{"id":"https://openalex.org/W123669970","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.12","title":"Peak force controls intracellular signaling after high force contractions, independent of metabolic stress","display_name":"Peak force controls intracellular signaling after high force contractions, independent of metabolic stress","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W123669970","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.12","mag":"123669970"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.801.12","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.801.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049939922","display_name":"Jill A. Rahnert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill A Rahnert","raw_affiliation_strings":["Applied Physiology Georgia Institute of Technology Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology Georgia Institute of Technology Atlanta GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060575550","display_name":"Thomas J. Burkholder","orcid":"https://orcid.org/0000-0001-8829-6587","observed_orcids":["https://orcid.org/0000-0001-8829-6587"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J Burkholder","raw_affiliation_strings":["Applied Physiology Georgia Institute of Technology Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology Georgia Institute of Technology Atlanta GA","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130701444"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01143077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peak-force","display_name":"peak force","score":0.6690000295639038},{"id":"https://openalex.org/keywords/mechanical-stress","display_name":"mechanical stress","score":0.8479999899864197},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.9919999837875366},{"id":"https://openalex.org/keywords/high-duty-cycle","display_name":"high duty cycle","score":0.6899999976158142},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.703000009059906},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.6779999732971191},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.5839999914169312},{"id":"https://openalex.org/keywords/acc-phosphorylation","display_name":"ACC phosphorylation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.7450000047683716},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9200000166893005},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.8640000224113464},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.796999990940094},{"id":"https://openalex.org/keywords/tibialis-anterior","display_name":"tibialis anterior","score":0.8360000252723694},{"id":"https://openalex.org/keywords/isometric-contraction","display_name":"isometric contraction","score":0.6840000152587891},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7137080430984497},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.679584801197052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5551997423171997},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48752424120903015},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4862307608127594},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.48344525694847107},{"id":"https://openalex.org/C199822604","wikidata":"https://www.wikidata.org/wiki/Q557120","display_name":"Duty cycle","level":3,"score":0.4659009873867035},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45028218626976013},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41944634914398193},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41641974449157715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4099087417125702},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35062354803085327},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.34501153230667114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2988337576389313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23913273215293884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21446141600608826},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.801.12","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.801.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3173265862","https://openalex.org/W2513946038","https://openalex.org/W2039295135","https://openalex.org/W3175051317","https://openalex.org/W1981700655","https://openalex.org/W2075728396","https://openalex.org/W2945880639","https://openalex.org/W1907890628","https://openalex.org/W2478085780","https://openalex.org/W2134384355"],"abstract_inverted_index":{"The":[0],"increase":[1],"in":[2,118,138,167],"protein":[3,131],"synthesis":[4],"following":[5],"resistance":[6],"exercise":[7],"has":[8],"been":[9],"attributed":[10],"to":[11,23,87,179],"the":[12,119,139,168,176,190],"high":[13,40,180],"forces":[14,101],"generated,":[15],"and":[16,29,34,77,95,109,153],"activation":[17],"of":[18,126,129,144,149,163],"several":[19],"signaling":[20,52,64],"cascades":[21],"appears":[22],"be":[24],"force":[25,181],"dependent.":[26],"Both":[27],"mechanical":[28,55,187],"metabolic":[30,59,68,198],"stresses":[31],"are":[32],"present,":[33],"ATP":[35],"depletion":[36],"is":[37,183,195],"aggravated":[38],"by":[39,70,97,197,201],"duty":[41,73],"cycle":[42,74],"(HDC)":[43],"protocols":[44],"(i.e.":[45],"30%":[46],"work:rest).":[47],"We":[48,173],"hypothesized":[49],"that":[50,175,192],"contraction\u2010induced":[51],"may":[53],"reflect":[54],"stress":[56,62,69,188],"more":[57],"than":[58,122,170],"stress.":[60,199],"Mechanical":[61],"induced":[63],"was":[65,116,135,165],"discriminated":[66],"from":[67],"using":[71],"low":[72],"(LDC,":[75],"2%)":[76],"HDC":[78,108,120,140,171],"(30%)":[79],"protocols.":[80],"Mouse":[81],"tibialis":[82],"anterior":[83],"muscles":[84],"were":[85,102],"subjected":[86],"60":[88],"maximal":[89],"isometric":[90],"activations":[91],"over":[92],"20":[93],"minutes":[94],"analyzed":[96],"Western":[98],"blot.":[99],"Peak":[100],"similar":[103],"(1.31":[104],"N":[105],"\u00b1":[106,111],"0.25,":[107],"1.22N":[110],"0.22,":[112],"LDC).":[113],"Force":[114,142],"decline":[115],"greater":[117,166],"(29%)":[121],"LDC":[123,169],"(3%).":[124],"Phosphorylation":[125,162],"ACC,":[127],"indicative":[128],"AMP\u2010activated":[130],"kinase":[132],"(AMPK)":[133],"activity,":[134],"markedly":[136],"increased":[137,151],"protocol.":[141,172],"generation":[143],"any":[145],"duration":[146],"reduced":[147,196],"phosphorylation":[148,194],"Akt,":[150],"ERK1/2,":[152],"had":[154],"no":[155],"effect":[156],"on":[157,186],"p70":[158],"s6k":[159],"or":[160],"4EBP1.":[161],"p38":[164,193],"conclude":[174],"immediate":[177],"response":[178],"contractions":[182],"largely":[184],"dependent":[185],"with":[189],"exception":[191],"Supported":[200],"DC05017":[202]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}