{"id":"https://openalex.org/W120845308","doi":null,"title":"Ionic changes and alterations in the size of the extracellular space during epileptic activity.","display_name":"Ionic changes and alterations in the size of the extracellular space during epileptic activity.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W120845308","mag":"120845308","pmid":"https://pubmed.ncbi.nlm.nih.gov/3518349"},"language":"en","primary_location":{"id":"pmid:3518349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3518349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in neurology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088729187","display_name":"H. D. Lux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H D Lux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055448298","display_name":"Uwe Heinemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Heinemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021076423","display_name":"Irmgard D. Dietzel","orcid":"https://orcid.org/0000-0003-4009-6249","observed_orcids":["https://orcid.org/0000-0003-4009-6249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Dietzel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6935,"has_fulltext":false,"cited_by_count":290,"citation_normalized_percentile":{"value":0.91088984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"44","issue":null,"first_page":"619","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.4027999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.4027999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.23340000212192535,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.20759999752044678,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-space","display_name":"extracellular space","score":0.8349999785423279},{"id":"https://openalex.org/keywords/epileptiform-activity","display_name":"epileptiform activity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/potassium-accumulation","display_name":"potassium accumulation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/extracellular-osmolarity","display_name":"extracellular osmolarity","score":0.800000011920929},{"id":"https://openalex.org/keywords/water-flux","display_name":"water flux","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hippocampal-slices","display_name":"hippocampal slices","score":0.925000011920929},{"id":"https://openalex.org/keywords/synaptic-depression","display_name":"synaptic depression","score":0.4099999964237213},{"id":"https://openalex.org/keywords/ion-selective-microelectrodes","display_name":"ion-selective microelectrodes","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.8842513561248779},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.7952544689178467},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.7706466913223267},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5927623510360718},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.52898108959198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46229690313339233},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.446731835603714},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.43196603655815125},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.4114784896373749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35239243507385254},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32248643040657043},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.28063851594924927},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.23490610718727112},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12012213468551636}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3518349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3518349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in neurology","raw_type":"Journal Article"},{"id":"mag:120845308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3518349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W179647900","https://openalex.org/W2005813690","https://openalex.org/W2056251473","https://openalex.org/W89662392","https://openalex.org/W2154734905","https://openalex.org/W3011621535","https://openalex.org/W2068146904","https://openalex.org/W2015575130","https://openalex.org/W2249441611","https://openalex.org/W71579238"],"abstract_inverted_index":{"Experiments":[0],"with":[1,101,385],"ion-selective":[2],"microelectrodes":[3],"revealed":[4],"that":[5,130,143],"a":[6,62,128,205,214,224,296],"considerable":[7],"activity":[8,22,321,374],"of":[9,64,68,138,147,186,207,226,231,248,261,267,280,288,338,341,344,362,367,401],"K":[10,46,51,88,105,109,132,140,145,156,187,196,233,245],"ions":[11,197],"appears":[12],"temporarily":[13],"in":[14,119,164,283,314,331,375,382],"the":[15,27,43,57,65,76,86,94,104,113,116,123,165,174,184,218,221,227,238,259,268,276,281,284,292,329,339,342,348,352,396],"extracellular":[16,59,87,117,208,293,349],"space":[17,294,350],"(ES)":[18],"during":[19,372],"enhanced":[20,319],"neuronal":[21,263,290],"and":[23,33,48,142,172,179,195,250,322,333,351,359,391,399],"is":[24,157,167,241,270],"removed":[25],"from":[26,42,112,217,258,347],"ES":[28,166,219,228,269],"by":[29,61,170,202,298,307],"diffusion,":[30],"active":[31],"uptake,":[32],"entry":[34],"into":[35,115,133,220],"glial":[36,39,45,50,77,81,134,148,354],"cells.":[37,82],"The":[38,53,160,193,302,389],"uptake":[40,325],"results":[41],"preferential":[44],"permeability":[47],"spatial":[49],"buffering.":[52],"glia":[54,249],"responds":[55],"to":[56,103,121,183,213,244,253,318,328],"local":[58],"accumulation":[60,141,188],"depolarization":[63,72],"exposed":[66],"part":[67],"its":[69],"membrane.":[70],"This":[71,126,272],"will":[73,97,110],"spread":[74],"along":[75],"syncytium":[78],"or":[79],"extended":[80],"At":[83,235,286],"sites":[84,137,230,287],"where":[85],"concentration":[89],"has":[90],"not":[91],"yet":[92],"increased,":[93],"membrane":[95],"potential":[96,310],"thus":[98],"be":[99],"depolarized":[100],"respect":[102],"diffusion":[106],"potential.":[107],"Here":[108],"move":[111],"intra-":[114],"space,":[118],"order":[120],"restore":[122],"electrochemical":[124],"equilibrium.":[125],"induces":[127],"current":[129,162],"carries":[131],"cells":[135,149],"at":[136,150,229],"maximal":[139,232,262,289],"transports":[144],"out":[146,247],"remote":[151,236,257],"areas.":[152],"In":[153],"this":[154,368],"way":[155],"spatially":[158],"redistributed.":[159],"corresponding":[161],"loop":[163],"predominantly":[168],"carried":[169],"Na":[171,178],"Cl,":[173],"majority":[175],"ions.":[176],"Thus,":[177,256],"Ca":[180],"are":[181,198,305],"transported":[182],"site":[185],"while":[189],"Cl":[190,194,251],"moves":[191],"away.":[192],"only":[199],"partially":[200],"replaced":[201],"Na.":[203],"Hence,":[204],"decrease":[206],"osmolarity":[209,316],"results,":[210],"which":[211],"leads":[212],"water":[215],"flux":[216],"cells,":[222],"inducing":[223],"shrinkage":[225],"accumulation.":[234],"sites,":[237],"opposite":[239],"effect":[240],"expected":[242],"due":[243,317],"flow":[246],"transport":[252],"these":[254,363],"sites.":[255],"area":[260],"activity,":[264,291],"an":[265],"increase":[266,313],"expected.":[271],"mechanism":[273],"can":[274],"explain":[275],"measured":[277],"depth":[278],"profile":[279],"changes":[282,304,330,394],"ES.":[285],"undergoes":[295],"reduction":[297],"more":[299],"than":[300],"30%.":[301],"ionic":[303,334,393],"accompanied":[306],"slow":[308],"negative":[309],"shifts.":[311],"An":[312],"intracellular":[315,392],"metabolic":[320],"possibly":[323],"KCl":[324],"mechanisms":[326],"contributes":[327],"volume":[332],"concentration.":[335],"Model":[336],"calculations":[337],"after-effects":[340],"loss":[343],"positive":[345],"charges":[346],"K-specific":[353],"buffering":[355],"could":[356],"predict":[357],"size":[358],"time":[360],"course":[361],"changes.":[364],"Experimental":[365],"tests":[366],"view":[369],"include":[370],"observations":[371],"epileptiform":[373],"gliotic":[376],"scar":[377],"foci":[378],"as":[379,381],"well":[380],"hippocampal":[383],"slices":[384],"depressed":[386],"synaptic":[387],"transmission.":[388],"extra-":[390],"influence":[395],"generation,":[397],"spread,":[398],"termination":[400],"seizure":[402],"activity.(ABSTRACT":[403],"TRUNCATED":[404],"AT":[405],"400":[406],"WORDS)":[407]},"counts_by_year":[{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
