":[17],"characterised":[18],"binding":[19,51],"proteins":[20,52],"(IGFBP-1":[21],"to":[22,49,112,200],"IGFBP-6)":[23],"act":[24,113],"as":[25,114],"general":[26],"carriers":[27],"IGF-I,":[29],"but":[30,135],"they":[31],"also":[32,47,101],"modulate":[33],"IGF-I":[34],"bioavailability":[35],"and":[36,41,70,79,99,120,133,167,180,205],"activity":[37],"in":[38,58,77,84,97,157,196,202],"a":[39,115,183],"tissue-specific,":[40],"developmentally":[42],"appropriate,":[43],"manner.":[44],"Recent":[45],"findings":[46],"point":[48],"several":[50],"possessing":[53],"specific":[54],"'lGF-independent'":[55],"actions":[56],"and,":[57],"particular,":[59],"there":[60],"now":[62],"substantial":[63],"evidence":[64],"linking":[65],"IGFBP-2":[66,73,91,152,179,195],"with":[67,86,126,182],"nutritional":[68],"status":[69],"insulin":[71],"sensitivity.":[72],"concentrations":[74],"are":[75,82,148],"reduced":[76],"obesity,":[78],"further":[80],"reductions":[81],"seen":[83],"those":[85],"Type":[87],"2":[88],"diabetes.":[89],"As":[90],"major":[94],"IGFBP":[95,104],"expressed":[96],"infancy,":[98],"predominant":[103],"produced":[105],"from":[106],"adipocytes,":[107],"it":[108],"ideally":[110],"positioned":[111],"keystone":[116],"between":[117,178],"nutrition,":[118],"metabolism.":[121],"Childhood":[122],"obesity":[123,166,181],"associated":[125],"an":[127,188],"increased":[128,189],"risk":[129],"long-term":[131,146],"morbidity":[132],"mortality,":[134],"factors":[137],"that":[138,161],"determine":[139],"which":[140],"obese":[141],"children":[142],"will":[143],"develop":[144],"these":[145],"complications":[147],"not":[149],"fully":[150],"understood.":[151],"may":[153,198],"be":[154],"integrally":[155],"involved":[156],"molecular":[159],"processes":[160],"govern":[162],"development":[164],"subsequent":[168],"weight-related":[169],"disease.":[170],"Within":[171],"this":[172],"manuscript,":[173],"we":[174],"explore":[175],"associations":[177],"particular":[184],"emphasis":[185],"on":[186],"how":[187],"understanding":[190],"role":[193],"metabolism":[197],"lead":[199],"improvements":[201],"prevention":[204],"treatment":[206],"obesity.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}