{"id":"https://openalex.org/W12049018","doi":"https://doi.org/10.1007/978-1-59259-725-3_14","title":"Receptor- and Carrier-Mediated Transport Systems for Folates and Antifolates","display_name":"Receptor- and Carrier-Mediated Transport Systems for Folates and Antifolates","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W12049018","doi":"https://doi.org/10.1007/978-1-59259-725-3_14","mag":"12049018"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-725-3_14","doi":"https://doi.org/10.1007/978-1-59259-725-3_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-725-3_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antifolate Drugs in Cancer Therapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2476057351","display_name":"Antifolate Drugs in Cancer Therapy"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007946879","display_name":"Gerrit Jansen","orcid":"https://orcid.org/0000-0001-8190-8368","observed_orcids":["https://orcid.org/0000-0001-8190-8368","https://orcid.org/0000-0002-3636-8136"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"G. Jansen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007946879"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.965,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.99577167,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"293","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.09359999746084213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-transport","display_name":"folate transport","score":0.9629999995231628},{"id":"https://openalex.org/keywords/reduced-folate-carrier","display_name":"reduced folate carrier","score":0.8790000081062317},{"id":"https://openalex.org/keywords/antifolate-drugs","display_name":"antifolate","score":0.8069999814033508},{"id":"https://openalex.org/keywords/folate-homeostasis","display_name":"folate homeostasis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dihydrofolate-reductase-inhibitors","display_name":"dihydrofolate reductase inhibitors","score":0.8560000061988831},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8859999775886536},{"id":"https://openalex.org/keywords/aminopterin","display_name":"aminopterin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/thymidylate-synthase-inhibitors","display_name":"thymidylate synthase inhibitors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glycinamide-ribonucleotide-transformylase","display_name":"GART","score":0.8709999918937683},{"id":"https://openalex.org/keywords/folate-analogs","display_name":"folate analogs","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.640999972820282},{"id":"https://openalex.org/keywords/folate-metabolism","display_name":"folate metabolism","score":0.47099998593330383},{"id":"https://openalex.org/keywords/membrane-transport","display_name":"membrane transport","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.8512827754020691},{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.744512140750885},{"id":"https://openalex.org/C2781382166","wikidata":"https://www.wikidata.org/wiki/Q50573407","display_name":"Antifolate","level":4,"score":0.7040563821792603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6902655363082886},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.6123495101928711},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5479814410209656},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.5443392395973206},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.47246766090393066},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46054428815841675},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.4465067386627197},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.42502111196517944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37888383865356445},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36231982707977295},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.2107052505016327},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.14563021063804626},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1071418821811676},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/978-1-59259-725-3_14","doi":"https://doi.org/10.1007/978-1-59259-725-3_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-725-3_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antifolate Drugs in Cancer Therapy","raw_type":"book-chapter"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/a9aa61e7-f22f-4385-8c05-d930e2eff34e","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/a9aa61e7-f22f-4385-8c05-d930e2eff34e","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jansen, G 1999, Receptor- and carrier-mediated transport systems for folates and antifolates: exploitation for folate-based chemotherapy and immunotherapy. in In: \"Antifolate Drugs in Cancer Therapy\". Humana Press, pp. 293-321.","raw_type":"info:eu-repo/semantics/bookPart"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/3e04181c-26f9-4a08-9dda-e5b624584147","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/3e04181c-26f9-4a08-9dda-e5b624584147","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: \"Antifolate Drugs in Cancer Therapy\", 293 - 321","raw_type":"info:eu-repo/semantics/bookpart"},{"id":"mag:2914594756","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/receptor-and-carrier-mediated-transport-systems-for-folates-and-a","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":194,"referenced_works":["https://openalex.org/W66784854","https://openalex.org/W93095092","https://openalex.org/W99620023","https://openalex.org/W116308216","https://openalex.org/W176263485","https://openalex.org/W1421271778","https://openalex.org/W1479070774","https://openalex.org/W1484903029","https://openalex.org/W1488798457","https://openalex.org/W1489298252","https://openalex.org/W1493877135","https://openalex.org/W1502486752","https://openalex.org/W1504640316","https://openalex.org/W1507953239","https://openalex.org/W1515543767","https://openalex.org/W1517703555","https://openalex.org/W1524027952","https://openalex.org/W1526548918","https://openalex.org/W1527500190","https://openalex.org/W1529220262","https://openalex.org/W1531912755","https://openalex.org/W1538643202","https://openalex.org/W1540787354","https://openalex.org/W1551928250","https://openalex.org/W1555616833","https://openalex.org/W1556386625","https://openalex.org/W1557687412","https://openalex.org/W1560482245","https://openalex.org/W1561405046","https://openalex.org/W1562169645","https://openalex.org/W1563562415","https://openalex.org/W1564575603","https://openalex.org/W1565425041","https://openalex.org/W1570947004","https://openalex.org/W1573184761","https://openalex.org/W1573389093","https://openalex.org/W1580222663","https://openalex.org/W1581503432","https://openalex.org/W1581552787","https://openalex.org/W1583876657","https://openalex.org/W1589005530","https://openalex.org/W1590534911","https://openalex.org/W1591370090","https://openalex.org/W1591958125","https://openalex.org/W1592913469","https://openalex.org/W1595469935","https://openalex.org/W1631338702","https://openalex.org/W1647609745","https://openalex.org/W1666409248","https://openalex.org/W1766501050","https://openalex.org/W1804726264","https://openalex.org/W1852614201","https://openalex.org/W1880102547","https://openalex.org/W1888458155","https://openalex.org/W1909111805","https://openalex.org/W1964922251","https://openalex.org/W1965201843","https://openalex.org/W1968866598","https://openalex.org/W1969552935","https://openalex.org/W1971341208","https://openalex.org/W1971804824","https://openalex.org/W1976406151","https://openalex.org/W1976665585","https://openalex.org/W1977621288","https://openalex.org/W1977715167","https://openalex.org/W1978667402","https://openalex.org/W1979745458","https://openalex.org/W1980773456","https://openalex.org/W1982513234","https://openalex.org/W1983416032","https://openalex.org/W1983686963","https://openalex.org/W1984462338","https://openalex.org/W1984948155","https://openalex.org/W1986177211","https://openalex.org/W1987905087","https://openalex.org/W1988443167","https://openalex.org/W1989041902","https://openalex.org/W1990493121","https://openalex.org/W1992593557","https://openalex.org/W1993354505","https://openalex.org/W1993803695","https://openalex.org/W1993899589","https://openalex.org/W1995376945","https://openalex.org/W2001731555","https://openalex.org/W2002344615","https://openalex.org/W2002710745","https://openalex.org/W2003435018","https://openalex.org/W2004742967","https://openalex.org/W2005038274","https://openalex.org/W2005930815","https://openalex.org/W2006004944","https://openalex.org/W2006213902","https://openalex.org/W2010483755","https://openalex.org/W2012635718","https://openalex.org/W2018033770","https://openalex.org/W2020103848","https://openalex.org/W2020475423","https://openalex.org/W2020609674","https://openalex.org/W2020980897","https://openalex.org/W2021764224","https://openalex.org/W2024386750","https://openalex.org/W2027126829","https://openalex.org/W2028776386","https://openalex.org/W2031825904","https://openalex.org/W2035508242","https://openalex.org/W2038773406","https://openalex.org/W2038931392","https://openalex.org/W2039934078","https://openalex.org/W2041797676","https://openalex.org/W2042493999","https://openalex.org/W2042693747","https://openalex.org/W2043804660","https://openalex.org/W2046053482","https://openalex.org/W2046075094","https://openalex.org/W2047546545","https://openalex.org/W2051052717","https://openalex.org/W2053607241","https://openalex.org/W2054073458","https://openalex.org/W2059759975","https://openalex.org/W2060726255","https://openalex.org/W2062515711","https://openalex.org/W2063431146","https://openalex.org/W2064525881","https://openalex.org/W2064754325","https://openalex.org/W2065337815","https://openalex.org/W2067372171","https://openalex.org/W2067720409","https://openalex.org/W2067915381","https://openalex.org/W2069418933","https://openalex.org/W2069444054","https://openalex.org/W2070833447","https://openalex.org/W2074292579","https://openalex.org/W2075437346","https://openalex.org/W2077345539","https://openalex.org/W2078862165","https://openalex.org/W2081091078","https://openalex.org/W2081189233","https://openalex.org/W2081522503","https://openalex.org/W2084248231","https://openalex.org/W2084357980","https://openalex.org/W2086863971","https://openalex.org/W2090121427","https://openalex.org/W2094448820","https://openalex.org/W2097637786","https://openalex.org/W2101515095","https://openalex.org/W2105678378","https://openalex.org/W2106060121","https://openalex.org/W2106482770","https://openalex.org/W2106636322","https://openalex.org/W2106907372","https://openalex.org/W2109550151","https://openalex.org/W2109927269","https://openalex.org/W2110083695","https://openalex.org/W2125682747","https://openalex.org/W2127846911","https://openalex.org/W2131020219","https://openalex.org/W2131232623","https://openalex.org/W2133499001","https://openalex.org/W2133786616","https://openalex.org/W2133806000","https://openalex.org/W2138465718","https://openalex.org/W2139609510","https://openalex.org/W2140720774","https://openalex.org/W2142904352","https://openalex.org/W2144075705","https://openalex.org/W2147271502","https://openalex.org/W2150920867","https://openalex.org/W2154744970","https://openalex.org/W2155834747","https://openalex.org/W2156590312","https://openalex.org/W2160036851","https://openalex.org/W2162125295","https://openalex.org/W2165873235","https://openalex.org/W2176671673","https://openalex.org/W2202479314","https://openalex.org/W2218713096","https://openalex.org/W2258754807","https://openalex.org/W2263001887","https://openalex.org/W2274909698","https://openalex.org/W2400544314","https://openalex.org/W2410737143","https://openalex.org/W2413966932","https://openalex.org/W2415005383","https://openalex.org/W2415189599","https://openalex.org/W2437172426","https://openalex.org/W2478165818","https://openalex.org/W2914760410","https://openalex.org/W2917426357","https://openalex.org/W2919743063","https://openalex.org/W2920568806","https://openalex.org/W2921932564","https://openalex.org/W2924635474","https://openalex.org/W4239756883","https://openalex.org/W4253056702"],"related_works":["https://openalex.org/W1518711324","https://openalex.org/W1984582891","https://openalex.org/W2101259585","https://openalex.org/W2084201616","https://openalex.org/W280310767","https://openalex.org/W2067882963","https://openalex.org/W1992886767","https://openalex.org/W44803896","https://openalex.org/W2914594756","https://openalex.org/W2319663603"],"abstract_inverted_index":{"Eukaryotic":[0],"cells":[1,95],"lack":[2],"the":[3,20,36,49,57,75,185,193,208,221,225,232,244],"possibility":[4],"of":[5,9,22,38,56,61,90,129,168,180,210,220,227,234,267,274,305],"de":[6],"novo":[7],"biosynthesis":[8,21],"reduced":[10,39,62,245],"folate":[11,32,40,63,91,112,125,136,147,182,212,229,246,253],"cofactors":[12,41,64],"that":[13,71,140,188,215],"are":[14,216],"required":[15],"as":[16,103,115,260],"one-carbon":[17],"donors":[18],"in":[19,93,146,197],"thymidylate,":[23],"purines,":[24],"and":[25,53,118,161,231,250,271],"amino":[26],"acids":[27],"(1).For":[28],"this":[29],"reason,":[30],"cellular":[31,86],"homeostasis":[33,230],"depends":[34],"on":[35,207],"delivery":[37,233],"from":[42,224],"extracellular":[43],"fluids.":[44],"At":[45],"a":[46,100,104,251,286],"physiological":[47],"pH,":[48],"negatively":[50],"charged":[51],"\u03b1-":[52],"\u03b3-carboxyl":[54],"groups":[55],"glutamate":[58],"side":[59],"chain":[60],"change":[65],"these":[66,169,181,275,290],"molecules":[67],"into":[68,238,300],"divalent":[69],"anions":[70],"cannot":[72],"simply":[73],"pass":[74],"plasma":[76],"membrane":[77,190],"but":[78],"require":[79],"(a)":[80],"specific":[81],"transport":[82,191,213],"system(s)":[83],"for":[84,99,107],"their":[85,199],"entry.":[87],"The":[88,178],"importance":[89],"metabolism":[92,126],"tumor":[94,239],"has":[96],"been":[97],"recognized":[98,122],"long":[101],"time":[102],"potential":[105,174],"target":[106,142],"chemotherapy":[108],"(2\u20136).":[109],"Historically,":[110],"classical":[111],"analogs":[113,137,183],"such":[114],"aminopterin":[116],"(AMT)":[117],"methotrexate":[119],"(MTX)":[120],"were":[121,138],"to":[123,218,259],"disrupt":[124],"through":[127],"inhibition":[128],"dihydrofolate":[130],"reductase":[131],"(DHFR)":[132],"(7).":[133],"More":[134],"recently,":[135],"synthesized":[139],"could":[141],"other":[143],"key":[144],"enzymes":[145],"metabolism,":[148],"including":[149],"thymidylate":[150],"synthase":[151],"(TS)":[152],"(8,":[153],"9)":[154],"glycinamide":[155],"ribonucleotide":[156],"transformylase":[157],"(GARTFase)":[158],"(10,":[159],"11)":[160],"folylpolyglutamate":[162],"synthetase":[163],"(FPGS)":[164],"(12).":[165],"A":[166,265],"number":[167],"novel":[170],"antifolates":[171],"have":[172],"demonstrated":[173],"clinical":[175],"activity":[176,304],"(3,13\u201318).":[177],"majority":[179],"share":[184],"common":[186],"feature":[187],"efficient":[189],"is":[192],"first":[194],"determining":[195],"factor":[196],"exerting":[198],"biological":[200],"activity.":[201],"This":[202],"chapter":[203],"will":[204,277],"mainly":[205],"focus":[206],"role":[209],"two":[211],"systems":[214],"considered":[217],"be":[219,278,298],"greatest":[222],"relevance":[223],"perspective":[226],"mediating":[228],"folate-based":[235],"chemotherapeutic":[236],"drugs":[237,307],"cells.":[240],"These":[241],"transporters":[242,276],"include":[243],"carrier":[247],"(RFC)":[248],"(19\u201322)":[249],"membrane-associated":[252,261],"receptor":[254],"(MFR)":[255],"(22\u201325)":[256],"also":[257],"referred":[258],"folate-binding":[262],"protein":[263],"(mFBP).":[264],"summary":[266],"some":[268],"molecular,":[269],"biochemical,":[270],"functional":[272],"properties":[273,291],"given":[279],"(see":[280,292,308],"e.g.,":[281],"Table":[282,309],"1)":[283],"along":[284],"with":[285],"few":[287],"examples":[288],"how":[289],"Fig.":[293],"2A,":[294],"B,":[295],"below)":[296],"may":[297],"translated":[299],"an":[301],"improved":[302],"biological/cytotoxic":[303],"antifolate":[306],"2).":[310]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}