{"id":"https://openalex.org/W121653993","doi":null,"title":"Aluminum-induced neurotoxicity and oxidative damage in rabbits: protective effect of melatonin.","display_name":"Aluminum-induced neurotoxicity and oxidative damage in rabbits: protective effect of melatonin.","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W121653993","mag":"121653993","pmid":"https://pubmed.ncbi.nlm.nih.gov/16264393"},"language":"en","primary_location":{"id":"pmid:16264393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16264393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053483364","display_name":"Sary Kh. Abd\u2010Elghaffar","orcid":"https://orcid.org/0000-0002-5956-8798","observed_orcids":["https://orcid.org/0000-0002-5956-8798"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sary Kh Abd-Elghaffar","raw_affiliation_strings":["Department of Pathology and Clinical Pathology, Faculty of Science, Assiut University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Clinical Pathology, Faculty of Science, Assiut University, Egypt","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109077273","display_name":"Gamal H. El\u2010Sokkary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gamal H El-Sokkary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030943272","display_name":"A. A. Sharkawy","orcid":"https://orcid.org/0000-0003-1462-321X","observed_orcids":["https://orcid.org/0000-0003-1462-321X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed A Sharkawy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9221,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.89758704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"26","issue":"5","first_page":"609","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aluminum-neurotoxicity","display_name":"aluminum neurotoxicity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/aluminum-chloride","display_name":"aluminum chloride","score":0.8799999952316284},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7419999837875366},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9760000109672546},{"id":"https://openalex.org/keywords/4-hydroxyalkenals","display_name":"4-hydroxyalkenals","score":0.9210000038146973},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6330000162124634},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.3930000066757202},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/neurofibrillary-degeneration","display_name":"neurofibrillary degeneration","score":0.9129999876022339},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.7950000166893005},{"id":"https://openalex.org/keywords/chronic-aluminum-exposure","display_name":"chronic aluminum exposure","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8570383787155151},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7234827280044556},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6939539909362793},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6686257123947144},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6540364027023315},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5995643138885498},{"id":"https://openalex.org/C2992339995","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Free radical scavenger","level":3,"score":0.5902215838432312},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5874823331832886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5868778228759766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5026018619537354},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5021030902862549},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.446732759475708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.280123233795166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2760353982448578},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.26912450790405273}],"mesh":[{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009454","descriptor_name":"Neurofibrils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16264393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16264393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:121653993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16264393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2912455234","https://openalex.org/W2025192037","https://openalex.org/W2136531204","https://openalex.org/W2887629392","https://openalex.org/W2933033304","https://openalex.org/W2060075238","https://openalex.org/W4360974277","https://openalex.org/W3095568060","https://openalex.org/W2910759233","https://openalex.org/W2181600100"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,26,138,215,257],"present":[2],"study":[3],"was":[4,135,185,237],"aimed":[5],"to":[6],"investigate:":[7],"(1)":[8],"the":[9,103,132,219,229,268,274,298,304],"neurotoxic":[10],"oxidative":[11,38],"damage":[12],"of":[13,28,161,174,212,221,228,259,264],"orally":[14],"administered":[15,80],"aluminum":[16,287,317],"chloride":[17],"(AlCl3)":[18],"in":[19,131,156,166,179,188,203,218,231,273,281,289,316],"rabbits":[20,44,290],"(Biochemical":[21],"and":[22,33,56,105,111,146,151,169,192,206,226,234,250,267,278,302],"morphopathological":[23,139,269,294],"studies).":[24],"(2)":[25],"effect":[27,312],"melatonin":[29,82,96],"as":[30,107,114,117,119,123,242,244,313],"an":[31,124,180,314],"antioxidant":[32,125,265,315],"free":[34],"radical":[35],"scavenger":[36],"on":[37],"neuropathic":[39],"changes.":[40],"METHODS:":[41],"Thirty-five":[42],"male":[43],"were":[45,127,141,153,254,271],"divided":[46],"into":[47],"4":[48],"groups":[49,167,189,204,277],"(A,":[50],"B,":[51],"C":[52,92,170,193,207],"[10":[53],"animals":[54,220],"each]":[55],"D":[57,101,198],"[5":[58],"animals]).":[59],"Group":[60,72,91,100],"A":[61,158,175,223],"received":[62,74,93,102],"AlCl3":[63,75,94],"(20":[64],"mg/l":[65],"via":[66],"drinking":[67],"water":[68],"for":[69,76,88,97],"3":[70,77,98],"months).":[71],"B":[73,168,191,205],"months":[78],"then":[79],"with":[81,172,196,210,239],"(10":[83],"mg/kg":[84],"b.w.":[85],"sc":[86],"daily":[87],"15":[89],"days).":[90],"plus":[95],"months.":[99],"solvent":[104],"served":[106],"control.":[108],"Malondialdehyde":[109],"(MDA)":[110],"4-hydroxyalkenals":[112],"(4-HDA)":[113],"lipid":[115,260,299],"peroxides":[116],"well":[118,243],"superoxide":[120],"dismutase":[121],"(SOD)":[122],"enzyme":[126],"measured.":[128],"Aluminum":[129,183],"residue":[130],"brain":[133],"tissue":[134],"measured":[136],"spectrophotometerically.":[137],"changes":[140,270],"also":[142,255],"examined":[143],"by":[144],"light":[145],"electron":[147],"microscopes.":[148],"RESULTS:":[149],"MDA":[150],"4-HAD":[152],"significantly":[154,164,186,201],"increased":[155,187],"group":[157,197,213,222,284],"versus":[159],"those":[160,173],"controls":[162],"while":[163,199],"decreased":[165,202],"compared":[171,195,209],"group.":[176],"SOD":[177,305],"run":[178],"opposite":[181],"manner.":[182],"concentration":[184],"A,":[190],"when":[194,208],"it":[200],"that":[211],"A.":[214],"neuropathlogical":[216],"examination":[217],"revealed":[224],"atrophy":[225],"apoptosis":[227],"neurons":[230],"cerebral":[232],"cortex":[233],"hippocampus.":[235],"This":[236],"associated":[238],"neurofibrillary":[240],"degeneration":[241,249],"argyrophilic":[245],"inclusion.":[246],"Schwan":[247],"cell":[248],"nerve":[251],"fiber":[252],"demylination":[253],"encountered.":[256],"elaboration":[258],"peroxidation":[261,300],"products,":[262],"inhibition":[263],"enzymes":[266],"minimized":[272],"Al/Mel":[275],"treated":[276,283],"markedly":[279],"improved":[280],"Al+Mel":[282],"CONCLUSION:":[285],"Chronic":[286],"exposure":[288],"had":[291,308],"dramatic":[292],"encephalopathic":[293],"lesions.":[295],"It":[296],"enhances":[297],"production":[301],"inhibits":[303],"enzyme.":[306],"Melatonin":[307],"a":[309],"good":[310],"prophylactic":[311],"encephalopathy.":[318]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}