{"id":"https://openalex.org/W122843331","doi":null,"title":"Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.","display_name":"Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.","publication_year":1991,"publication_date":"1991-10-01","ids":{"openalex":"https://openalex.org/W122843331","mag":"122843331","pmid":"https://pubmed.ncbi.nlm.nih.gov/1656762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886309"},"language":"en","primary_location":{"id":"pmid:1656762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1656762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1886309/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049309702","display_name":"Jorge Caama\u00f1o","orcid":"https://orcid.org/0000-0003-3530-7056","observed_orcids":["https://orcid.org/0000-0003-3530-7056"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Caamano","raw_affiliation_strings":["Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036665836","display_name":"Bruce Ruggeri","orcid":"https://orcid.org/0009-0002-0095-873X","observed_orcids":["https://orcid.org/0009-0002-0095-873X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Ruggeri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067435207","display_name":"Shigeru Momiki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Momiki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053115717","display_name":"A Sickler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sickler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083901242","display_name":"S Y Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Y Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070591384","display_name":"Andres J. Klein\u2013Szanto","orcid":"https://orcid.org/0000-0002-5533-9402","observed_orcids":["https://orcid.org/0000-0002-5533-9402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Klein-Szanto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7476,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96447113,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"139","issue":"4","first_page":"839","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8119999766349792},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lung-cancer-cell-lines","display_name":"lung cancer cell lines","score":0.8899999856948853},{"id":"https://openalex.org/keywords/p53-gene-deletion","display_name":"p53 gene deletion","score":0.8220000267028809},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5559999942779541},{"id":"https://openalex.org/keywords/p53-immunoreactivity","display_name":"p53 immunoreactivity","score":0.6069999933242798},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.5},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7070683836936951},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6958439350128174},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6632113456726074},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.6489427089691162},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6467140913009644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6179607510566711},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.535027027130127},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5143693685531616},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.511419951915741},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4945509135723114},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45610907673835754},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40846478939056396},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3343391418457031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2655993103981018},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2449163794517517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15087881684303284},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12280780076980591},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1656762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1656762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1886309","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1886309/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:122843331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1656762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886309","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1886309/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1938649462","display_name":"CARCINOGENESIS OF XENOTRANSPLANTED HUMAN EPITHELIA","funder_award_id":"R01CA044981","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G446502261","display_name":"TUMOR SUPPRESSOR GENES IN CHEMICALLY INDUCED SKIN TUMORS","funder_award_id":"R01CA053713","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W187096906","https://openalex.org/W242819591","https://openalex.org/W1507168437","https://openalex.org/W1545495395","https://openalex.org/W1568755077","https://openalex.org/W1952836109","https://openalex.org/W2001258296","https://openalex.org/W2001962665","https://openalex.org/W2014669590","https://openalex.org/W2035975217","https://openalex.org/W2040876807","https://openalex.org/W2054549064","https://openalex.org/W2057397700","https://openalex.org/W2085172497","https://openalex.org/W2105298270","https://openalex.org/W2121328511","https://openalex.org/W2134871100","https://openalex.org/W2139498321","https://openalex.org/W2163565167","https://openalex.org/W2166452296"],"related_works":["https://openalex.org/W1513820318","https://openalex.org/W2065730711","https://openalex.org/W2087230077","https://openalex.org/W2088020585","https://openalex.org/W1998854344","https://openalex.org/W7097874958","https://openalex.org/W2044561848","https://openalex.org/W2069040950","https://openalex.org/W123332762","https://openalex.org/W1989434331"],"abstract_inverted_index":{"Immunohistochemical":[0],"analysis":[1],"of":[2,11,20,31,46,53,65,72,82,87,97,108,144,188,196,222,247,274],"p53,":[3],"a":[4,18,29,240,272,281],"nuclear":[5],"protein":[6,189],"involved":[7],"in":[8,17,28,79,198,220,231,239,253,271],"the":[9,66,85,95,106,132,135,214,223,260],"development":[10],"numerous":[12],"human":[13],"tumors,":[14],"was":[15,90,103,168],"performed":[16],"series":[19],"50":[21],"primary":[22,254],"nonsmall":[23],"cell":[24,35,57,153,174],"lung":[25,33,49,275],"carcinomas":[26,58],"and":[27,43,51,78,122,166,172,178,218,277],"group":[30],"eight":[32,152],"carcinoma":[34],"lines.":[36],"Using":[37],"two":[38,143],"mouse":[39],"monoclonal":[40],"antibodies,":[41],"PAb1801":[42],"PAb421,":[44],"sixteen":[45],"thirty-five":[47],"(45.7%)":[48],"adenocarcinomas":[50,100,129],"seven":[52],"fifteen":[54],"(46.6%)":[55],"squamous":[56],"showed":[59,186,205],"marked-to-moderate":[60],"immunoreactivity.":[61],"In":[62,201],"fifty-six":[63],"percent":[64],"positive":[67,83,110,121,158,290],"tumors":[68,84,111,124,147,255,276],"more":[69,284],"than":[70,92,105],"40%":[71],"all":[73],"cells":[74,89],"were":[75,115,138,148,157,182],"p53":[76,98,109,120,139,149,224,241,266,291],"positive,":[77,140],"only":[80,142],"17%":[81],"percentage":[86],"immunostained":[88],"less":[91],"ten.":[93],"Although":[94,244],"number":[96,107],"negative":[99,123,242],"without":[101,112,256],"metastasis":[102],"larger":[104],"metastasis,":[113],"there":[114,279],"not":[116,183],"clear":[117],"differences":[118],"between":[119,164],"with":[125,228],"metastasis.":[126],"Furthermore,":[127],"six":[128,156],"that":[130,181,216,236,265,278],"infiltrated":[131],"pleura":[133],"and/or":[134],"thoracic":[136],"wall":[137],"whereas":[141],"these":[145],"invasive":[146],"negative.":[150],"From":[151],"lines":[154],"studied,":[155],"for":[159,283],"p53.":[160],"A":[161],"good":[162],"correlation":[163],"immunocytochemistry":[165],"immunoprecipitation":[167],"observed.":[169],"Two":[170],"tumorigenic":[171],"metastatic":[173],"lines,":[175],"Calu":[176,179,203],"1":[177,204],"6,":[180],"immunoreactive":[184],"also":[185],"lack":[187],"by":[190],"immunoprecipitation,":[191],"as":[192,194],"well":[193],"absence":[195],"mRNA":[197],"Northern":[199],"analysis.":[200],"addition,":[202],"an":[206,232],"important":[207],"gene":[208,225],"deletion.":[209],"These":[210],"observations":[211],"point":[212],"to":[213,288],"fact":[215],"deletions":[217],"alterations":[219],"transcription":[221],"could":[226],"coincide":[227],"or":[229],"eventuate":[230],"advanced":[233,285],"malignant":[234],"phenotype":[235],"nevertheless":[237],"results":[238,261],"immunostain.":[243,292],"this":[245],"type":[246],"change":[248],"cannot":[249],"be":[250,268],"detected":[251,269],"immunohistochemically":[252,270],"further":[257],"molecular":[258],"analysis,":[259],"presented":[262],"herein":[263],"indicate":[264],"can":[267],"majority":[273],"is":[280],"tendency":[282],"adenocarcinoma":[286],"stages":[287],"exhibit":[289]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
