{"id":"https://openalex.org/W120892585","doi":null,"title":"[The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study].","display_name":"[The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study].","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W120892585","mag":"120892585","pmid":"https://pubmed.ncbi.nlm.nih.gov/7936334"},"language":"it","primary_location":{"id":"pmid:7936334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7936334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva cardioangiologica","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109031693","display_name":"M R Cesarone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M R Cesarone","raw_affiliation_strings":["Istituto di Clinica Cardiovascolare, Universit\u00e0 degli Studi G. D'Annunzio, Chieti"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Clinica Cardiovascolare, Universit\u00e0 degli Studi G. D'Annunzio, Chieti","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060170894","display_name":"GIUSEPPE LAURORA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Laurora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039271240","display_name":"M T De Sanctis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T De Sanctis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000733414","display_name":"LUCREZIA INCANDELA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Incandela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001928080","display_name":"Roberto Grimaldi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Grimaldi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Marelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Marelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013025165","display_name":"Giovanni Vincent Belcaro","orcid":"https://orcid.org/0000-0002-5811-6677","observed_orcids":["https://orcid.org/0000-0002-5811-6677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Belcaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.01605373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"6","first_page":"299","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centella-asiatica","display_name":"Centella asiatica","score":1.0},{"id":"https://openalex.org/keywords/venous-insufficiency","display_name":"venous insufficiency","score":0.9319999814033508},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/skin-blood-flow","display_name":"skin blood flow","score":0.7049999833106995},{"id":"https://openalex.org/keywords/transcutaneous-oxygen-pressure","display_name":"transcutaneous oxygen tension","score":0.8600000143051147},{"id":"https://openalex.org/keywords/transcutaneous-carbon-dioxide-tension","display_name":"transcutaneous carbon dioxide tension","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6079999804496765},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9658985137939453},{"id":"https://openalex.org/C2779077069","wikidata":"https://www.wikidata.org/wiki/Q1348880","display_name":"Centella","level":2,"score":0.8498353958129883},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7416189908981323},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.6426513195037842},{"id":"https://openalex.org/C2776106345","wikidata":"https://www.wikidata.org/wiki/Q1088042","display_name":"Chronic venous insufficiency","level":2,"score":0.627623438835144},{"id":"https://openalex.org/C2776513394","wikidata":"https://www.wikidata.org/wiki/Q1412400","display_name":"Microangiopathy","level":3,"score":0.6047534346580505},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.5080337524414062},{"id":"https://openalex.org/C2777140959","wikidata":"https://www.wikidata.org/wiki/Q10343041","display_name":"pCO2","level":2,"score":0.42381781339645386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3889933228492737},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37007156014442444},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.342905193567276},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.19648540019989014},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09271061420440674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08633166551589966},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.060529619455337524},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011186","descriptor_name":"Postphlebitic Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011186","descriptor_name":"Postphlebitic Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014689","descriptor_name":"Venous Insufficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014689","descriptor_name":"Venous Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7936334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7936334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva cardioangiologica","raw_type":"Clinical Trial"},{"id":"mag:120892585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7936334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W189364947","https://openalex.org/W2810688187","https://openalex.org/W63373986","https://openalex.org/W2462389059","https://openalex.org/W173288084","https://openalex.org/W134442714","https://openalex.org/W85860680","https://openalex.org/W2091900972","https://openalex.org/W97987599","https://openalex.org/W2004298891"],"abstract_inverted_index":{"In":[0],"87":[1],"patients":[2],"with":[3,79],"chronic":[4],"venous":[5,92],"hypertensive":[6,93],"microangiopathy":[7],"the":[8,68,87,96],"efficacy":[9,88],"of":[10,24,89,98],"oral":[11],"FTTCA":[12,90,99],"(Centella":[13],"asiatica)":[14],"administered":[15],"for":[16],"60":[17,31],"days":[18],"was":[19,36,45],"tested.":[20],"The":[21,43],"microcirculatory":[22],"effects":[23,51,97],"two":[25],"dosages":[26],"(30":[27],"mg":[28,32],"bid":[29],"and":[30,48,61,64,74],"bid)":[33],"versus":[34],"placebo":[35],"assessed":[37],"in":[38,77,91],"a":[39],"double":[40],"blind":[41],"study.":[42],"compound":[44],"well":[46],"tolerated":[47],"no":[49],"unwanted":[50],"were":[52],"observed.":[53],"Microcirculatory":[54],"parameters--peri-malleolar":[55],"skin":[56],"flux":[57],"at":[58,82],"rest":[59],"(RF)":[60],"transcutaneous":[62],"PO2":[63,75],"PCO2--improved":[65],"as":[66],"did":[67],"abnormally":[69],"increased":[70,76],"RF,":[71],"PCO2":[72],"decreased":[73],"comparison":[78],"values":[80],"measured":[81],"inclusion.":[83],"These":[84],"results":[85],"confirm":[86],"microangiopathy.":[94],"Furthermore":[95],"appear":[100],"to":[101],"be":[102],"dose-related.":[103]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
