{"id":"https://openalex.org/W123235284","doi":null,"title":"Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration.","display_name":"Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration.","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W123235284","mag":"123235284","pmid":"https://pubmed.ncbi.nlm.nih.gov/2108592"},"language":"en","primary_location":{"id":"pmid:2108592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2108592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of allergy","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054888070","display_name":"Roberto Paganelli","orcid":"https://orcid.org/0000-0003-3467-9317","observed_orcids":["https://orcid.org/0000-0003-3467-9317"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Paganelli","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, University La Sapienza, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, University La Sapienza, Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067965608","display_name":"Umberto Fagiolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Fagiolo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049968923","display_name":"Mauro Cancian","orcid":"https://orcid.org/0000-0003-2246-9144","observed_orcids":["https://orcid.org/0000-0003-2246-9144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Cancian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112627809","display_name":"G.C. Sturniolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G C Sturniolo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070970956","display_name":"Enrico Scala","orcid":"https://orcid.org/0000-0002-9391-9168","observed_orcids":["https://orcid.org/0000-0002-9391-9168","https://orcid.org/0000-0003-3904-3465"]},"institutions":[{"id":"https://openalex.org/I4210116004","display_name":"Istituto Dermopatico dell'Immacolata","ror":"https://ror.org/02b5mfy68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210116004","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Scala","raw_affiliation_strings":["Istituto Dermopatico dell'Immacolata , IDI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Dermopatico dell'Immacolata , IDI","institution_ids":["https://openalex.org/I4210116004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011333998","display_name":"Gianpiero D\u2019Offizi","orcid":"https://orcid.org/0000-0002-0091-3585","observed_orcids":["https://orcid.org/0000-0002-0091-3585"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G P D'Offizi","raw_affiliation_strings":["Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","institution_ids":["https://openalex.org/I4210091493"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4137,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.80648019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"64","issue":"4","first_page":"377","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":1.0},{"id":"https://openalex.org/keywords/sodium-cromoglycate","display_name":"disodium cromoglycate","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hypoallergenic-diet","display_name":"hypoallergenic diet","score":0.8899999856948853},{"id":"https://openalex.org/keywords/food-intolerance","display_name":"food intolerance","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cow-s-milk","display_name":"cow's milk","score":0.5730000138282776},{"id":"https://openalex.org/keywords/beta-lactoglobulin","display_name":"\u03b2-lactoglobulin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/serum-ige","display_name":"serum IgE","score":0.9570000171661377},{"id":"https://openalex.org/keywords/food-allergy","display_name":"food allergy","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2780717550","wikidata":"https://www.wikidata.org/wiki/Q540834","display_name":"Hypoallergenic","level":4,"score":0.9551595449447632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9217574000358582},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8281409740447998},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.7770423889160156},{"id":"https://openalex.org/C2909060570","wikidata":"https://www.wikidata.org/wiki/Q416427","display_name":"Disodium cromoglycate","level":3,"score":0.6730917692184448},{"id":"https://openalex.org/C2909531985","wikidata":"https://www.wikidata.org/wiki/Q416427","display_name":"Sodium cromoglycate","level":3,"score":0.5913580060005188},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5523428320884705},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.522057056427002},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5069034695625305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5046612024307251},{"id":"https://openalex.org/C2780661616","wikidata":"https://www.wikidata.org/wiki/Q17010342","display_name":"Elimination diet","level":4,"score":0.4717990458011627},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3943708837032318},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3641888499259949},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.24343690276145935},{"id":"https://openalex.org/C2776027960","wikidata":"https://www.wikidata.org/wiki/Q769815","display_name":"Food allergy","level":3,"score":0.17332687973976135},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.09963440895080566},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09452447295188904}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003109","descriptor_name":"Colonic Diseases, Functional","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004205","descriptor_name":"Cromolyn Sodium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004205","descriptor_name":"Cromolyn Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007782","descriptor_name":"Lactoglobulins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2108592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2108592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of allergy","raw_type":"Journal Article"},{"id":"pmh:oai:www.research.unipd.it:11577/2512493","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2512493","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:123235284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2108592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044433005","https://openalex.org/W1976878493","https://openalex.org/W2414773982","https://openalex.org/W2412345102","https://openalex.org/W2062559600","https://openalex.org/W2412898080","https://openalex.org/W2407360944","https://openalex.org/W2015223374","https://openalex.org/W1965551406","https://openalex.org/W1967139826"],"abstract_inverted_index":{"We":[0],"studied":[1],"14":[2],"patients":[3,68,92,127],"with":[4,23,33,51,58,72,82],"irritable":[5],"bowel":[6],"syndrome":[7],"for":[8,61],"the":[9,113,132,135],"presence":[10],"of":[11,67,85],"increased":[12,39],"intestinal":[13],"permeability":[14],"to":[15,21,53,106,119],"food":[16],"antigens":[17],"and":[18,24,73,80],"their":[19],"responses":[20],"diet":[22,55,71,78,133],"without":[25,74],"disodium":[26,59,83],"cromoglycate.":[27],"After":[28],"a":[29,110],"standardized":[30],"oral":[31],"challenge":[32],"cow":[34],"milk,":[35],"serum":[36,95],"beta-lactoglobulin":[37],"was":[38],"above":[40],"control":[41],"values":[42],"in":[43,112],"three":[44],"patients.":[45],"This":[46],"finding":[47],"did":[48],"not":[49,124],"correlate":[50],"response":[52],"hypoallergenic":[54],"or":[56],"treatment":[57],"cromoglycate":[60,84],"3":[62],"weeks.":[63],"However":[64],"over":[65],"50%":[66],"improved":[69],"after":[70],"DSCG":[75],"(2/5":[76],"on":[77,131],"only":[79,90],"5/7":[81],"12":[86],"evaluable":[87],"cases).":[88],"Since":[89],"two":[91],"had":[93],"elevated":[94],"IgE":[96],"levels,":[97],"our":[98],"results":[99],"suggest":[100],"that":[101],"intolerance":[102],"rather":[103],"than":[104],"hypersensitivity":[105],"foods":[107],"may":[108],"play":[109],"role":[111],"disease.":[114],"The":[115],"tests":[116],"we":[117],"used":[118],"identify":[120],"immunologic":[121],"mechanisms":[122],"could":[123],"predict":[125],"which":[126],"would":[128],"do":[129],"better":[130],"and/or":[134],"drug.":[136]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
