{"id":"https://openalex.org/W1205458192","doi":"https://doi.org/10.1042/bj0600604","title":"Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue","display_name":"Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue","publication_year":1955,"publication_date":"1955-08-01","ids":{"openalex":"https://openalex.org/W1205458192","doi":"https://doi.org/10.1042/bj0600604","mag":"1205458192","pmid":"https://pubmed.ncbi.nlm.nih.gov/13249955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1216159"},"language":"en","primary_location":{"id":"doi:10.1042/bj0600604","doi":"https://doi.org/10.1042/bj0600604","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj0600604","pdf_url":"https://portlandpress.com/biochemj/article-pdf/60/4/604/803932/bj0600604.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/60/4/604/803932/bj0600604.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111551991","display_name":"C. De Duve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C. de Duve","raw_affiliation_strings":["Department of Physiological Chemistry, University of Louvain, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, University of Louvain, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109943828","display_name":"Berton C. Pressman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"B. C. Pressman","raw_affiliation_strings":["Department of Physiological Chemistry, University of Louvain, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, University of Louvain, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039611143","display_name":"R. Gianetto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R. Gianetto","raw_affiliation_strings":["Department of Physiological Chemistry, University of Louvain, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, University of Louvain, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020611336","display_name":"Robert Wattiaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R. Wattiaux","raw_affiliation_strings":["Department of Physiological Chemistry, University of Louvain, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, University of Louvain, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057748682","display_name":"Fran\u00e7oise Appelmans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"F. Appelmans","raw_affiliation_strings":["Department of Physiological Chemistry, University of Louvain, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, University of Louvain, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":28.3776,"has_fulltext":true,"cited_by_count":4222,"citation_normalized_percentile":{"value":0.9997855,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"60","issue":"4","first_page":"604","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.7229999899864197},{"id":"https://openalex.org/keywords/acid-phosphatase","display_name":"acid phosphatase","score":0.878000020980835},{"id":"https://openalex.org/keywords/cytoplasmic-granules","display_name":"cytoplasmic granules","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.699999988079071},{"id":"https://openalex.org/keywords/microsomes","display_name":"microsomes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enzyme-fractionation","display_name":"enzyme fractionation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/subcellular-fractionation","display_name":"subcellular fractionation","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.6706303954124451},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.660197377204895},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5035619139671326},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.4948241114616394},{"id":"https://openalex.org/C2780154274","wikidata":"https://www.wikidata.org/wiki/Q7126717","display_name":"Download","level":2,"score":0.45823365449905396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44269227981567383},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43164899945259094},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.42754611372947693},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4195636510848999},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2653975486755371},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj0600604","doi":"https://doi.org/10.1042/bj0600604","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj0600604","pdf_url":"https://portlandpress.com/biochemj/article-pdf/60/4/604/803932/bj0600604.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:13249955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13249955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1216159","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1216159/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bj0600604","doi":"https://doi.org/10.1042/bj0600604","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj0600604","pdf_url":"https://portlandpress.com/biochemj/article-pdf/60/4/604/803932/bj0600604.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1205458192.pdf","grobid_xml":"https://content.openalex.org/works/W1205458192.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W28733762","https://openalex.org/W30038258","https://openalex.org/W36660951","https://openalex.org/W49177676","https://openalex.org/W55081711","https://openalex.org/W81215257","https://openalex.org/W90835690","https://openalex.org/W115371352","https://openalex.org/W119973049","https://openalex.org/W143520015","https://openalex.org/W170240114","https://openalex.org/W172811586","https://openalex.org/W179178416","https://openalex.org/W186631721","https://openalex.org/W205272131","https://openalex.org/W338143367","https://openalex.org/W1554289400","https://openalex.org/W1582080277","https://openalex.org/W1761552064","https://openalex.org/W1837133346","https://openalex.org/W1993246239","https://openalex.org/W2018243491","https://openalex.org/W2041116507","https://openalex.org/W2047340979","https://openalex.org/W2074982776","https://openalex.org/W2093436596","https://openalex.org/W2230075007","https://openalex.org/W2318710512","https://openalex.org/W2398878853","https://openalex.org/W2401359075","https://openalex.org/W2401749687","https://openalex.org/W2410521897","https://openalex.org/W2410809094","https://openalex.org/W2413461304","https://openalex.org/W2414874132","https://openalex.org/W2415205045","https://openalex.org/W2427992362","https://openalex.org/W2438954934","https://openalex.org/W2465443135"],"related_works":["https://openalex.org/W170240114","https://openalex.org/W1993246239","https://openalex.org/W152126171","https://openalex.org/W2040698567","https://openalex.org/W2565833280","https://openalex.org/W1995616301","https://openalex.org/W2045756262","https://openalex.org/W2418312850","https://openalex.org/W1797546626","https://openalex.org/W1983277003"],"abstract_inverted_index":{"The":[0],"finding":[1],"that":[2],"the":[3,32,60,64,67],"acid":[4,74],"phosphatase":[5,75],"of":[6,15,25,34,38,66],"rat":[7],"liver":[8],"is":[9],"enclosed":[10],"within":[11],"a":[12,35],"special":[13],"type":[14],"cytoplasmic":[16],"granules,":[17],"with":[18],"sedimentation":[19],"properties":[20],"inter-":[21],"mediate":[22],"between":[23,80],"those":[24],"mitochondria":[26,81],"and":[27,82],"microsomes,":[28],"has":[29,56],"led":[30],"to":[31,43,63,72],"development":[33],"new":[36],"scheme":[37,55],"fractionation,":[39],"whereby":[40],"enzymes":[41],"attached":[42],"these":[44],"granules":[45],"can":[46],"be":[47],"readily":[48],"identified":[49],"(Appelmans,":[50],"Wattiaux":[51],"&":[52,92],"Duve,":[53],"1955).This":[54],"been":[57],"applied":[58],"in":[59,76],"present":[61],"work":[62],"study":[65],"following":[68],"enzymes,":[69],"previously":[70],"shown":[71],"resemble":[73],"being":[77],"unequally":[78],"distributed":[79],"microsomes:":[83],"DPNH-":[84],"cytochrome":[85],"c":[86],"reductase":[87],"(Hogeboom,":[88],"1949;":[89],"Hoge-":[90],"boom":[91],"Schneider,":[93],"1950a;":[94]},"counts_by_year":[{"year":2026,"cited_by_count":38},{"year":2025,"cited_by_count":46},{"year":2024,"cited_by_count":46},{"year":2023,"cited_by_count":48},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":48},{"year":2020,"cited_by_count":57},{"year":2019,"cited_by_count":47},{"year":2018,"cited_by_count":44},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":50},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}