{"id":"https://openalex.org/W12144253","doi":null,"title":"Nerve growth factor increases electrical activity of neural cells derived from murine bone marrow stromal cells.","display_name":"Nerve growth factor increases electrical activity of neural cells derived from murine bone marrow stromal cells.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W12144253","mag":"12144253","pmid":"https://pubmed.ncbi.nlm.nih.gov/22592198"},"language":"en","primary_location":{"id":"pmid:22592198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22592198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112078474","display_name":"Shigemasa Tomioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigemasa Tomioka","raw_affiliation_strings":["Department of Dental Anesthesiology, The University of Tokushima Graduate School, Kuramoto-cho, Tokushima City, Tokushima, Japan. tomioka@dent.tokushima-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Anesthesiology, The University of Tokushima Graduate School, Kuramoto-cho, Tokushima City, Tokushima, Japan. tomioka@dent.tokushima-u.ac.jp","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088033019","display_name":"Tatsumi Nagahama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsumi Nagahama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058976287","display_name":"Reiko Tokuyama-Toda","orcid":"https://orcid.org/0000-0003-3932-5913","observed_orcids":["https://orcid.org/0000-0003-3932-5913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reiko Tokuyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080516415","display_name":"Seiko Tatehara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seiko Tatehara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007374424","display_name":"Kazuhito Satomura","orcid":"https://orcid.org/0000-0003-2159-1279","observed_orcids":["https://orcid.org/0000-0003-2159-1279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhito Satomura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"33","issue":"2","first_page":"177","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.06379999965429306,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":1.0},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.652999997138977},{"id":"https://openalex.org/keywords/field-potentials","display_name":"field potentials","score":0.6690000295639038},{"id":"https://openalex.org/keywords/spontaneous-neuronal-activity","display_name":"spontaneous neuronal activity","score":0.6209999918937683},{"id":"https://openalex.org/keywords/neurofilaments","display_name":"neurofilaments","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/stem-cell-derived-neurons","display_name":"stem cell-derived neurons","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.7663894295692444},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.7024951577186584},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6830295324325562},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.6709170341491699},{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.6211509108543396},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5602622628211975},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5584368109703064},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5235571265220642},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.4960094392299652},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4476828873157501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43305566906929016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4092901945114136},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3990631103515625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38122880458831787},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23239707946777344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20621025562286377},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.18856185674667358},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06854230165481567}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22592198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22592198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:12144253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22592198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1625740378","https://openalex.org/W1980157636","https://openalex.org/W1982561969","https://openalex.org/W2005848913","https://openalex.org/W2041795834","https://openalex.org/W2048873465","https://openalex.org/W2070568755","https://openalex.org/W2078316783","https://openalex.org/W2089521317","https://openalex.org/W2094544368","https://openalex.org/W2094635970","https://openalex.org/W2129220462","https://openalex.org/W2130571779","https://openalex.org/W2133108418","https://openalex.org/W2169959603","https://openalex.org/W2324072678"],"related_works":["https://openalex.org/W2386402366","https://openalex.org/W2377794849","https://openalex.org/W3032844280","https://openalex.org/W2350049030","https://openalex.org/W2374333966","https://openalex.org/W2149651338","https://openalex.org/W2360349534","https://openalex.org/W2363466773","https://openalex.org/W2139273892","https://openalex.org/W2082018267"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Nerve":[1],"growth":[2],"factor":[3],"(NGF)":[4],"triggers":[5],"long-term":[6],"neuronal":[7,47,161],"excitability.":[8],"We":[9],"examined":[10,52],"its":[11],"effect":[12,178],"on":[13],"murine":[14,165],"bone":[15],"marrow":[16],"stromal":[17],"cells":[18,162],"(BMSC)-derived":[19],"neurons.":[20,189],"METHODS:":[21],"With":[22],"an":[23],"optimal":[24],"differentiation":[25,39],"protocol,":[26],"BMSCs":[27,166],"were":[28,66,97,121],"differentiated":[29],"into":[30,42],"neurons":[31,73,77,91],"in":[32],"culture.":[33],"To":[34,55],"confirm":[35],"the":[36,44,57,63,79,115,136,141,144,177],"probability":[37],"of":[38,40,46,60,107,117,138,143,146,179,187],"BMSC":[41],"neuron,":[43],"expression":[45],"marker":[48],"protein,":[49],"neurofilament,":[50],"was":[51,110],"by":[53,83],"immunocytochemistry.":[54],"examine":[56],"electrophysiological":[58],"properties":[59],"BMSC-derived":[61,72,76,90,113,188],"neurons,":[62,114],"field":[64,119,147,169],"potentials":[65,120,148],"recorded":[67],"either":[68],"from":[69,75,164],"nontreated":[70],"(control)":[71],"or":[74],"after":[78,127,153],"treatment":[80],"with":[81],"NGF":[82,103,128,154,175],"using":[84],"extracellular":[85],"recording":[86],"techniques.":[87],"RESULTS:":[88],"Most":[89],"showed":[92],"spontaneous":[93],"discharges":[94],"whose":[95],"amplitudes":[96,116,145],"up":[98],"to":[99,112],"2":[100],"mV.":[101],"When":[102],"at":[104],"a":[105],"concentration":[106],"100":[108],"ng/ml":[109],"applied":[111],"discrete":[118,168],"gradually":[122],"enlarged":[123],"within":[124],"1":[125],"min":[126,133,152],"application":[129],"and":[130,173],"peaked":[131],"3":[132],"later":[134],"(20-fold":[135],"size":[137],"control).":[139],"However,":[140],"enlargement":[142],"almost":[149],"disappeared":[150],"5":[151],"application.":[155],"CONCLUSION:":[156],"This":[157],"finding":[158],"indicates":[159],"that":[160,174],"derived":[163],"generate":[167],"potential":[170],"activities":[171],"spontaneously":[172],"has":[176],"enlarging":[180],"transient,":[181],"but":[182],"not":[183],"sustained,":[184],"electrical":[185],"activity":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}