{"id":"https://openalex.org/W120894281","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.939.4","title":"Dietary glutamine supplementation reduces inflammation and hyperplasia during Helicobacter pylori infection in the mouse stomach","display_name":"Dietary glutamine supplementation reduces inflammation and hyperplasia during Helicobacter pylori infection in the mouse stomach","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W120894281","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.939.4","mag":"120894281"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.939.4","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.939.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.939.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058497219","display_name":"Susan J. Hagen","orcid":"https://orcid.org/0000-0002-2731-3264","observed_orcids":["https://orcid.org/0000-0002-2731-3264"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan J. Hagen","raw_affiliation_strings":["Surgery Beth Israel Deaconess Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Beth Israel Deaconess Medical Center Boston MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027737711","display_name":"Masahiro Ohtani","orcid":"https://orcid.org/0000-0003-2408-5785","observed_orcids":["https://orcid.org/0000-0003-2408-5785"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masahiro Ohtani","raw_affiliation_strings":["Comparative Medicine Massachusetts Institute of Technology Cambridge MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Medicine Massachusetts Institute of Technology Cambridge MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059372016","display_name":"Jin\u2010Rong Zhou","orcid":"https://orcid.org/0000-0002-6745-9495","observed_orcids":["https://orcid.org/0000-0002-6745-9495"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin\u2010Rong Zhou","raw_affiliation_strings":["Surgery Beth Israel Deaconess Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Beth Israel Deaconess Medical Center Boston MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112158610","display_name":"George L. Blackburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George L. Blackburn","raw_affiliation_strings":["Surgery Beth Israel Deaconess Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Beth Israel Deaconess Medical Center Boston MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110088018","display_name":"Nancy S. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy S. Taylor","raw_affiliation_strings":["Comparative Medicine Massachusetts Institute of Technology Cambridge MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Medicine Massachusetts Institute of Technology Cambridge MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676416","display_name":"Barry H. Rickman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry Rickman","raw_affiliation_strings":["Comparative Medicine Massachusetts Institute of Technology Cambridge MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Medicine Massachusetts Institute of Technology Cambridge MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024428264","display_name":"James G. Fox","orcid":"https://orcid.org/0000-0001-9307-6116","observed_orcids":["https://orcid.org/0000-0001-9307-6116"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G. Fox","raw_affiliation_strings":["Comparative Medicine Massachusetts Institute of Technology Cambridge MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Medicine Massachusetts Institute of Technology Cambridge MA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01860635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-glutamine","display_name":"dietary glutamine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gastric-mucosal-injury","display_name":"gastric mucosal injury","score":0.7609999775886536},{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gastric-hyperplasia","display_name":"gastric hyperplasia","score":0.8190000057220459},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.8339999914169312},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.890999972820282},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9620000123977661},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9800000190734863},{"id":"https://openalex.org/keywords/atrophic-gastritis","display_name":"atrophic gastritis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/metaplasia","display_name":"metaplasia","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gastric-colonization","display_name":"gastric colonization","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.7585647702217102},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7382588982582092},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.6616697311401367},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5270559787750244},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5170212984085083},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5088434219360352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49752476811408997},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.49408796429634094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4940831959247589},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.44528502225875854},{"id":"https://openalex.org/C2776497702","wikidata":"https://www.wikidata.org/wiki/Q872095","display_name":"Intestinal metaplasia","level":3,"score":0.42532479763031006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41474050283432007},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39436906576156616},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3339398503303528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32950717210769653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10852593183517456},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.939.4","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.939.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.939.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8535349834","display_name":"GI Mucosal Barrier in Health and Surgical Disease","funder_award_id":"R01DK015681","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2112373003","https://openalex.org/W2263774796","https://openalex.org/W2010526016","https://openalex.org/W2254319275","https://openalex.org/W2293536274","https://openalex.org/W3083401600","https://openalex.org/W1986715541","https://openalex.org/W2342846911","https://openalex.org/W1982689369","https://openalex.org/W2083296521"],"abstract_inverted_index":{"Glutamine":[0],"(GLN)":[1],"protects":[2,21],"cultured":[3],"gastric":[4,22],"mucosal":[5,23],"cells":[6,24],"against":[7,25],"injury.":[8],"The":[9],"purpose":[10],"of":[11,48,82,142],"this":[12,155],"study":[13],"was":[14,117,134,159,186],"to":[15,104],"test":[16,37],"whether":[17],"dietary":[18,202],"GLN":[19,43,93,129,183,203],"supplementation":[20,94],"injury":[26],"in":[27,96,111,146,165,179,191,210],"vivo":[28],".":[29],"METHODS":[30],"C57BL/6":[31],"mice":[32,180],"were":[33,50,61,65,87,176],"fed":[34,181],"a":[35,97,108,135,143,160,188],"purified":[36],"diet":[38,124,184],"without":[39],"or":[40,52,84,162,193],"with":[41,128,139],"5%":[42],"and,":[44],"after":[45],"2":[46],"weeks":[47,74],"pre\u2010feeding,":[49],"sham\u2010":[51],"Helicobacter":[53],"pylori":[54],"(HP\u2010SS1)\u2010infected.":[55],"Body":[56],"weight":[57],"and":[58,63,72,79,149,173,206],"food":[59],"consumption":[60,172],"recorded":[62],"tissues":[64],"analyzed":[66],"for":[67],"pathology":[68],"at":[69,151],"6,":[70],"12,":[71],"20":[73,114,131],"post\u2010infection":[75],"(WPI).":[76],"HP":[77,105,174],"colonization":[78,175],"the":[80,182,211,219],"level":[81],"pro\u2010":[83],"anti\u2010inflammatory":[85,137,166],"cytokines":[86],"determined":[88],"by":[89,107,113,119,130,215],"quantitative":[90],"RT\u2010PCR.":[91],"RESULTS":[92],"resulted":[95],"robust":[98,136],"early":[99],"(6":[100],"WPI)":[101],"inflammatory":[102],"response":[103,138],"followed":[106],"significant":[109,144,189],"reduction":[110,161],"inflammation":[112,205],"WPI.":[115,132,153],"Hyperplasia":[116],"notable":[118],"12":[120],"WPI":[121],"on":[122],"either":[123],"but":[125],"decreased":[126],"significantly":[127],"There":[133],"GLN,":[140],"consisting":[141],"increase":[145],"IL\u20104,":[147],"IL\u201010,":[148],"TGF\u2010\u03b2":[150],"6":[152],"After":[154],"initial":[156],"response,":[157],"there":[158,187],"no":[163],"change":[164,190],"mRNA":[167],"levels":[168],"over":[169],"time.":[170],"Food":[171],"not":[177],"different":[178],"nor":[185],"atrophy":[192],"metaplasia":[194],"scores.":[195],"CONCLUSIONS":[196],"Our":[197],"results":[198],"demonstrate":[199],"that":[200],"supplemental":[201],"reduces":[204],"hyperplasia":[207],"during":[208],"HP\u2010infection":[209],"mouse":[212],"stomach.":[213],"Supported":[214],"R01":[216],"DK15681":[217],"from":[218],"NIH.":[220]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}