{"id":"https://openalex.org/W123340550","doi":null,"title":"Role of mesangial expansion in the pathogenesis of diabetic nephropathy.","display_name":"Role of mesangial expansion in the pathogenesis of diabetic nephropathy.","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W123340550","mag":"123340550","pmid":"https://pubmed.ncbi.nlm.nih.gov/11798146"},"language":"en","primary_location":{"id":"pmid:11798146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11798146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nephrology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026178919","display_name":"Michele Dalla Vestra","orcid":"https://orcid.org/0009-0000-0667-6325","observed_orcids":["https://orcid.org/0009-0000-0667-6325"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Dalla Vestra","raw_affiliation_strings":["Department of Medical and Surgical Sciences, University of Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, University of Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018051294","display_name":"Alois Saller","orcid":"https://orcid.org/0000-0003-2131-8731","observed_orcids":["https://orcid.org/0000-0003-2131-8731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Saller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000783448","display_name":"Michael S. Mauer","orcid":"https://orcid.org/0000-0001-7301-9616","observed_orcids":["https://orcid.org/0000-0001-7301-9616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Mauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066210400","display_name":"Paola Fioretto","orcid":"https://orcid.org/0000-0003-3445-0387","observed_orcids":["https://orcid.org/0000-0003-3445-0387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Fioretto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4812,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.66878223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"14 Suppl 4","issue":null,"first_page":"S51","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mesangial-expansion","display_name":"mesangial expansion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/diabetic-glomerulopathy","display_name":"diabetic glomerulopathy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/glomerular-basement-membrane-thickening","display_name":"glomerular basement membrane thickening","score":0.9179999828338623},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9340000152587891},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.984000027179718},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tubulointerstitial-injury","display_name":"tubulointerstitial injury","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pancreas-transplantation","display_name":"pancreas transplantation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/normoglycemia","display_name":"normoglycemia","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.832354724407196},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.8060426712036133},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.699599027633667},{"id":"https://openalex.org/C2780199430","wikidata":"https://www.wikidata.org/wiki/Q3347169","display_name":"Glomerulopathy","level":4,"score":0.6758224964141846},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.6117931604385376},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.6019313335418701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5985583066940308},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5336032509803772},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5196703672409058},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5062112212181091},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.47390735149383545},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35738837718963623},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3126070499420166}],"mesh":[{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005920","descriptor_name":"Glomerular Mesangium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11798146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11798146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nephrology","raw_type":"Journal Article"},{"id":"pmh:oai:www.research.unipd.it:11577/1346806","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/1346806","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:123340550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11798146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W26589038","https://openalex.org/W2026207396","https://openalex.org/W136915243","https://openalex.org/W64125619","https://openalex.org/W1556772986","https://openalex.org/W2154517212","https://openalex.org/W2143580981","https://openalex.org/W2040187493","https://openalex.org/W7097898021","https://openalex.org/W2102825342"],"abstract_inverted_index":{"Glomerulopathy,":[0],"characterized":[1],"by":[2,229],"thickening":[3],"of":[4,44,68,210,242],"the":[5,14,33,48,66,197,208,240,243,247],"glomerular":[6,55,84,98,115,147,221,248],"basement":[7],"membrane":[8],"(GBM)":[9],"and":[10,36,59,70,143,189,239,255],"mesangial":[11,45,162,194],"expansion,":[12,46],"is":[13,47,61,164,196,233],"most":[15,198],"important":[16,199,253],"renal":[17,155,167],"structural":[18,49,99,200],"change":[19],"in":[20,32,78,89,120,123,158,180,186,190,216,220,237,246],"type":[21,79,90,95,124,159,181,187,191],"1":[22,91,182,188],"diabetic":[23,26,81,92,126,133,211],"patients":[24,112],"with":[25,54],"nephropathy.":[27],"Morphological":[28],"lesions":[29,85,209],"develop":[30],"concomitantly":[31],"arterioles,":[34],"tubules":[35],"interstitium.":[37],"Mesangial":[38],"fractional":[39],"volume":[40],"[Vv(mes/glom)],":[41],"an":[42],"estimate":[43],"parameter":[50],"that":[51],"best":[52],"correlates":[53],"filtration":[56],"rate":[57],"(GFR)":[58],"it":[60],"also":[62,75],"closely":[63],"related":[64,165],"to":[65,166],"presence":[67],"proteinuria":[69],"hypertension.":[71],"Diabetic":[72],"glomerulopathy":[73,212],"has":[74,131,139,150],"been":[76],"described":[77],"2":[80,96,125,160,192],"patients,":[82],"but":[83,170],"are":[86,176],"milder":[87],"than":[88,146,179],"patients.":[93],"In":[94],"diabetes":[97,161],"parameters":[100],"are,":[101],"on":[102],"average,":[103],"altered.":[104],"However,":[105],"despite":[106],"persistent":[107],"microalbuminuria":[108],"or":[109,149,152],"proteinuria,":[110],"several":[111],"have":[113,204,252],"normal":[114,151,154],"structure.":[116,156],"Renal":[117],"structure":[118,222],"is,":[119],"fact,":[121],"heterogeneous":[122],"patients:":[127],"only":[128],"a":[129,136,234],"subset":[130],"typical":[132],"glomerulopathy,":[134],"while":[135],"substantial":[137],"proportion":[138],"more":[140],"advanced":[141],"tubulo-interstitial":[142],"vascular":[144],"rather":[145],"lesions,":[148],"near":[153],"Also":[157],"expansion":[163,195],"functional":[168],"parameters,":[169],"although":[171],"significant,":[172],"these":[173],"structural-functional":[174],"relationships":[175],"less":[177],"precise":[178],"diabetes.":[183],"Thus,":[184],"both":[185],"diabetes,":[193],"change.":[201],"Finally,":[202],"we":[203],"recently":[205],"demonstrated":[206],"that,":[207],"can":[213],"be":[214],"reversed":[215],"humans.":[217],"This":[218,232],"amelioration":[219],"was":[223],"observed":[224],"after":[225],"long-term":[226],"normoglycemia":[227],"obtained":[228],"pancreas":[230],"transplantation.":[231],"new":[235],"concept":[236],"nephrology,":[238],"understanding":[241],"mechanisms":[244],"involved":[245],"architectural":[249],"remodelling":[250],"might":[251],"clinical":[254],"therapeutic":[256],"implications.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
