{"id":"https://openalex.org/W1210371011","doi":null,"title":"Autophagy in pancreatic cancer pathogenesis and treatment.","display_name":"Autophagy in pancreatic cancer pathogenesis and treatment.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1210371011","mag":"1210371011","pmid":"https://pubmed.ncbi.nlm.nih.gov/22860230","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410583"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2416504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410583","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091664811","display_name":"Rui Kang","orcid":"https://orcid.org/0000-0003-2725-1574","observed_orcids":["https://orcid.org/0000-0003-2725-1574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055468442","display_name":"Daolin Tang","orcid":"https://orcid.org/0000-0002-1903-6180","observed_orcids":["https://orcid.org/0000-0002-1903-6180","https://orcid.org/0000-0002-2650-3816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daolin Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0368,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.91713061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"4","first_page":"383","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0},{"id":"https://openalex.org/keywords/autophagy-inhibition","display_name":"autophagy inhibition","score":0.7239999771118164},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8809999823570251},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7739999890327454},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cancer-risk-factors","display_name":"cancer risk factors","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9464881420135498},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8672080039978027},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.637820303440094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5225557684898376},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.46800342202186584},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4587765634059906},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4465055465698242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42561012506484985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41674309968948364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2028159499168396},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08343279361724854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2416504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3410583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410583","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:22860230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22860230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:1210371011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22860230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2416504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W1494422399","https://openalex.org/W1526836724","https://openalex.org/W1565276921","https://openalex.org/W1784425676","https://openalex.org/W1861728615","https://openalex.org/W1940833972","https://openalex.org/W1964565569","https://openalex.org/W1965045013","https://openalex.org/W1965751594","https://openalex.org/W1965827991","https://openalex.org/W1965887568","https://openalex.org/W1969305254","https://openalex.org/W1969587176","https://openalex.org/W1970048838","https://openalex.org/W1972553173","https://openalex.org/W1976284083","https://openalex.org/W1979342940","https://openalex.org/W1987695408","https://openalex.org/W1989038389","https://openalex.org/W1989051519","https://openalex.org/W1989443548","https://openalex.org/W1991210241","https://openalex.org/W1991222141","https://openalex.org/W1993643473","https://openalex.org/W1994184760","https://openalex.org/W1994823455","https://openalex.org/W1994863868","https://openalex.org/W1995571717","https://openalex.org/W1995966034","https://openalex.org/W1996326339","https://openalex.org/W1996593753","https://openalex.org/W1998192361","https://openalex.org/W1999801453","https://openalex.org/W2002636911","https://openalex.org/W2006201075","https://openalex.org/W2006937936","https://openalex.org/W2007193116","https://openalex.org/W2016040396","https://openalex.org/W2017280299","https://openalex.org/W2018652887","https://openalex.org/W2018653121","https://openalex.org/W2019859798","https://openalex.org/W2022101765","https://openalex.org/W2022570265","https://openalex.org/W2025364264","https://openalex.org/W2025665129","https://openalex.org/W2028536701","https://openalex.org/W2030287946","https://openalex.org/W2031169909","https://openalex.org/W2034132952","https://openalex.org/W2034893372","https://openalex.org/W2038976751","https://openalex.org/W2039607936","https://openalex.org/W2043724674","https://openalex.org/W2045316920","https://openalex.org/W2049413898","https://openalex.org/W2049477763","https://openalex.org/W2050985569","https://openalex.org/W2052094075","https://openalex.org/W2057274775","https://openalex.org/W2058170782","https://openalex.org/W2058270730","https://openalex.org/W2059637124","https://openalex.org/W2059718338","https://openalex.org/W2059809983","https://openalex.org/W2059999514","https://openalex.org/W2063096082","https://openalex.org/W2064903115","https://openalex.org/W2068051463","https://openalex.org/W2068862752","https://openalex.org/W2072358066","https://openalex.org/W2076526469","https://openalex.org/W2078893058","https://openalex.org/W2079286948","https://openalex.org/W2079605616","https://openalex.org/W2081057817","https://openalex.org/W2084760624","https://openalex.org/W2084946596","https://openalex.org/W2087510837","https://openalex.org/W2089039955","https://openalex.org/W2089074573","https://openalex.org/W2090283980","https://openalex.org/W2090748725","https://openalex.org/W2092321143","https://openalex.org/W2096308078","https://openalex.org/W2097259163","https://openalex.org/W2098082928","https://openalex.org/W2099297070","https://openalex.org/W2101228747","https://openalex.org/W2102690338","https://openalex.org/W2104416279","https://openalex.org/W2106949373","https://openalex.org/W2108086395","https://openalex.org/W2108404067","https://openalex.org/W2109034822","https://openalex.org/W2114242405","https://openalex.org/W2115408859","https://openalex.org/W2116602759","https://openalex.org/W2117945272","https://openalex.org/W2122065834","https://openalex.org/W2124331048","https://openalex.org/W2131070390","https://openalex.org/W2133000461","https://openalex.org/W2134627852","https://openalex.org/W2138951620","https://openalex.org/W2142253011","https://openalex.org/W2143070222","https://openalex.org/W2144814745","https://openalex.org/W2145037638","https://openalex.org/W2145206598","https://openalex.org/W2150027419","https://openalex.org/W2152518226","https://openalex.org/W2154846778","https://openalex.org/W2157096314","https://openalex.org/W2157320227","https://openalex.org/W2157429299","https://openalex.org/W2157699677","https://openalex.org/W2158535498","https://openalex.org/W2159042370","https://openalex.org/W2161050915","https://openalex.org/W2162800502","https://openalex.org/W2163351331","https://openalex.org/W2166653998","https://openalex.org/W2169590959","https://openalex.org/W2189588709","https://openalex.org/W2318156113","https://openalex.org/W2480328579","https://openalex.org/W3134530972","https://openalex.org/W7097574187"],"related_works":["https://openalex.org/W3184378144","https://openalex.org/W2102690338","https://openalex.org/W4286005638","https://openalex.org/W4283209502","https://openalex.org/W3100498958","https://openalex.org/W3018428148","https://openalex.org/W3209715423","https://openalex.org/W2765570384","https://openalex.org/W4311350540","https://openalex.org/W4381094606"],"abstract_inverted_index":{"Pancreatic":[0,62],"cancer":[1,7,51,89,129,171],"is":[2,24,44,56,130],"the":[3,25,58,83,120,167,176],"fourth":[4],"most":[5],"common":[6],"to":[8,12,20],"cause":[9],"death":[10],"due":[11],"advanced":[13],"stage":[14],"at":[15],"diagnosis":[16],"and":[17,39,87,97,104,107,112,127,173],"poor":[18],"response":[19],"current":[21,80,136],"treatment.":[22],"Autophagy":[23],"lysosome-mediated":[26],"degradation":[27],"pathway":[28,122],"which":[29],"plays":[30,163],"a":[31],"critical":[32],"role":[33],"in":[34,123,158,166],"cellular":[35],"defense,":[36],"quality":[37],"control,":[38],"energy":[40],"metabolism.":[41],"Targeting":[42],"autophagy":[43,54,66,86,126,139,152,162],"now":[45],"an":[46],"exciting":[47],"field":[48],"for":[49],"translational":[50],"research,":[52],"as":[53],"dysfunction":[55],"among":[57],"hallmarks":[59],"of":[60,82,114,119,125,150,169],"cancer.":[61,116,160],"tumors":[63],"have":[64],"elevated":[65],"under":[67],"basal":[68],"conditions":[69],"when":[70],"compared":[71],"with":[72],"other":[73],"epithelial":[74],"cancers.":[75],"This":[76],"review":[77],"describes":[78],"our":[79],"understanding":[81],"interaction":[84],"between":[85],"pancreatic":[88,115,128,159,170],"development,":[90],"including":[91],"risk":[92],"factors":[93],"(e.g.,":[94,102,110,145],"pancreatitis,":[95],"smoking,":[96],"alcohol":[98],"use),":[99],"tumor":[100],"microenvironment":[101],"hypoxia":[103],"stromal":[105],"cells),":[106],"molecular":[108],"biology":[109],"K-Ras":[111],"p53)":[113],"The":[117],"importance":[118],"HMGB1-RAGE":[121],"regulation":[124,168],"also":[131],"presented.":[132],"Finally,":[133],"we":[134],"describe":[135],"studies":[137],"involving":[138],"inhibition":[140],"using":[141],"either":[142],"pharmacological":[143],"inhibitors":[144],"chloroquine)":[146],"or":[147],"RNA":[148],"interference":[149],"essential":[151],"genes":[153],"that":[154],"regulate":[155],"chemotherapy":[156],"sensitivity":[157],"Summarily,":[161],"multiple":[164],"roles":[165],"pathogenesis":[172],"treatment,":[174],"although":[175],"exact":[177],"mechanisms":[178],"remain":[179],"unknown.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
