{"id":"https://openalex.org/W122040353","doi":null,"title":"An intrinsic requirement for Smyd1 in mouse cardiac and skeletal muscle","display_name":"An intrinsic requirement for Smyd1 in mouse cardiac and skeletal muscle","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W122040353","mag":"122040353"},"language":"en","primary_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/3943","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/3943","pdf_url":"http://hdl.handle.net/2152/3943","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2152/3943","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035914567","display_name":"Tara L. Rasmussen","orcid":"https://orcid.org/0000-0003-0481-8734","observed_orcids":["https://orcid.org/0000-0003-0481-8734","https://orcid.org/0000-0002-7721-4918"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tara L. Rasmussen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0481-8734","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035914567"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smyd1","display_name":"SMYD1","score":1.0},{"id":"https://openalex.org/keywords/set-domain-methyltransferases","display_name":"SET domain methyltransferase","score":0.6399999856948853},{"id":"https://openalex.org/keywords/mynd-domain","display_name":"MYND domain","score":0.9639999866485596},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.7850000262260437},{"id":"https://openalex.org/keywords/skeletal-muscle-development","display_name":"skeletal muscle development","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cardiac-septation","display_name":"cardiac septation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.6819999814033508},{"id":"https://openalex.org/keywords/ventricular-development","display_name":"ventricular development","score":0.5609999895095825},{"id":"https://openalex.org/keywords/dhand","display_name":"dHAND","score":0.6420000195503235},{"id":"https://openalex.org/keywords/irx4","display_name":"IRX4","score":0.996999979019165},{"id":"https://openalex.org/keywords/e-box","display_name":"E-box","score":0.7110000252723694},{"id":"https://openalex.org/keywords/muscle-specific-gene-expression","display_name":"muscle-specific gene expression","score":0.5609999895095825},{"id":"https://openalex.org/keywords/conditional-knockout","display_name":"conditional knockout","score":0.7110000252723694},{"id":"https://openalex.org/keywords/muscle-degeneration","display_name":"muscle degeneration","score":0.5849999785423279},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7638075351715088},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.6065259575843811},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3978157341480255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39301344752311707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31064721941947937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30977484583854675}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositories.lib.utexas.edu:2152/3943","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/3943","pdf_url":"http://hdl.handle.net/2152/3943","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:122040353","doi":null,"is_oa":false,"landing_page_url":"https://repositories.lib.utexas.edu/bitstream/2152/3943/2/rasmussent00265.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/3943","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/3943","pdf_url":"http://hdl.handle.net/2152/3943","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W122040353.pdf","grobid_xml":"https://content.openalex.org/works/W122040353.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1516012212","https://openalex.org/W1593794388","https://openalex.org/W1966094020","https://openalex.org/W1966563415","https://openalex.org/W1966579467","https://openalex.org/W1967287827","https://openalex.org/W1969655939","https://openalex.org/W1971075145","https://openalex.org/W1971992148","https://openalex.org/W1972781320","https://openalex.org/W1973431915","https://openalex.org/W1974261580","https://openalex.org/W1974543599","https://openalex.org/W1978564046","https://openalex.org/W1984604208","https://openalex.org/W1991593808","https://openalex.org/W1993932431","https://openalex.org/W1994468513","https://openalex.org/W1995146375","https://openalex.org/W1996563085","https://openalex.org/W1998537251","https://openalex.org/W1999375912","https://openalex.org/W1999563094","https://openalex.org/W2002732720","https://openalex.org/W2011182719","https://openalex.org/W2017444651","https://openalex.org/W2020522024","https://openalex.org/W2025860724","https://openalex.org/W2027264255","https://openalex.org/W2030062212","https://openalex.org/W2033522367","https://openalex.org/W2033759169","https://openalex.org/W2037707993","https://openalex.org/W2038062572","https://openalex.org/W2038996595","https://openalex.org/W2040489034","https://openalex.org/W2045414766","https://openalex.org/W2050173039","https://openalex.org/W2051026229","https://openalex.org/W2051850259","https://openalex.org/W2058172887","https://openalex.org/W2059088759","https://openalex.org/W2059933961","https://openalex.org/W2063333928","https://openalex.org/W2066398820","https://openalex.org/W2068482643","https://openalex.org/W2068852923","https://openalex.org/W2073860278","https://openalex.org/W2078718449","https://openalex.org/W2078827811","https://openalex.org/W2080592158","https://openalex.org/W2087621054","https://openalex.org/W2087665886","https://openalex.org/W2093968919","https://openalex.org/W2095374278","https://openalex.org/W2095683716","https://openalex.org/W2106802219","https://openalex.org/W2109719547","https://openalex.org/W2111031333","https://openalex.org/W2111336754","https://openalex.org/W2114748673","https://openalex.org/W2116432506","https://openalex.org/W2123934552","https://openalex.org/W2126834790","https://openalex.org/W2128600629","https://openalex.org/W2129248963","https://openalex.org/W2129887005","https://openalex.org/W2132739672","https://openalex.org/W2135058118","https://openalex.org/W2137993259","https://openalex.org/W2147507695","https://openalex.org/W2148731673","https://openalex.org/W2148750342","https://openalex.org/W2150621532","https://openalex.org/W2152658552","https://openalex.org/W2153550523","https://openalex.org/W2160035613","https://openalex.org/W2166302161","https://openalex.org/W2166410110","https://openalex.org/W2166752218","https://openalex.org/W2335949992","https://openalex.org/W2470606780","https://openalex.org/W3109609690"],"related_works":["https://openalex.org/W2905017138","https://openalex.org/W3145489929","https://openalex.org/W2193543956","https://openalex.org/W2099022064","https://openalex.org/W2168027209","https://openalex.org/W3147244636","https://openalex.org/W2150418007","https://openalex.org/W6903671671","https://openalex.org/W1534165090","https://openalex.org/W1954753792"],"abstract_inverted_index":{"Smyd1":[0,16,39,51,114,205,230,238,260,283,302],"is":[1,40,115,129,141,206,284,323],"the":[2,71,108,165,176,179,186,189,193,203,257,263,275,321,328],"founder":[3],"of":[4,38,63,73,103,107,113,120,151,167,178,188,278,301],"a":[5,66,77,87,121,132,251,296,312,324,342],"gene":[6,194],"family":[7],"whose":[8],"members":[9],"contain":[10],"split":[11],"SET":[12,19],"and":[13,28,70,85,156,223,244,250,267,330,341],"MYND":[14,36],"Domains.":[15],"has":[17,306],"several":[18,279],"dependent":[20,142],"lysine":[21],"methyl-transferase":[22],"substrates,":[23],"including":[24,60],"multiple":[25],"histone":[26],"lysines":[27],"at":[29,54,192],"least":[30],"one":[31,100],"non-histone":[32],"protein,":[33],"skNAC.":[34,49],"The":[35],"domain":[37],"required":[41],"for":[42,81,210],"protein":[43],"interactions,":[44],"such":[45],"as":[46,315,317],"that":[47,97,175,256,268],"with":[48,311],"Conventional":[50],"knockouts":[52,270],"die":[53],"E10":[55],"due":[56,184,197],"to":[57,117,185,198],"cardiac":[58,64,211,216,226,248,289],"defects,":[59],"an":[61,98],"enrichment":[62],"jelly,":[65],"decrease":[67],"in":[68,123,224,274,308,320],"trabeculation,":[69,247],"loss":[72],"ventricular":[74,83],"septation.":[75],"dHand,":[76],"transcription":[78],"factor":[79],"specific":[80,89,110,127,299],"right":[82],"development,":[84,217,222],"Irx4,":[86],"ventricle":[88],"gene,":[90],"are":[91,233,241,293],"down":[92],"regulated.":[93],"I":[94,145,172,254],"have":[95,146,173,271],"shown":[96,174],"approximately":[99],"kb":[101],"stretch":[102,150],"DNA":[104],"sequence":[105,152],"upstream":[106],"muscle":[109,139,221,298,336],"first":[111],"exon":[112],"sufficient":[116],"drive":[118],"expression":[119,128,140,276],"reporter":[122],"transgenic":[124],"mice.":[125],"Cardiac":[126],"mediated":[130,169,259,303],"by":[131,304],"proximal":[133],"Mef2":[134],"binding":[135],"site":[136],"whereas":[137],"skeletal":[138,220,297,331],"on":[143,159,202],"E-boxes.":[144],"fully":[147],"analyzed":[148],"this":[149],"via":[153],"computational":[154],"methods":[155],"made":[157],"predictions":[158],"other":[160],"potential":[161],"regulatory":[162],"factors.":[163],"Through":[164],"use":[166],"Cre":[168],"conditional":[170],"knockouts,":[171,239],"phenotype":[177,314,322],"conventional":[180,237,265],"knockout":[181,266],"was":[182],"not":[183,207],"introduction":[187],"Neomycin":[190],"cassette":[191],"locus":[195],"or":[196],"cell":[199],"non-autonomous":[200],"effects":[201],"heart.":[204],"only":[208],"essential":[209],"septation,":[212],"but":[213,240],"throughout":[214],"embryonic":[215,219,231],"during":[218],"adult":[225,288],"tissue.":[227],"Conditionally":[228],"deficient":[229],"hearts":[232],"less":[234],"affected":[235],"than":[236],"embryonically":[242],"lethal":[243],"show":[245],"poor":[246],"hemorrhaging,":[249],"pericardial":[252],"edema.":[253],"detail":[255],"Nkx2.5-Cre":[258],"deletion":[261],"phenocopies":[262],"skNAC":[264],"both":[269],"similar":[272],"changes":[273],"levels":[277],"genes.":[280],"Furthermore,":[281],"when":[282],"conditionally":[285],"removed":[286],"from":[287],"tissue,":[290],"survival":[291],"rates":[292],"diminished.":[294],"Surprisingly":[295],"CKO":[300],"Myogenin-Cre":[305],"resulted":[307],"perinatal":[309],"lethality,":[310],"visible":[313],"early":[316],"E15.":[318],"Evident":[319],"large":[325],"edema":[326],"between":[327],"epithelium":[329],"muscle,":[332],"fewer":[333],"myoblasts,":[334],"decreased":[335],"mass,":[337],"increased":[338],"degenerating":[339],"cells,":[340],"potentially":[343],"defective":[344],"differentiation":[345],"process.":[346]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}